Patents by Inventor Yanghui Guo
Yanghui Guo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230348467Abstract: The present invention relates to heteroaryl derivatives, preparation methods therefor, and applications thereof in medicine. Specifically, the present invention relates to a heteroaryl derivative represented by general formula (AI), a preparation method therefor, and a pharmaceutically acceptable salt, and use thereof as a therapeutic agent, in particular, as an SHP2 allosteric inhibitor, wherein the definition of substituents in general formula (AI) is the same as that in the description.Type: ApplicationFiled: January 12, 2021Publication date: November 2, 2023Applicants: Zhejiang Hisun Pharmaceutical Co., Ltd., Hisun AccuRay Therapeutics Co., Ltd.Inventors: Xiangui Huang, Yanghui Guo, Zongxing Qiu, Pingyan Bie, Weiwei Liao, Qingyan Yan, Weichao Shen, Hai Cao, Qingna Xing, Xin Wang, Qi Cao, Lichen Meng, Nuoyi Wu, Wenpeng Li, Cheng Ye, Taishan Hu, Lei Chen
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Publication number: 20230242522Abstract: The present invention relates to a pharmaceutically acceptable salt of (S)-2-(6-fluorobenzo[d]oxazol-2-yl)-6-methoxy-5-((5-methoxypyridin-2-yl))methoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, a preparation method therefor, a pharmaceutical composition comprising the pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, in particular as an angiotensin II type-2 receptor antagonist.Type: ApplicationFiled: June 25, 2021Publication date: August 3, 2023Applicants: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD., SHANGHAI ARYL PHARMTECH CO., LTD.Inventors: Yanghui GUO, Lichen MENG, Xiangui HUANG, Weiwei LIAO, Yongxiang GONG, Daiwang XU, Taishan HU, Lei CHEN
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Publication number: 20220227699Abstract: The present invention relates to aromatic ring or heteroaromatic ring derivatives, a preparation method therefor and applications thereof in medicine. Specifically, the present invention relates to aromatic ring or heteroaromatic ring derivatives represented by general formula (I), a preparation method therefor and pharmaceutically acceptable salts thereof, as well as a use thereof as therapeutic agents, especially uses as angiotensin II type 2 receptor (AT2R) antagonists, wherein the definition of each substituent in the general formula (I) is the same as the definition thereof in the description.Type: ApplicationFiled: April 1, 2020Publication date: July 21, 2022Applicants: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD., HISUN ACCURAY THERAPEUTICS CO., LTD.Inventors: Yanghui GUO, Weiwei LIAO, Lichen MENG, Taishan HU, Lei CHEN, Guoping JIANG
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Patent number: 11384097Abstract: Provided are a tetrahydroisoquinoline derivative, a preparation method therefor and an application thereof in medicine. In particular, provided are a tetrahydroisoquinoline derivative represented by general formula (I), a preparation method therefor and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as an angiotensin II type 2 receptor (AT2R) antagonist, wherein definitions of substituent groups in the general formula (I) are the same as definitions in the description.Type: GrantFiled: June 18, 2019Date of Patent: July 12, 2022Assignee: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.Inventors: Yanghui Guo, Xiangui Huang, Weiwei Liao, Lichen Meng, Taishan Hu, Lei Chen, Guoping Jiang
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Publication number: 20210277021Abstract: Provided are a tetrahydroisoquinoline derivative, a preparation method therefor and an application thereof in medicine. In particular, provided are a tetrahydroisoquinoline derivative represented by general formula (I), a preparation method therefor and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as an angiotensin II type 2 receptor (AT2R) antagonist, wherein definitions of substituent groups in the general formula (I) are the same as definitions in the description.Type: ApplicationFiled: June 18, 2019Publication date: September 9, 2021Applicant: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.Inventors: Yanghui GUO, Xiangui HUANG, Weiwei LIAO, Lichen MENG, Taishan HU, Lei CHEN, Guoping JIANG
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Patent number: 10287309Abstract: The present invention relates to a disaccharide intermediate and a synthesis method thereof, relates to the chemical pharmaceutical field, and more specifically relates to a method for preparing a disaccharide segment of a key intermediate for chemically synthesizing heparin and heparinoid compounds. Disclosed are a new disaccharide intermediate and three methods for synthesizing the disaccharide intermediate, that is, compounds of a formula (4) and glucopyranose protected by different anomeric carbon are made to react in the presence of an active agent, to obtain the disaccharide intermediate. According to the technical solutions of the present invention, synthetic raw materials are easy to obtain, have a mild reaction condition, and are suitable for industrialized production.Type: GrantFiled: April 28, 2014Date of Patent: May 14, 2019Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Yanghui Guo, Junhui Zhou, Qingfeng Cai, Hegeng Wei, Hua Bai, Fei Long, Yue Zhang, Yingqiu Wu
