Abstract: The present disclosure provides engineered WNT agonists and methods of treating gastrointestinal disorders with modulators of the WNT signaling pathway.

Abstract: The present invention relates to an antiviral application of nucleoside analogs. Specifically, the present invention relates to uses of nucleoside analogs and a pharmaceutical composition thereof as: (a) inhibitors for inhibiting the replication of coronaviruses, influenza viruses, respiratory syncytial viruses, flaviviridae viruses, filoviridae viruses and/or porcine epidemic diarrhea virus (PEDV); and/or (b) medicines for treating and/or preventing and mitigating diseases caused by coronavirus, influenza virus, respiratory syncytial virus, flaviviridae virus, filoviridae virus and/or porcine epidemic diarrhea virus (PEDV) infections. The nucleoside analogs according to the invention may treat and/or prevent and mitigate respiratory infection, pneumonia (COVID-19) and other related diseases caused by 2019 novel coronavirus infection.

Abstract: The present invention provides Wnt pathway agonists and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of diseases.

Abstract: A method for reinforcing soft ground by post-grouting combined with pressurized vacuum preloading is proposed, by pre-burying prefabricated vertical drains and air-boosted pipes in granular material piles, and the air-boosted pipes are used as grouting pipes to reduce the number of times of piling, which not only improves the construction efficiency, but also reduces the structural disturbance of the soil and the influence of smear effect, thus reducing the impact on the radial permeability and the radial consolidation coefficients. The method does not use geotextile bags for granular materials, which can avoid the problem of forming a localized clogging area around the geotextile bags, and the method not only improves the efficiency of vacuum transfer in a pre-consolidation stage, but also improves the grouting effect in the later stage, effectively enhances the strength of soft soil and makes granular material piles and the surrounding soil form composite ground.

Abstract: The present utility model relates to a device for improving gas detection in a photoionization detector. A gas detector is provided. The device reduces interference of photoelectric noise on the reading of the gas detector for target gases such as volatile organic compounds.

Abstract: A quantitative evaluation method for integrity and damage evolution of a cement sheath in an oil-gas well is provided based on a fractal theory, an image processing technology, structural features and failure mechanisms of a casing-cement sheath-formation combination. The method uses correlations among fractal dimensions of casing-cement sheath interface morphology, cement sheath microscopic pore morphology, particle morphology of an initial blank group, and macroscopic mechanical properties including a radial cementing strength of the cement sheath interface, a tensile strength, and a compressive strength to quantitatively evaluate the integrity of the cement sheath of the blank group.

Abstract: A stability control method for a virtual synchronous generator (VSG) in a strong grid based on an inductance-current differential feedback is provided. A grid-connected topological structure of a VSG using the control method includes a direct-current (DC)-side voltage source, a three-phase inverter, a three-phase grid impedance and a three-phase grid. By controlling the VSG and controlling the inductance-current differential feedback, the method suppresses the oscillation of the output power from the VSG in the strong grid and implements the stable operation of an inner-loop-free VSG in the strong grid, without adding the physical inductance, increasing the cost of the filter and additionally providing a grid-side current sensor.

Abstract: The application relates to the field of wireless communication, and discloses a roaming method in a multi-link scenario, a multi-link device and a storage medium. The roaming method in the multi-link scenario includes: selecting a target network access device that meets a condition; disconnecting a logical entity on a secondary link of an original network access device from the original network access device; establishing a connection of the logical entity with the target network access device; determining a link through which the logical entity is connected with the target network access device as a primary link; and disconnecting a connection of the other logical entity other than the logical entity with the original network access device. The application realizes roaming of a terminal among different network access devices through link management and interactive control, ensuring service continuity and avoiding packet loss.

Abstract: The application discloses a method for connecting to a network access device, a terminal and a computer-readable storage medium. The method includes: transmitting an association request message or a reassociation request message to the network access device; receiving an association response message or a reassociation response message sent by the network access device, wherein the association response message or the reassociation response message includes parameters of AP-EHT Capabilities, EHT Operation, TWT Responder Support and TWT Required, and wherein the AP-EHT Capabilities includes a field of AP-ML Support and the EHT Operation includes a field of AP-Primary Link; reading contents of the association response message or the reassociation response message, and performing a multi-link operation on the basis of the contents.

