Patents by Inventor Yangming Zhang

Yangming Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240351966
    Abstract: Provided are a class of alkylphenol compounds and a preparation method therefor. Specifically provided are a new alkyl polyphenol compound as represented by chemical formula I, and a preparation method therefor and the use thereof in the treatment of metabolic syndrome.
    Type: Application
    Filed: May 11, 2022
    Publication date: October 24, 2024
    Inventors: Fajun NAN, Jingya LI, Zheng ZHANG, Yanan DUAN, Yangming ZHANG, Dandan CHEN, Chengqiu DAI
  • Patent number: 11593594
    Abstract: A data processing method for a convolutional neural network includes: (a) obtaining a matrix parameter of an eigenmatrix; (b) reading corresponding data in an image data matrix from a first buffer space based on the matrix parameter through a first bus, to obtain a next to-be-expanded data matrix, and sending and storing the to-be-expanded data matrix to a second preset buffer space through a second bus; (c) reading the to-be-expanded data matrix, and performing data expansion on the to-be-expanded data matrix to obtain expanded data; (d) reading a preset number of pieces of unexpanded data in the image data matrix, sending and storing the unexpanded data to the second preset buffer space, and updating, based on the unexpanded data, the to-be-expanded data matrix; and (e). repeating (c) and (d) until all data in the image data matrix is completely read out on the to-be-expanded data matrix.
    Type: Grant
    Filed: November 9, 2021
    Date of Patent: February 28, 2023
    Assignee: TENCENT TECHNOLOGY (SHENZHEN) COMPANY LIMITED
    Inventors: Yangming Zhang, Jianlin Gao, Heng Zhang
  • Patent number: 11449576
    Abstract: Embodiments of this application provide a convolution operation processing method and a related product. The integrated chip includes a control unit, at least one convolutional processing element, an input cache, and an output cache. The control unit loads a sectioned convolution kernel and sectioned convolution input data into the input cache, the sectioned convolution kernel being generated by sectioning a convolution kernel and including a plurality of convolution kernel segments, and the sectioned convolution input data being generated by sectioning convolution input data and including a plurality of convolution input data segments; and the at least one convolutional processing element performs a sectioned convolution operation on the sectioned convolution kernel and the sectioned convolution input data to obtain a sectioned convolution result, and stores the sectioned convolution result into the output cache.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: September 20, 2022
    Assignee: Tencent Technology (Shenzhen) Company Limited
    Inventors: Heng Zhang, Yangming Zhang
  • Publication number: 20220067447
    Abstract: A data processing method for a convolutional neural network includes: (a) obtaining a matrix parameter of an eigenmatrix; (b) reading corresponding data in an image data matrix from a first buffer space based on the matrix parameter through a first bus, to obtain a next to-be-expanded data matrix, and sending and storing the to-be-expanded data matrix to a second preset buffer space through a second bus; (c) reading the to-be-expanded data matrix, and performing data expansion on the to-be-expanded data matrix to obtain expanded data; (d) reading a preset number of pieces of unexpanded data in the image data matrix, sending and storing the unexpanded data to the second preset buffer space, and updating, based on the unexpanded data, the to-be-expanded data matrix; and (e). repeating (c) and (d) until all data in the image data matrix is completely read out on the to-be-expanded data matrix.
