Patents by Inventor Yang-Xin Fu

Yang-Xin Fu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody-light fusion products for cancer therapeutics
    Patent number: 8263081
    Abstract: Antibody-LIGHT fusion products or conjugates stimulate immunity against tumors and eradicate metastases. Tumor-specific antibodies coupled with LIGHT effectively target metastatic tumors and reduces cancer metastases.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: September 11, 2012
    Assignee: The University of Chicago
    Inventor: Yang-Xin Fu
  • METHODS AND COMPOSITIONS TO REDUCE LIVER DAMAGE ASSOCIATED WITH CONDITIONS OR THERAPIES THAT AFFECT THE IMMUNE SYSTEM
    Publication number: 20120014947
    Abstract: One side-effect arising from the use of antibodies against TNF receptor family members as therapeutics can be liver damage which precludes the completion of clinical trial. A novel LT-dependent pathway is described that mediates liver cell injury in several disease models.
    Type: Application
    Filed: July 15, 2011
    Publication date: January 19, 2012
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventor: Yang-Xin Fu
  • ANTIBODY-LIGHT FUSION PRODUCTS FOR CANCER THERAPEUTICS
    Publication number: 20110020340
    Abstract: Antibody-LIGHT fusion products or conjugates stimulate immunity against tumors and eradicate metastases. Tumor-specific antibodies coupled with LIGHT effectively target metastatic tumors and reduces cancer metastases.
    Type: Application
    Filed: May 14, 2008
    Publication date: January 27, 2011
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventor: Yang-Xin Fu
  • INCREASED T-CELL TUMOR INFILTRATION AND ERADICATION OF METASTASES BY MUTANT LIGHT
    Publication number: 20110014152
    Abstract: Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naïve T lymphocytes. Methods and compositions to elicit immune responses against tumors including tumor volume reduction and eradication of metastasis using mutant LIGHT are disclosed.
    Type: Application
    Filed: September 10, 2010
    Publication date: January 20, 2011
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventor: Yang-Xin Fu
  • Increased T-cell tumor infiltration and eradication of metastases by mutant light
    Patent number: 7811983
    Abstract: Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naïve T lymphocytes. Methods and compositions to elicit immune responses against tumors including tumor volume reduction and eradication of metastasis using mutant LIGHT are disclosed.
    Type: Grant
    Filed: August 7, 2006
    Date of Patent: October 12, 2010
    Assignee: The University of Chicago
    Inventor: Yang-Xin Fu
  • Increased T-cell tumor infiltration by mutant LIGHT
    Patent number: 7807784
    Abstract: Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naïve T lymphocytes. Methods and compositions to elicit immune responses against tumors including tumor volume reduction and reduced metastasis using mutant LIGHT are disclosed.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: October 5, 2010
    Assignee: The University of Chicago
    Inventor: Yang-Xin Fu
  • COMBINATION THERAPY FOR TREATING CANCER
    Publication number: 20090093429
    Abstract: The invention relates to treatment of primary and secondary tumors using a therapeutic combination including ionizing radiation and gene therapy comprising mutant-LIGHT. Methods of treating a tumor and inducing an anti-tumor immune response are also provided.
    Type: Application
    Filed: February 8, 2008
    Publication date: April 9, 2009
    Inventors: Yang-Xin Fu, Ralph R. Weichselbaum
  • Increased T-cell tumor infiltration and eradication of metastases by mutant LIGHT
    Publication number: 20090092640
    Abstract: Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naïve T lymphocytes. Methods and compositions to elicit immune responses against tumors including tumor volume reduction and eradication of metastasis using mutant LIGHT are disclosed.
    Type: Application
    Filed: August 7, 2006
    Publication date: April 9, 2009
    Applicant: The University of Chicago
    Inventor: Yang-Xin Fu
  • Treatment And Prophylaxis With 4-1BB-Binding Agents
    Publication number: 20090068193
    Abstract: Materials and Methods for using 4-1BB agonists to treat or prevent autoimmune disorders, lymphoproliferative diseases, and allergies are provided.
    Type: Application
    Filed: November 12, 2008
    Publication date: March 12, 2009
    Inventors: Lieping Chen, Yang-Xin Fu
  • Increased T-cell tumor infiltration by mutant light
    Publication number: 20050025754
    Abstract: Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naïve T lymphocytes. Methods and compositions to elicit immune responses against tumors including tumor volume reduction and reduced metastasis using mutant LIGHT are disclosed.
    Type: Application
    Filed: June 10, 2004
    Publication date: February 3, 2005
    Inventor: Yang-Xin Fu
  • Treatment and prophylaxis with 4-1BB-binding agents
    Publication number: 20040109847
    Abstract: Materials and methods for using 4-1BB agonists to treat or prevent autoimmune disorders, lymphoproliferative diseases, and allergies are provided.
    Type: Application
    Filed: July 14, 2003
    Publication date: June 10, 2004
    Inventors: Lieping Chen, Yang-Xin Fu