Abstract: A two-way radio device with combined mobile communication function comprises at least a radio transceiver module, a 2G/3G transceiver module, a control processor, an audio processing module, a memory, a display, a button set and a power supply module. Accordingly by executing a manual operation mode or an automatic operation mode of the device, one of a radio communication function and a mobile communication function of the device is selected to be enabled so as to achieve voice and data communications with one of radio system subscribers or 2G/3G system subscribers. Besides, the device can also execute a transfer operation mode to transfer and forward communications between the radio system subscribers, or between the radio system subscribers and the 2G/3G system subscribers.