    Type: Application
    Filed: November 9, 2021
    Publication date: March 3, 2022
    Inventors: Yangming ZHANG, Jianlin GAO, Heng ZHANG
  • Patent number: 11222240
    Abstract: A data processing method for a convolutional neural network includes: (a) obtaining a matrix parameter of an eigenmatrix; (b) reading corresponding data in an image data matrix from a first buffer space based on the matrix parameter through a first bus, to obtain a next to-be-expanded data matrix, and sending and storing the to-be-expanded data matrix to a second preset buffer space through a second bus; (c) reading the to-be-expanded data matrix, and performing data expansion on the to-be-expanded data matrix to obtain expanded data; (d) reading a preset number of pieces of unexpanded data in the image data matrix, sending and storing the unexpanded data to the second preset buffer space, and updating, based on the unexpanded data, the to-be-expanded data matrix; and (e). repeating (c) and (d) until all data in the image data matrix is completely read out on the to-be-expanded data matrix.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: January 11, 2022
    Assignee: TENCENT TECHNOLOGY (SHENZHEN) COMPANY LIMITED
    Inventors: Yangming Zhang, Jianlin Gao, Heng Zhang
  • Patent number: 11192916
    Abstract: Disclosed are a pentacyclic triterpene compound as shown in general formula (I) and a preparation method therefor. The compound has an effective antagonistic effect on FXR receptors.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: December 7, 2021
    Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Fajun Nan, Xin Xie, Chenlu Zhang, Shimeng Guo, Yangming Zhang, Siwei Wang
  • Patent number: 10766889
    Abstract: The invention describes an aryl-2,2?-tandem bisthiazole compound and a preparation method and the use thereof. In particular, disclosed in the present invention are an aryl-2,2?-tandem bisthiazole compound with the structure as shown in general formula I and the preparation method thereof and use thereof as a histone deacetylase inhibitor in the preparation of antitumor drugs.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: September 8, 2020
    Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Fajun Nan, Jia Li, Jian Ding, Meiyu Geng, Yangming Zhang, Yi Chen, Yubo Zhou, Chaojun Gong, Mingbo Su, Anhui Gao
  • Publication number: 20200231623
    Abstract: Disclosed are a pentacyclic triterpene compound as shown in general formula (I) and a preparation method therefor. The compound has an effective antagonistic effect on FXR receptors.
    Type: Application
    Filed: September 17, 2018
    Publication date: July 23, 2020
    Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Fajun NAN, Xin XIE, Chenlu ZHANG, Shimeng GUO, Yangming ZHANG, Siwei WANG
  • Publication number: 20200074288
    Abstract: Embodiments of this application provide a convolution operation processing method and a related product. The integrated chip includes a control unit, at least one convolutional processing element, an input cache, and an output cache. The control unit loads a sectioned convolution kernel and sectioned convolution input data into the input cache, the sectioned convolution kernel being generated by sectioning a convolution kernel and including a plurality of convolution kernel segments, and the sectioned convolution input data being generated by sectioning convolution input data and including a plurality of convolution input data segments; and the at least one convolutional processing element performs a sectioned convolution operation on the sectioned convolution kernel and the sectioned convolution input data to obtain a sectioned convolution result, and stores the sectioned convolution result into the output cache.
    Type: Application
    Filed: November 8, 2019
    Publication date: March 5, 2020
    Applicant: Tencent Technology (Shenzhen) Company Limited
    Inventors: Heng ZHANG, Yangming ZHANG
  • Publication number: 20190211005
    Abstract: The invention describes an aryl-2,2?-tandem bisthiazole compound and a preparation method and the use thereof. In particular, disclosed in the present invention are an aryl-2,2?-tandem bisthiazole compound with the structure as shown in general formula I and the preparation method thereof and use thereof as a histone deacetylase inhibitor in the preparation of antitumor drugs.
    Type: Application
    Filed: August 24, 2017
    Publication date: July 11, 2019
    Inventors: Fajun NAN, Jia LI, Jian DING, Meiyu GENG, Yangming ZHANG, Yi CHEN, Yubo ZHOU, Chaojun GONG, Mingbo SU, Anhui GAO
  • Patent number: 10316008
    Abstract: The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: June 11, 2019
    Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Fajun Nan, Min Li, Zhaobing Gao, Yangming Zhang, Haining Hu, Haiyan Xu, Huanan Liu, Xiaoping Pi
  • Publication number: 20190147299
    Abstract: A data processing method for a convolutional neural network includes: (a) obtaining a matrix parameter of an eigenmatrix; (b) reading corresponding data in an image data matrix from a first buffer space based on the matrix parameter through a first bus, to obtain a next to-be-expanded data matrix, and sending and storing the to-be-expanded data matrix to a second preset buffer space through a second bus; (c) reading the to-be-expanded data matrix, and performing data expansion on the to-be-expanded data matrix to obtain expanded data; (d) reading a preset number of pieces of unexpanded data in the image data matrix, sending and storing the unexpanded data to the second preset buffer space, and updating, based on the unexpanded data, the to-be-expanded data matrix; and (e). repeating (c) and (d) until all data in the image data matrix is completely read out on the to-be-expanded data matrix.