Abstract: This application provides a BIER packet sending method. The method includes: receiving a BIER packet that is encapsulated using an IPv6 protocol and that is sent by a second forwarding device, where the BIER packet includes an IPv6 basic header and a BIER header, a destination address field in the IPv6 basic header is a first IPv6 address of the first forwarding device; determining, based on an identifier corresponding to a first IPv6 address in a forwarding table, to perform BIER forwarding on the BIER packet, where the identifier is used to indicate that the first IPv6 address is a destination address for BIER forwarding. In the technical solution provided in this application, a node may determine, based on the identifier of the first IPv6 address, to perform BIER forwarding on the BIER packet.

Abstract: A platform for processing a workpiece includes a transmission mechanism, a plurality of workstations and a plurality of movable vehicles. The transmission mechanism transports the workpiece to be processed to one of the plurality of workstations. Each movable vehicle includes a processing module and a docking interface adapted to connect with a docking station of each workstation. The movable vehicles are each adapted to move in and out of each workstation, and each processing module is adapted to process the workpiece transmitted to the workstation after the movable vehicle is moved in and positioned in the workstation.

Abstract: This disclosure provides an array substrate and a display device. In the array substrate, the pixel driving circuit includes a driving transistor, a first transistor and a second transistor. The driving transistor and the first transistor are P-type transistors, and the second transistor is N-type transistor. The array substrate also includes a base substrate, and a first conductive layer arranged at a side of the base substrate and including: a first conductive portion forming a gate electrode of the driving transistor; a first gate line at a side of the first conductive portion, a part of the first gate line being configured to form a gate electrode of the first transistor; and a second gate line at a side of the first gate line away from the first conductive portion, a part of the second gate line being configured to form a first gate electrode of the second transistor.

Abstract: The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy-induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.

Abstract: The present invention relates to an antiviral application of nucleoside analogs. Specifically, the present invention relates to uses of nucleoside analogs and a pharmaceutical composition thereof as: (a) inhibitors for inhibiting the replication of coronaviruses, influenza viruses, respiratory syncytial viruses, flaviviridae viruses, filoviridae viruses and/or porcine epidemic diarrhea virus (PEDV); and/or (b) medicines for treating and/or preventing and mitigating diseases caused by coronavirus, influenza virus, respiratory syncytial virus, flaviviridae virus, filoviridae virus and/or porcine epidemic diarrhea virus (PEDV) infections. The nucleoside analogs according to the invention may treat and/or prevent and mitigate respiratory infection, pneumonia (COVID-19) and other related diseases caused by 2019 novel coronavirus infection.

Abstract: A processing device in a memory sub-system traverses a plurality of management units of a memory device at a defined scan/read refresh frequency. For every management unit of the plurality of management units, the processing device identifies a page satisfying a lowest sensing overhead criterion, and senses data of the identified page without transferring the data out of the memory device. A non-transitory computer readable medium includes program instructions that when executed by a processing device, cause the processing device to perform operations of traversing a plurality of management units of a memory device at a defined scan/read refresh frequency. For every management unit, the processing device identifies a page satisfying a lowest sensing overhead criterion, and senses data of the identified page without transferring the data out of the memory device.

Abstract: The present disclosure relates to the technical field of composite coating preparation, in particular to a method for plasma-assisted and multi-step continuous preparation of a diffusion layer/amorphous carbon film composite coating and use thereof. In the present disclosure, a high-temperature plasma carburizing/nitriding technology and a low-temperature plasma carbon coating technology are combined by a plasma activation technology with argon ion under gradient cooling, and the surface of a material is activated by multiple bombardment on the surface of the material with high-energy argon ions. In this way, a cluster-like porous and loose structure on a surface of the diffusion layer is removed.

Abstract: A processing device in a memory sub-system performs a first media scan operation with respect to a plurality of memory pages addressable by the ordinary wordline, wherein each page of the plurality of memory pages is contained by a respective management unit, and responsive to determining that a value of a data state metric of a memory page of the plurality of memory page addressable by the ordinary wordline satisfies a specified condition, performs a first media management operation with respect to a management unit containing the memory page.

Abstract: Provided herein is a 7-genes signature, an algorithm to evaluate a patient's risk score, and methods of use thereof. The methods provided herein include methods of use of a risk score to predict lung cancer patient survival and lung cancer patient likelihood to respond to adjuvant chemotherapy.

Abstract: The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy-induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.

Abstract: The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy-induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.