Patents by Inventor Yangming Zhang
Yangming Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240351966Abstract: Provided are a class of alkylphenol compounds and a preparation method therefor. Specifically provided are a new alkyl polyphenol compound as represented by chemical formula I, and a preparation method therefor and the use thereof in the treatment of metabolic syndrome.Type: ApplicationFiled: May 11, 2022Publication date: October 24, 2024Inventors: Fajun NAN, Jingya LI, Zheng ZHANG, Yanan DUAN, Yangming ZHANG, Dandan CHEN, Chengqiu DAI
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Patent number: 11593594Abstract: A data processing method for a convolutional neural network includes: (a) obtaining a matrix parameter of an eigenmatrix; (b) reading corresponding data in an image data matrix from a first buffer space based on the matrix parameter through a first bus, to obtain a next to-be-expanded data matrix, and sending and storing the to-be-expanded data matrix to a second preset buffer space through a second bus; (c) reading the to-be-expanded data matrix, and performing data expansion on the to-be-expanded data matrix to obtain expanded data; (d) reading a preset number of pieces of unexpanded data in the image data matrix, sending and storing the unexpanded data to the second preset buffer space, and updating, based on the unexpanded data, the to-be-expanded data matrix; and (e). repeating (c) and (d) until all data in the image data matrix is completely read out on the to-be-expanded data matrix.Type: GrantFiled: November 9, 2021Date of Patent: February 28, 2023Assignee: TENCENT TECHNOLOGY (SHENZHEN) COMPANY LIMITEDInventors: Yangming Zhang, Jianlin Gao, Heng Zhang
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Patent number: 11449576Abstract: Embodiments of this application provide a convolution operation processing method and a related product. The integrated chip includes a control unit, at least one convolutional processing element, an input cache, and an output cache. The control unit loads a sectioned convolution kernel and sectioned convolution input data into the input cache, the sectioned convolution kernel being generated by sectioning a convolution kernel and including a plurality of convolution kernel segments, and the sectioned convolution input data being generated by sectioning convolution input data and including a plurality of convolution input data segments; and the at least one convolutional processing element performs a sectioned convolution operation on the sectioned convolution kernel and the sectioned convolution input data to obtain a sectioned convolution result, and stores the sectioned convolution result into the output cache.Type: GrantFiled: November 8, 2019Date of Patent: September 20, 2022Assignee: Tencent Technology (Shenzhen) Company LimitedInventors: Heng Zhang, Yangming Zhang
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Publication number: 20220067447Abstract: A data processing method for a convolutional neural network includes: (a) obtaining a matrix parameter of an eigenmatrix; (b) reading corresponding data in an image data matrix from a first buffer space based on the matrix parameter through a first bus, to obtain a next to-be-expanded data matrix, and sending and storing the to-be-expanded data matrix to a second preset buffer space through a second bus; (c) reading the to-be-expanded data matrix, and performing data expansion on the to-be-expanded data matrix to obtain expanded data; (d) reading a preset number of pieces of unexpanded data in the image data matrix, sending and storing the unexpanded data to the second preset buffer space, and updating, based on the unexpanded data, the to-be-expanded data matrix; and (e). repeating (c) and (d) until all data in the image data matrix is completely read out on the to-be-expanded data matrix.Type: ApplicationFiled: November 9, 2021Publication date: March 3, 2022Inventors: Yangming ZHANG, Jianlin GAO, Heng ZHANG
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Patent number: 11222240Abstract: A data processing method for a convolutional neural network includes: (a) obtaining a matrix parameter of an eigenmatrix; (b) reading corresponding data in an image data matrix from a first buffer space based on the matrix parameter through a first bus, to obtain a next to-be-expanded data matrix, and sending and storing the to-be-expanded data matrix to a second preset buffer space through a second bus; (c) reading the to-be-expanded data matrix, and performing data expansion on the to-be-expanded data matrix to obtain expanded data; (d) reading a preset number of pieces of unexpanded data in the image data matrix, sending and storing the unexpanded data to the second preset buffer space, and updating, based on the unexpanded data, the to-be-expanded data matrix; and (e). repeating (c) and (d) until all data in the image data matrix is completely read out on the to-be-expanded data matrix.Type: GrantFiled: January 17, 2019Date of Patent: January 11, 2022Assignee: TENCENT TECHNOLOGY (SHENZHEN) COMPANY LIMITEDInventors: Yangming Zhang, Jianlin Gao, Heng Zhang
