Abstract: The present invention relates to a targeted hydrophobic anti-tumor drug nanoformulation, which comprises a hydrophobic anti-tumor drug and a carrier with a mass ratio of 1:4-32.5, wherein the carrier is composed of 37.5-95.3 wt % albumin and 4.7-62.5 wt % hyaluronic acid-albumin conjugate, and the hyaluronic acid-albumin conjugate is prepared by albumin and hyaluronic acid with a molar ratio of 1:1-20. A preparation method of the nanoformulation comprises: preparing hyaluronic acid-albumin conjugate; formulating carrier solution; formulating drug solution; and preparing nanoformulation. The nanoformulation has even particle size distribution and good dispersibility, is stable without aggregating. The particle size of the lyophilized nanoformulation after being redissolved substantially remains unchanged, the yield of the nanoformulation is high and the efficacy is good after being filtered by a millipore filter (0.22 ?m).

Abstract: Disclosed is an endoscope with an enlargeable distal end, including an inserting portion and an endoscope main body. The inserting portion includes a housing, a working cavity, a camera, and an wire band. The working cavity, the camera and the wire band are all disposed in the housing. One end of the wire band is connected to the camera, and the other end the wire band passes through the housing to be connected to the endoscope main body. The camera is arranged at a distal end in the housing, where there is provided a notch. The working cavity or the camera can extend out from or retract back into the notch. When the working cavity or the camera extends out from the notch, the working cavity and the camera are situated side by side. The endoscope with the enlargeable distal end can achieve the enlargement and retraction of the distal end of the endoscope.

Abstract: A method for preparing a lisinopril intermediate is provided. The method includes: treating (R)-hydroxy-4-phenylbutyrate with sulfonyl chloride in an organic solvent in the presence of a base to obtain a solution of sulfonate; reacting the obtained solution with a salt of trifluoroacetyl lysine; and obtaining a N2-[1-(S)-alkoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine by separating after the reaction is completed. The method provided has a shorter synthesis route, is easy to operate, has a low cost, and is suitable for industrial production.

Abstract: An object detection system includes color and infrared cameras, a controller-circuit, and instructions. The color and infrared cameras are configured to output respective color image and infrared image signals. The controller-circuit is in communication with the cameras, and includes a processor and a storage medium. The processor is configured to receive and transform the color image and infrared image signals into classification and location data associated with a detected object. The instructions are stored in the at least one storage medium and executed by the at least one processor, and are configured to utilize the color image and infrared image signals to form respective first and second maps. The first map has a first plurality of layers, and the second map has a second plurality of layers. Selected layers from each are paired and fused to form a feature pyramid that facilitates formulation of the classification and location data.

Abstract: Lipid-based probes and systems therewith to capture and isolate extracellular vesicles from a sample are disclosed. The system can include a labelling probe-capture probe combination or an immobilized labelling probe on a surface of a substrate or a device including the immobilized labelling probe on a surface of a substrate. The labelling probe can include a lipid tail for insertion in the lipid bilayer membrane of extracellular vesicles. The labelling probe can further include a tag that can be readily combine with a capture probe or a high affinity component to bind to a substrate surface to immobilize the labelling probe, and a spacer between the lipid tail and tag or high affinity component.

Abstract: The disclosure discloses a method, apparatus and system for detecting multi-mode electromagnetic acoustic and magnetic flux leakage and a sensor. The method comprises: S102, receiving an operation instruction for detecting an object to be detected, the operation instruction is used for controlling a detection sensor to enter into any one or more of working modes as follows: magnetic flux leakage detection, ultrasonic bulk wave detection, ultrasonic guided wave detection and surface wave detection; S104, controlling the detection sensor to output a corresponding detection signal according to the operation instruction; and S106, detecting the object to be detected on the basis of the detection signal. The technical solution achieves a purpose of using one sensor to realize various detection modes, such as magnetic flux leakage and electromagnetic acoustic modes, reduces complexity and cost of a detection system, and improves detection efficiency.

