Abstract: Described herein are methods and systems for identifying and/or treating subjects having cancer who are more likely to respond to treatment with an inhibitor of the transcription factor HIF-2?.

Abstract: Described herein are methods and systems for identifying and/or treating subjects having cancer who are more likely to respond to treatment with an inhibitor of the transcription factor HIF-2?.

Abstract: The present disclosure relates to an OLED device and a manufacturing method thereof, and a display panel. The OLED device includes: a substrate; an anode layer and a pixel-defining layer, provided on a side of the substrate, the pixel-defining layer including a plurality of pixel-defining structures, and adjacent pixel-defining structures defining a pixel unit; a first organic layer, covering the anode layer and the pixel-defining layer; a light-emitting layer, provided on a side of the first organic layer away from the substrate and within the pixel unit; and a cathode layer, covering the light-emitting layer and the first organic layer. The first organic layer includes at least one open groove.

Abstract: A dual pre-stacking system of steel plates for a single cutting line and a stacking method therefor. The dual pre-stacking system comprises: a cooling bed inspection stand, a crop shear with a cut-to-length function, a bilateral shear, 1#inkjet printer, a front pre-stacker, a cut-to-length shear, a length and thickness gauge, 2#inkjet printer, surface check/size inspection and fitting, and a rear pre-stacker arranged in order along the roller. The dual pre-stacking system and the stacking method therefor of the present invention solves the problem that the inkjet printing, size fitting and pre-stacking in the later zone of the cutting line are slow when producing steel plates with high magnification, simultaneously performs pre-stacking operation after bilateral cutting and surface check in one cutting line, achieves synchronous inkjet printing/imprinting, size fitting and pre-stacking of the steel plates at two sites along the cutting line.

Abstract: A method for forging a niobium-tungsten alloy forged ring, including: (S1) subjecting an alloy ingot to turning, chamfering, spraying with an anti-oxidation coating, stainless-steel sheathing, heating and upsetting to obtain a primary pancake with a flat-die hammer, rapid-forging press or hydraulic press; (S2) subjecting an inner pole to wire electrical discharge machining to obtain a ring blank followed by machining to remove the stainless-steel sheath and oxide scale and defects; and subjecting the ring blank to fluorescent/dye penetrant inspection followed by vacuum stress-relief annealing; (S3) subjecting the ring blank to core shaft/saddle forging on the flat-die hammer or rapid-forging press to obtain a crude forged ring; and (S4) subjecting the crude forged ring to vacuum recrystallization annealing to obtain a desired forged ring.

Abstract: The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy-induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.

Abstract: Provided herein is a 7-genes signature, an algorithm to evaluate a patient's risk score, and methods of use thereof. The methods provided herein include methods of use of a risk score to predict lung cancer patient survival and lung cancer patient likelihood to respond to adjuvant chemotherapy.

Abstract: The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy-induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.

Abstract: The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy-induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.

Abstract: Implementations discussed and claimed herein provide systems and methods for characterizing patient tissue of a patient. In one implementation, a pathological image of the patient tissue is received. Nuclei of the plurality of cells in the pathological image are simultaneously segmented and classified using a histology-based digital staining system. The nuclei of the plurality of cells are segmented according to spatial location and classified according to cell type, thereby generating one or more groups of nuclei. Each of the one or more groups of nuclei have an identified cell type. A composition and a spatial organization of a tumor microenvironment of the patient tissue is determined based on the one or more groups of nuclei. A prognostic model for the patient is generated based on the composition and the spatial organization of the tumor microenvironment.

Abstract: The present application provides a display panel, a manufacturing method, a detection method, and a display device. The display panel includes a display area and a non-display area surrounding the display area. The non-display area includes: a crack detection line surrounding the display area; a screen control line; a plurality of switch signal lines; and a plurality of detection switches electrically connected at different positions to the crack detection line. Each detection switch is also connected to the screen control line and a respective switch signal line, and allows conduction between the crack detection line and the screen control line based on the switch signal input by the switch signal line, such that the screen control line drives the display panel to display according to the test signal input by the crack detection line.

Abstract: A dual pre-stacking system of steel plates for a single cutting line and a stacking method therefor. The dual pre-stacking system comprises: a cooling bed inspection stand, a crop shear with a cut-to-length function, a bilateral shear, 1# inkjet printer, a front pre-stacker, a cut-to-length shear, a length and thickness gauge, 2# inkjet printer, surface check/size inspection and fitting, and a rear pre-stacker arranged in order along the roller.

Abstract: A method for forging a niobium-tungsten alloy forged ring, including: (S1) subjecting an alloy ingot to turning, chamfering, spraying with an anti-oxidation coating, stainless-steel sheathing, heating and upsetting to obtain a primary pancake with a flat-die hammer, rapid-forging press or hydraulic press; (S2) subjecting an inner pole to wire electrical discharge machining to obtain a ring blank followed by machining to remove the stainless-steel sheath and oxide scale and defects; and subjecting the ring blank to fluorescent/dye penetrant inspection followed by vacuum stress-relief annealing; (S3) subjecting the ring blank to core shaft/saddle forging on the flat-die hammer or rapid-forging press to obtain a crude forged ring; and (S4) subjecting the crude forged ring to vacuum recrystallization annealing to obtain a desired forged ring.

Abstract: An array substrate, a manufacturing method of the same, a display panel and a display device are provided. The array substrate includes a display region and a peripheral region around the display region, a photosensitive layer is in the display region and a peripheral circuit is in the peripheral region. The array substrate further includes an alignment film covering the photosensitive layer and the peripheral circuit. The array substrate further includes an insulating layer between the peripheral circuit and the alignment film. The alignment film is a photo alignment film, and the insulating layer is configured to absorb and/or reflect an alignment light adopted for performing photoalignment to obtain the alignment film.

Abstract: The present application provides a display panel, a. manufacturing method, a detection method, and a display device. The display panel includes a display area and a non-display area surrounding the display area. The non-display area includes: a crack detection line surrounding the display area; a screen control line; a plurality of switch signal lines; and a plurality of detection switches electrically connected at different positions to the crack detection line. Each detection switch is also connected to the screen control line and a respective switch signal line, and allows conduction between the crack detection line and the screen control line based on the switch signal input by the switch signal line, such that the screen control line drives the display panel to display according to the test signal input by the crack detection line.

Abstract: An antidepressant steroid compound and a preparation method and an application thereof; the structure of said compound is shown in formula (I), and the definition of each substituent is as described in the description and claims. Compound of the present invention may be used in the prevention, treatment, therapy or alleviation of a plurality of diseases and conditions such as depression.

Abstract: An array substrate, a manufacturing method of the same, a display panel and a display device are provided. The array substrate includes a display region and a peripheral region around the display region, a photosensitive layer is in the display region and a peripheral circuit is in the peripheral region. The array substrate further includes an alignment film covering the photosensitive layer and the peripheral circuit. The array substrate further includes an insulating layer between the peripheral circuit and the alignment film. The alignment film is a photo alignment film, and the insulating layer is configured to absorb and/or reflect an alignment light adopted for performing photoalignment to obtain the alignment film.

Abstract: The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy—induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.

Abstract: The present application provides a low load operating system for a refrigeration system having a compressor, a condenser, an expansion valve, and an evaporator. The low load operating system may include a hot gas bypass line extending from a discharge side of the compressor to a suction side of the compressor and a desuperheat line extending from upstream of the expansion valve to the suction side of the compressor.

Abstract: Described herein are methods and systems for identifying and/or treating subjects having cancer who are more likely to respond to treatment with an inhibitor of the transcription factor HIF-2?.