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Patent number: 11192916Abstract: Disclosed are a pentacyclic triterpene compound as shown in general formula (I) and a preparation method therefor. The compound has an effective antagonistic effect on FXR receptors.Type: GrantFiled: September 17, 2018Date of Patent: December 7, 2021Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCESInventors: Fajun Nan, Xin Xie, Chenlu Zhang, Shimeng Guo, Yangming Zhang, Siwei Wang
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Patent number: 10766889Abstract: The invention describes an aryl-2,2?-tandem bisthiazole compound and a preparation method and the use thereof. In particular, disclosed in the present invention are an aryl-2,2?-tandem bisthiazole compound with the structure as shown in general formula I and the preparation method thereof and use thereof as a histone deacetylase inhibitor in the preparation of antitumor drugs.Type: GrantFiled: August 24, 2017Date of Patent: September 8, 2020Assignee: Shanghai Institute of Materia Medica, Chinese Academy of SciencesInventors: Fajun Nan, Jia Li, Jian Ding, Meiyu Geng, Yangming Zhang, Yi Chen, Yubo Zhou, Chaojun Gong, Mingbo Su, Anhui Gao
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Publication number: 20200231623Abstract: Disclosed are a pentacyclic triterpene compound as shown in general formula (I) and a preparation method therefor. The compound has an effective antagonistic effect on FXR receptors.Type: ApplicationFiled: September 17, 2018Publication date: July 23, 2020Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCESInventors: Fajun NAN, Xin XIE, Chenlu ZHANG, Shimeng GUO, Yangming ZHANG, Siwei WANG
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Publication number: 20200074288Abstract: Embodiments of this application provide a convolution operation processing method and a related product. The integrated chip includes a control unit, at least one convolutional processing element, an input cache, and an output cache. The control unit loads a sectioned convolution kernel and sectioned convolution input data into the input cache, the sectioned convolution kernel being generated by sectioning a convolution kernel and including a plurality of convolution kernel segments, and the sectioned convolution input data being generated by sectioning convolution input data and including a plurality of convolution input data segments; and the at least one convolutional processing element performs a sectioned convolution operation on the sectioned convolution kernel and the sectioned convolution input data to obtain a sectioned convolution result, and stores the sectioned convolution result into the output cache.Type: ApplicationFiled: November 8, 2019Publication date: March 5, 2020Applicant: Tencent Technology (Shenzhen) Company LimitedInventors: Heng ZHANG, Yangming ZHANG
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Publication number: 20190211005Abstract: The invention describes an aryl-2,2?-tandem bisthiazole compound and a preparation method and the use thereof. In particular, disclosed in the present invention are an aryl-2,2?-tandem bisthiazole compound with the structure as shown in general formula I and the preparation method thereof and use thereof as a histone deacetylase inhibitor in the preparation of antitumor drugs.Type: ApplicationFiled: August 24, 2017Publication date: July 11, 2019Inventors: Fajun NAN, Jia LI, Jian DING, Meiyu GENG, Yangming ZHANG, Yi CHEN, Yubo ZHOU, Chaojun GONG, Mingbo SU, Anhui GAO
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Patent number: 10316008Abstract: The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.Type: GrantFiled: January 12, 2018Date of Patent: June 11, 2019Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCESInventors: Fajun Nan, Min Li, Zhaobing Gao, Yangming Zhang, Haining Hu, Haiyan Xu, Huanan Liu, Xiaoping Pi
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Publication number: 20190147299Abstract: A data processing method for a convolutional neural network includes: (a) obtaining a matrix parameter of an eigenmatrix; (b) reading corresponding data in an image data matrix from a first buffer space based on the matrix parameter through a first bus, to obtain a next to-be-expanded data matrix, and sending and storing the to-be-expanded data matrix to a second preset buffer space through a second bus; (c) reading the to-be-expanded data matrix, and performing data expansion on the to-be-expanded data matrix to obtain expanded data; (d) reading a preset number of pieces of unexpanded data in the image data matrix, sending and storing the unexpanded data to the second preset buffer space, and updating, based on the unexpanded data, the to-be-expanded data matrix; and (e). repeating (c) and (d) until all data in the image data matrix is completely read out on the to-be-expanded data matrix.Type: ApplicationFiled: January 17, 2019Publication date: May 16, 2019Inventors: Yangming ZHANG, Jianlin GAO, Heng ZHANG