Abstract: A method for preparing a lisinopril intermediate is provided. The method includes: treating (R)-hydroxy-4-phenylbutyrate with sulfonyl chloride in an organic solvent in the presence of a base to obtain a solution of sulfonate; reacting the obtained solution with a salt of trifluoroacetyl lysine; and obtaining a N2-[1-(S)-alkoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine by separating after the reaction is completed. The method provided has a shorter synthesis route, is easy to operate, has a low cost, and is suitable for industrial production.

Abstract: Techniques are described for provisioning Wi-Fi network connectivity for a wireless device without requiring a user to provide network credentials to allow the wireless device to establish a network connection. In some implementations, a method is performed by a computing device to provision a wireless network connection. A MAC address associated with a property is obtained. A temporary network credential for the wireless device is determined based on the MAC Address of the wireless device. The temporary network credential permits the wireless device to connect to a temporary network. The temporary network credential for the wireless device is available over the temporary network. A determination that the wireless device has connected to the temporary network using the temporary network credential for the wireless device is made. An instruction is transmitted to the wireless device over the temporary network in response to the determination.

Abstract: A rotatory energy recycling control device for a hydraulic excavator, comprising: an oil line selector valve (1), a direction selector valve (2), a sequencing valve (3), a one-way valve (4) and an overflow valve (5); two oil inlets of the oil line selector valve (1) are respectively connected to an opening A and an opening B of a rotary motor; an oil outlet of the oil line selector valve (1) is connected to an inlet of the direction selector valve (2); an outlet of the direction selector valve (2) is connected to an net of the sequencing valve (3); a drainage port of the sequencing valve (3) is connected to an oil tank; an outlet of the sequencing valve (3) and an net of the one-way valve (4) communicate with the overflow valve (5): the outlet of the one-way valve (4) is connected to an energy storage and utilization device; and an outlet of the overflow valve (5) is connected to the oil tank.

Abstract: The whole preparation process of the sustained-release microparticles is at normal or low temperature, which is highly advantageous for the preparation of a polymer-based composition from a high-temperature-sensitive drug, particularly a protein, nucleic acid and peptide drug, and the bioactivity of the active substance can be maintained to the greatest extent throughout the process compared to the disclosed technology; at the same time, the prepared sustained-release microparticles have an excellent sustained-release effect close to zero order, and the drug concentration is stabilized during the release, which overcomes the defects that the microparticles obtained by the conventional S/O/W process of pre-preparing the drug microparticles have no drug release in the earlier stage and a rapid release of the drug in the later stage; and in addition, the sustained-release microparticles have higher drug loading rate and drug encapsulation rate.

Abstract: In the present invention, the whole preparation process of the sustained-release microparticles is at normal or low temperature, which is highly advantageous for the preparation of a polymer-based composition from a high-temperature-sensitive drug, particularly a protein, nucleic acid and peptide drug, and the bioactivity of the active substance can be maintained to the greatest extent throughout the process compared to the disclosed technology; at the same time, the prepared sustained-release microparticles have an excellent sustained-release effect close to zero order, and the drug concentration is stabilized during the release, which overcomes the defects that the microparticles obtained by the conventional S/O/W process of pre-preparing the drug microparticles have no drug release in the earlier stage and a rapid release of the drug in the later stage; and in addition, the sustained-release microparticles have higher drug loading rate and drug encapsulation rate.

Abstract: The present invention relates to the video surveillance field, and discloses a trunk management method and apparatus for video surveillance systems. In the present invention, the connection priority of a surveillance equipment is the highest priority amon/between priorities of all clients, when multiple clients with different priorities access the same surveillance equipment. The connection priority of the surveillance equipment is set as the priority of a new client, if the new client accesses the surveillance equipment and the priority of the new client is higher than the connection priority of the surveillance equipment; the connection priority of the surveillance equipment is remained unchanged, if the priority of the new client is not higher than the connection priority of the surveillance equipment.

Abstract: In a direct mode two-way radio frequency communications system having a plurality of direct mode traffic channels, a first direct mode subscriber unit (DMSU) monitors a preconfigured direct mode control channel (DMCC), the DMCC being a channel that is monitored by all DMSUs that are idle in the system, and which is time divided into slots including traffic channel status slots (TCSSs), each TCSS associated with another physical direct mode traffic channel (DMTC) in the communication system. Responsive to detecting a request to initiate a new call, the DMSU selects a first DMTC on which to transmit the call, transmits during the next TCSS of the DMCC associated with the selected DMTC a header indicating the first DMSU's intention to transmit a new call on the selected DMTC, and subsequently switches to the selected DMTC and transmits the new call.

