Abstract: Instruction cache behavior and branch prediction are used to improve the functionality of a computing device by profiling branching instructions in an instruction cache to identify likelihoods of proceeding to a plurality of targets from the branching instructions; identifying a hot path in the instruction cache based on the identified likelihoods; and rearranging the plurality of targets relative to one another and associated branching instructions so that a first branching instruction that has a higher likelihood of proceeding to a first hot target than to a first cold target and that previously flowed to the first cold target and jumped to the first hot target instead flows to the first hot target and jumps to the first cold target.

Abstract: Instruction cache behavior and branch prediction are used to improve the functionality of a computing device by profiling branching instructions in an instruction cache to identify likelihoods of proceeding to a plurality of targets from the branching instructions; identifying a hot path in the instruction cache based on the identified likelihoods; and rearranging the plurality of targets relative to one another and associated branching instructions so that a first branching instruction that has a higher likelihood of proceeding to a first hot target than to a first cold target and that previously flowed to the first cold target and jumped to the first hot target instead flows to the first hot target and jumps to the first cold target.

Abstract: Correlating two storage rings based on an access rate for an object. A correlative dual hash ring includes a first ring of storage drives and a second ring of storage drives. Objects and replicas are allocated to either a first ring or a second ring.

Abstract: Correlating two storage rings based on an access rate for an object. A correlative dual hash ring includes a first ring of storage drives and a second ring of storage drives. Objects and replicas are allocated to either a first ring or a second ring.

Abstract: Correlating two storage rings based on an access rate for an object. A correlative dual hash ring includes a first ring of storage drives and a second ring of storage drives. Objects and replicas are allocated to either a first ring or a second ring.

Abstract: A cache driver, a host bus adapter and methods used by them are provided. The method used by the cache driver includes: receiving a first I/O request for accessing data, and sending a second I/O request to a host bus adapter (HBA). The cache driver sends the second I/O request in response to determining that the first I/O request accesses hot data on a HDD. In that case, the second I/O request is a request to the HBA to send a third I/O request to both the HDD and an SSD. The method used by the HBA includes: receiving a second I/O request from a cache driver. The second I/O request is a request to the HBA to send a third I/O request to both a HDD and an SSD. The HBA then sends the third I/O request.

Abstract: A cache driver, a host bus adapter and methods used by them are provided. The method used by the cache driver includes: receiving a first I/O request for accessing data, and sending a second I/O request to a host bus adapter (HBA). The cache driver sends the second I/O request in response to determining that the first I/O request accesses hot data on a HDD. In that case, the second I/O request is a request to the HBA to send a third I/O request to both the HDD and an SSD. The method used by the HBA includes: receiving a second I/O request from a cache driver. The second I/O request is a request to the HBA to send a third I/O request to both a HDD and an SSD. The HBA then sends the third I/O request.

Abstract: The methods of the present application describe that introduction of physiologically relevant miRNAs can enhance or modulate somatic cell reprogramming, generating induced pluripotent stem cells (iPS cells). These miRNAs did not further enhance reprogramming in the presence of cMyc. Furthermore, unlike previously described methods of generating iPS cells, such as through the introduction of genetic elements using viruses, the methods of the present invention reduce the risk of activating oncogenes in the iPS cells. The methods of the invention generate iPS cells that can be free of genetic modifications and thus have greater potential for use as therapeutic agents than those generated by existing methods.

Abstract: The methods of the present application describe that introduction of physiologically relevant miRNAs can enhance or modulate somatic cell reprogramming, generating induced pluripotent stem cells (iPS cells). These miRNAs did not further enhance reprogramming in the presence of cMyc. Furthermore, unlike previously described methods of generating iPS cells, such as through the introduction of genetic elements using viruses, the methods of the present invention reduce the risk of activating oncogenes in the iPS cells. The methods of the invention generate iPS cells that can be free of genetic modifications and thus have greater potential for use as therapeutic agents than those generated by existing methods.

Abstract: The key obstacle for current resuscitation is the acutely limited time window. The major reason for the limited time window is that the brain and spinal cord are extremely vulnerable to hypoxic-ischemic insult. A method and a lymph-like fluid composition for resuscitation of cardiac arrest are provided. The method includes steps of inhibiting CSF production, removing CSF, replacing the CSF with invented lymph-like fluid composition plus conventional CPR. The lymph-like fluid composition includes polypeptides, insulin, elevated magnesium concentration and ATP in artificial CSF.