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Publication number: 20180346506Abstract: The present invention relates to a method for preparing Sofosbuvir crystal form-6. The method is simple in operation, stable in process condition, good in reproducibility, high in yield rate and high in purity, viscous gel-type products are not formed during the process, the problem of blocking of a discharge port is solved, and the method is suitable for mass industrial production and has high economic value.Type: ApplicationFiled: November 11, 2015Publication date: December 6, 2018Applicant: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.Inventors: Yanghui GUO, Shiguo ZHAO, Yue ZHANG, Liang ZHANG, Zhiqing YANG, Jian CHAI
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Patent number: 9624315Abstract: The present invention relates to a process of a chemically synthetic drug, and in particular, to a new intermediate of a heparin pentasaccharide and a preparation method thereof. The process has high reaction efficiency, and an easy reaction operation. The reaction intermediate is easy to be purified, and is appropriate for an industrialization production.Type: GrantFiled: April 2, 2013Date of Patent: April 18, 2017Assignee: Zhejiang Hisum Pharmaceutical Co., Ltd.Inventors: Yanghui Guo, Hegeng Wei, Hua Bai, Yingqiu Wu, Yue Zhang, Junhui Zhou, Yili Ding, Lingwei Bai, Shibao Yang
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Publication number: 20160264609Abstract: The present invention relates to a disaccharide intermediate and a synthesis method thereof, relates to the chemical pharmaceutical field, and more specifically relates to a method for preparing a disaccharide segment of a key intermediate for chemically synthesizing heparin and heparinoid compounds. Disclosed are a new disaccharide intermediate and three methods for synthesizing the disaccharide intermediate, that is, compounds of a formula (4) and glucopyranose protected by different anomeric carbon are made to react in the presence of an active agent, to obtain the disaccharide intermediate. According to the technical solutions of the present invention, synthetic raw materials are easy to obtain, have a mild reaction condition, and are suitable for industrialized production.Type: ApplicationFiled: April 28, 2014Publication date: September 15, 2016Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Yanghui Guo, Junhui Zhou, Qingfeng Cai, Hegeng Wei, Hua Bai, Fei Long, Yue Zhang, Yingqiu Wu
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Publication number: 20150299340Abstract: The present invention relates to a process of a chemically synthetic drug, and in particular, to a new intermediate of a heparin pentasaccharide and a preparation method thereof. The process has high reaction efficiency, and an easy reaction operation. The reaction intermediate is easy to be purified, and is appropriate for an industrialization production.Type: ApplicationFiled: April 2, 2013Publication date: October 22, 2015Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Yanghui Guo, Hegeng Wei, Hua Bai, Yingqiu Wu, Yue Zhang, Junhui Zhou, Yili Ding, Lingwei Bai, Shibao Yang
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Publication number: 20150284419Abstract: Disclosed is a process for chemically synthesizing a pharmaceutical intermediate, in particular to a novel intermediate and novel process for synthesizing an anticoagulant drug fondaparinux sodium intermediate—full protection heparin pentasaccharide. The process has a high reaction efficiency and a simple reaction operation, and enables the reaction intermediate to be easily purified, thus being suitable for the industrialized production of the full protection heparin pentasaccharide.Type: ApplicationFiled: May 25, 2012Publication date: October 8, 2015Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Yili Ding, Yanghui Guo, Hua Bai, Yingqiu Wu, Xuan Yang, Qingyan Yan, Jian Chai
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Publication number: 20150065700Abstract: Provided is a method for preparing 3-O-benzyl-1,2-O-isopropylidene-?-L-idofuranose, which comprises: (1) protecting hydroxyl of 3-O-benzyl-1,2-O-isopropylidene-?-D-glucofuranose (III) by benzoyl and methylsulfonyl to obtain 6-O-benzoyl-3-O-benzyl-1,2-O-isopropylidene-5-O-methylsulfonyl-?-D-glucofuranose (V); (2) subjecting compound (V) to a cyclization reaction under an alkaline condition to obtain 5,6-epoxy-3-O-benzyl-1,2-O-isopropylidene-?-L-idofuranose (VI); and (3) subjecting compound (VI) to a ring-opening reaction to obtain 3-O-benzyl-1,2-O-isopropylidene-?-L-idofuranose.Type: ApplicationFiled: February 22, 2013Publication date: March 5, 2015Applicant: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.Inventors: Yanghui Guo, Hegeng Wei, Junhui Zhou, Yingqiu Wu, Yue Zhang, Hua Bai, Liang He, Yili Ding