    Type: Application
    Filed: January 17, 2019
    Publication date: May 16, 2019
    Inventors: Yangming ZHANG, Jianlin GAO, Heng ZHANG
  • Patent number: 10278962
    Abstract: The present invention relates to a series of analogs of natural product Pyripyropene A represented by general formula I and a preparation method and use thereof. More particularly, the present invention relates to analogs of the natural product Pyripyropene A, a preparation method and use thereof as the acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors for the treatment of cardiovascular diseases such as atherosclerosis and the like.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: May 7, 2019
    Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Fajun Nan, Boliang Li, Yang Zhan, Xiaowei Zhang, Ying Xiong, Xichan Hu, Yangming Zhang
  • Patent number: 10077245
    Abstract: The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: September 18, 2018
    Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Fajun Nan, Min Li, Zhaobing Gao, Yangming Zhang, Haining Hu, Haiyan Xu, Huanan Liu, Xiaoping Pi
  • Publication number: 20180134677
    Abstract: The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.
    Type: Application
    Filed: January 12, 2018
    Publication date: May 17, 2018
    Inventors: Fajun Nan, Min Li, Zhaobing Gao, Yangming Zhang, Haining Hu, Haiyan Xu, Huanan Liu, Xiaoping Pi
  • Publication number: 20180064696
    Abstract: The present invention relates to a series of analogues of natural product Pyripyropene A represented by general formula I and a preparation method and use thereof. More particularly, the present invention relates to analogues of the natural product Pyripyropene A, a preparation method and use thereof as the acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors for the treatment of cardiovascular diseases such as atherosclerosis and the like.
    Type: Application
    Filed: March 3, 2016
    Publication date: March 8, 2018
    Inventors: Fajun NAN, Boliang LI, Yang ZHAN, Xiaowei ZHANG, Ying XIONG, Xichan HU, Yangming ZHANG
  • Patent number: 9643941
    Abstract: The present invention relates to a thiazole-based compound, a preparation method therefor, and a use thereof. More specifically, the present invention relates to a 2,2?-bis-thiazole-based compound, a preparation method therefor, and a use of 2,2?-bis-thiazole-based compound a histone deacetylase inhibitor in the preparation of an antitumor medicament, a medicament for treating autoimmune diseases, a medicament for treating type II diabetes mellitus and complication thereof, or a medicament for treating neurodegenerative diseases.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: May 9, 2017
    Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Fajun Nan, Jia Li, Xin Xie, Chaojun Gong, Yubo Zhou, Hui Chai, Yangming Zhang, Mingbo Su
  • Publication number: 20170081301
    Abstract: The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.
    Type: Application
    Filed: April 22, 2015
    Publication date: March 23, 2017
    Inventors: Fajun NAN, Min LI, Zhaobing GAO, Yangming ZHANG, Haining HU, Haiyan XU, Huanan LIU, Xiaoping PI
  • Publication number: 20170044119
    Abstract: The present invention relates to a thiazole-based compound, a preparation method therefor, and a use thereof. More specifically, the present invention relates to a 2,2?-bis-thiazole-based compound, a preparation method therefor, and a use of 2,2?-bis-thiazole-based compound a histone deacetylase inhibitor in the preparation of an antitumor medicament, a medicament for treating autoimmune diseases, a medicament for treating type II diabetes mellitus and complication thereof, or a medicament for treating neurodegenerative diseases.
    Type: Application
    Filed: March 27, 2015
    Publication date: February 16, 2017
    Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Fajun NAN, Jia LI, Xin XIE, Chaojun GONG, Yubo ZHOU, Hui CHAI, Yangming ZHANG, Mingbo SU
  • Patent number: 9353048
    Abstract: The present invention provides compounds having the structure represented by general formula I, pharmaceutically acceptable salts thereofagonist, preparation methods therefor and a use thereof in the preparation of a medicine for the treatment of nervous system diseases. The compounds or pharmaceutical compositions thereof can be used as the KCNQ potassium channel agonist for treating nervous system diseases. Compared to retigabine, a compound in the prior art, the compound of the present invention have the same or better therapeutic effect, are easier for synthesis and storage, and less prone to oxidate deterioration.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: May 31, 2016
    Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Fajun Nan, Min Li, Zhaobing Gao, Fei Chen, Yangming Zhang, Pingzheng Zhou, Haining Hu, Haiyan Xu, Sheng Liu