Abstract: A radio receives a call including a call include bitmask (CIB). The radio retrieves a call include list (CIL) that, for each bit position in the CIB, maps the bit position to one of a radio identifier, a talk group identifier, and a sub-CIL. The radio determines that one bit position in the CIB is set to a value indicating that a radio associated with a radio identifier mapped to the bit position in the CIB via the CIL or to a talk group identifier mapped to the bit position in the CIB via the CIL are to be included in the call. The radio matches its identifier to the radio identifier mapped to the bit position or matches a talk group to which it subscribes to the talk group identifier mapped to the at least one bit position and unmutes the call.

Abstract: A rotatory energy recycling control device for a hydraulic excavator, comprising: an oil line selector valve (1), a direction selector valve (2), a sequencing valve (3), a one-way valve (4) and an overflow valve (5); two oil inlets of the oil line selector valve (1) are respectively connected to an opening A and an opening B of a rotary motor; an oil outlet of the oil line selector valve (1) is connected to an inlet of the direction selector valve (2); an outlet of the direction selector valve (2) is connected to an net of the sequencing valve (3); a drainage port of the sequencing valve (3) is connected to an oil tank; an outlet of the sequencing valve (3) and an net of the one-way valve (4) communicate with the overflow valve (5): the outlet of the one-way valve (4) is connected to an energy storage and utilization device; and an outlet of the overflow valve (5) is connected to the oil tank.

Abstract: A radio receives a call including a call include bitmask (CIB). The radio retrieves a call include list (CIL) that, for each bit position in the CIB, maps the bit position to one of a radio identifier, a talk group identifier, and a sub-CIL. The radio determines that one bit position in the CIB is set to a value indicating that a radio associated with a radio identifier mapped to the bit position in the CIB via the CIL or to a talk group identifier mapped to the bit position in the CIB via the CIL are to be included in the call. The radio matches its identifier to the radio identifier mapped to the bit position or matches a talk group to which it subscribes to the talk group identifier mapped to the at least one bit position and unmutes the call.

Abstract: In a direct mode two-way radio frequency communications system having a plurality of direct mode traffic channels, a first direct mode subscriber unit (DMSU) monitors a preconfigured direct mode control channel (DMCC), the DMCC being a channel that is monitored by all DMSUs that are idle in the system, and which is time divided into slots including traffic channel status slots (TCSSs), each TCSS associated with another physical direct mode traffic channel (DMTC) in the communication system. Responsive to detecting a request to initiate a new call, the DMSU selects a first DMTC on which to transmit the call, transmits during the next TCSS of the DMCC associated with the selected DMTC a header indicating the first DMSU's intention to transmit a new call on the selected DMTC, and subsequently switches to the selected DMTC and transmits the new call.

Abstract: The present invention relates to the video surveillance field, and discloses a trunk management method and apparatus for video surveillance systems. In the present invention, the connection priority of a surveillance equipment is the highest priority amon/between priorities of all clients, when multiple clients with different priorities access the same surveillance equipment. The connection priority of the surveillance equipment is set as the priority of a new client, if the new client accesses the surveillance equipment and the priority of the new client is higher than the connection priority of the surveillance equipment; the connection priority of the surveillance equipment is remained unchanged, if the priority of the new client is not higher than the connection priority of the surveillance equipment.

Abstract: A method for image linear structure detection in medical imaging. The method includes locating microcalcification (mcc) candidate spots in a mammographic image; forming candidate clusters; assigning ranks to the candidate clusters; identifying linear structures in the neighborhood where the candidate clusters reside; and altering the ranks of the candidate clusters for which linear structures have been identified in the neighborhood.

Abstract: A method for image linear structure detection in medical imaging. The method includes locating microcalcification (mcc) candidate spots in a mammographic image; forming candidate clusters; assigning ranks to the candidate clusters; identifying linear structures in the neighborhood where the candidate clusters reside; and altering the ranks of the candidate clusters for which linear structures have been identified in the neighborhood.