Abstract: Provided herein are safe harbor loci that can be utilized as sites for genetic modification. Safe harbor loci of the disclosure are shown to support sustained transgene expression with minimal silencing, and minimal impact on local or global gene expression. Safe harbor loci disclosed herein can be used in various genetic and cell engineering applications.

Abstract: A lighting apparatus includes a light source plate, LED modules and a driver module. The light source plate includes a substrate layer, a wiring layer and a protection layer. The substrate layer is made of metal material. LED modules are disposed on a top side of the light source plate. The driver module is disposed on the top side of the light source plate. The LED modules and the driver module are electrically connected via the wiring layer. The driver module includes an AC-DC converter, a regulator, a controller, a current source and an oscillation wave removal circuit. The controller controls the current source to generate driving currents to the LED modules. The oscillation wave removal circuit is coupled to the AC-DC converter for suppressing a sudden abnormal peak voltage from the AC-DC converter.

Abstract: A lighting apparatus includes a first light source, a second light source, a third light source, a driver, a first controller, a second controller and a main controller. The first light source emits a first light with a first color temperature. The second light source emits a second light with a second color temperature. The third light source emits a third light with a third color temperature. The driver generates a first driving current to the first light source, generates a second driving current to the second light source, and generates a third driving current to the third light source.

Abstract: A lighting apparatus includes a bridge circuit, a current source, a first LED module, a second LED module and a switch. The bridge circuit is used for rectifying an input AC power to generate a DC power. The current source receives the DC power to generate a driving current. The first LED module emits a first light of a first color temperature. The second LED module emits a second light of a second color temperature. The switch is coupled to the current source to change at least a resistance parameter corresponding to a current ratio between the first LED module and the second LED module to generate a mixed light of a mixed color temperature.