Abstract: The present disclosure relates to the field of CO2 geological sequestration, and provides a whole-process multi-parameter monitoring device and method for simulating CO2 geological sequestration and use thereof. A large-scale reactor body is developed, and a geological reservoir at a depth of 800 to 3000 meters is simulated. A modular built-in model device is researched and developed, a multi-type and variable-structure reservoir remodeling technology is developed, and mutual coupling of modules can be achieved. The design idea of separating the pressure reactor from the built-in sample model is adopted in the device. The confining pressure, the pore pressure, the temperature gradient, and the axial load of the device can be independently controlled through a temperature control mechanism and a loading mechanism respectively, so that the restoration of the state of in-situ stresses in the reservoir is realized.