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Patent number: 10278962Abstract: The present invention relates to a series of analogs of natural product Pyripyropene A represented by general formula I and a preparation method and use thereof. More particularly, the present invention relates to analogs of the natural product Pyripyropene A, a preparation method and use thereof as the acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors for the treatment of cardiovascular diseases such as atherosclerosis and the like.Type: GrantFiled: March 3, 2016Date of Patent: May 7, 2019Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCESInventors: Fajun Nan, Boliang Li, Yang Zhan, Xiaowei Zhang, Ying Xiong, Xichan Hu, Yangming Zhang
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Patent number: 10077245Abstract: The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.Type: GrantFiled: April 22, 2015Date of Patent: September 18, 2018Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCESInventors: Fajun Nan, Min Li, Zhaobing Gao, Yangming Zhang, Haining Hu, Haiyan Xu, Huanan Liu, Xiaoping Pi
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Publication number: 20180134677Abstract: The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.Type: ApplicationFiled: January 12, 2018Publication date: May 17, 2018Inventors: Fajun Nan, Min Li, Zhaobing Gao, Yangming Zhang, Haining Hu, Haiyan Xu, Huanan Liu, Xiaoping Pi
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Publication number: 20180064696Abstract: The present invention relates to a series of analogues of natural product Pyripyropene A represented by general formula I and a preparation method and use thereof. More particularly, the present invention relates to analogues of the natural product Pyripyropene A, a preparation method and use thereof as the acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors for the treatment of cardiovascular diseases such as atherosclerosis and the like.Type: ApplicationFiled: March 3, 2016Publication date: March 8, 2018Inventors: Fajun NAN, Boliang LI, Yang ZHAN, Xiaowei ZHANG, Ying XIONG, Xichan HU, Yangming ZHANG
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Patent number: 9643941Abstract: The present invention relates to a thiazole-based compound, a preparation method therefor, and a use thereof. More specifically, the present invention relates to a 2,2?-bis-thiazole-based compound, a preparation method therefor, and a use of 2,2?-bis-thiazole-based compound a histone deacetylase inhibitor in the preparation of an antitumor medicament, a medicament for treating autoimmune diseases, a medicament for treating type II diabetes mellitus and complication thereof, or a medicament for treating neurodegenerative diseases.Type: GrantFiled: March 27, 2015Date of Patent: May 9, 2017Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCESInventors: Fajun Nan, Jia Li, Xin Xie, Chaojun Gong, Yubo Zhou, Hui Chai, Yangming Zhang, Mingbo Su
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Publication number: 20170081301Abstract: The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.Type: ApplicationFiled: April 22, 2015Publication date: March 23, 2017Inventors: Fajun NAN, Min LI, Zhaobing GAO, Yangming ZHANG, Haining HU, Haiyan XU, Huanan LIU, Xiaoping PI
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Publication number: 20170044119Abstract: The present invention relates to a thiazole-based compound, a preparation method therefor, and a use thereof. More specifically, the present invention relates to a 2,2?-bis-thiazole-based compound, a preparation method therefor, and a use of 2,2?-bis-thiazole-based compound a histone deacetylase inhibitor in the preparation of an antitumor medicament, a medicament for treating autoimmune diseases, a medicament for treating type II diabetes mellitus and complication thereof, or a medicament for treating neurodegenerative diseases.Type: ApplicationFiled: March 27, 2015Publication date: February 16, 2017Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCESInventors: Fajun NAN, Jia LI, Xin XIE, Chaojun GONG, Yubo ZHOU, Hui CHAI, Yangming ZHANG, Mingbo SU
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Patent number: 9353048Abstract: The present invention provides compounds having the structure represented by general formula I, pharmaceutically acceptable salts thereofagonist, preparation methods therefor and a use thereof in the preparation of a medicine for the treatment of nervous system diseases. The compounds or pharmaceutical compositions thereof can be used as the KCNQ potassium channel agonist for treating nervous system diseases. Compared to retigabine, a compound in the prior art, the compound of the present invention have the same or better therapeutic effect, are easier for synthesis and storage, and less prone to oxidate deterioration.Type: GrantFiled: October 23, 2012Date of Patent: May 31, 2016Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCESInventors: Fajun Nan, Min Li, Zhaobing Gao, Fei Chen, Yangming Zhang, Pingzheng Zhou, Haining Hu, Haiyan Xu, Sheng Liu