Abstract: The invention provides a 7-ethyl-10-hydroxycamptothecin drug precursor with fluorescence activity and a preparation method and use thereof. The method involves that a carboxyl group of a boron dipyrromethene dye molecule is condensed with a hydroxyl group at the 10 position of 7-ethyl-10-hydroxycamptothecin, yielding a 7-ethyl-10-hydroxy-camptothecin drug precursor (BDP-SN38) with fluorescent activity. BDP-SN38 shows good solubility and stability in most pharmaceutically acceptable solvents. Compared with SN38, BDP-SN38 exhibits comparable antitumor activity, has high tumor uptake capacity, and produces strong green fluorescence with the excitation of visible light, thus providing fluorescence-guided bioimaging and further treatment of residual tumors after drug treatment, and having good application prospects in the research of integrated diagnosis and treatment and effective tumor treatment.

Abstract: A programmable metasurface and method is described having a plurality of parallel slits in an elastic substrate plate defining a plurality of unit cells, each having an actuator beam and a sensing beam with a slit therebetween. Each sensing beam has a pair of sensors for sensing flexural waves in the substrate. The actuator beam has a piezoelectric actuator that is controlled by a control circuit where the control circuit generates an actuator signal and where the control circuit compares the preceding actuator signal to the difference between the sensors and an electrical transfer function to result in the metasurface being able to perform a desired function.

Abstract: The present invention relates to the technical field of photosensitizers, and particularly to a near-infrared nano-photosensitizer and a preparation method and use thereof. The near-infrared nano-photosensitizer in the present invention is modified by conjugation extension of the boron dipyrromethene core, achieving absorption and emission spectra close to the near-infrared region. A polyfluoroalkyl group and a polyethylene glycol group are introduced to the boron dipyrromethene structure to obtain an amphiphilic photosensitizer. By means of the strong fluorine-fluorine interaction between the polyfluoroalkyl group and the hydrophilic interaction of the polyethylene glycol group, a nano-photosensitive micelle with an ultra-low CMC value is ultimately constructed. Boron dipyrromethene is induced by fluorine-fluorine interaction to undergo J-aggregation, causing the maximum absorption peak to red-shift to the near-infrared region, beneficial to the deep phototherapy of tumors.

Abstract: Methods and systems are provided for ranking search results and generating a presentation. In some implementations, a search system generates a presentation based on a search query. In some implementations, a search system ranks search results based on data stored in a knowledge graph. In some implementations, a search system identifies a modifying concept such as a superlative in a received search query, and determines ranking properties based on the modifying concept.

Abstract: A powered device interface assembly includes an optocoupler and a powered device interface. The opto-coupler is electrically coupled with a microcontroller of the power device interface. The powered device interface includes a telemetry circuit coupled with the opto-coupler and configured to generate encoded telemetry information for output via a single pin of the powered device interface for transmission to the microcontroller of the powered device, wherein the opto-coupler is coupled with the single pin and is configured to electrically isolate the single pin from the microcontroller.

Abstract: The present invention discloses a capsaicin-derived photosensitizer, and a preparation method and use thereof. Boron-dipyrromethene is used as a core of the photosensitizer, which has a maximum absorption peak red-shifted to the near infrared region by expanding the ? system and is introduced with a capsaicin-targeting group to construct a capsaicin-derived photosensitizer cap-BDP with high-performance targeting of TRPV1 protein. The photosensitizer can generate singlet oxygen under low-power LED irradiation, which specifically activates the TRPV1 protein pathway, causes significant calcium influx, and induces apoptosis of tumor cells. Moreover, the generated singlet oxygen directly oxidizes endogenous substances in cells to cause cell apoptosis, eventually achieving light-induced bifunctional synergistic therapy.

Abstract: The present invention relates to the technical field of photosensitizers, and particularly to a near-infrared nano-photosensitizer and a preparation method and use thereof. The near-infrared nano-photosensitizer in the present invention is modified by conjugation extension of the boron dipyrromethene core, achieving absorption and emission spectra close to the near-infrared region. A polyfluoroalkyl group and a polyethylene glycol group are introduced to the boron dipyrromethene structure to obtain an amphiphilic photosensitizer. By means of the strong fluorine-fluorine interaction between the polyfluoroalkyl group and the hydrophilic interaction of the polyethylene glycol group, a nano-photosensitive micelle with an ultra-low CMC value is ultimately constructed. Boron dipyrromethene is induced by fluorine-fluorine interaction to undergo J-aggregation, causing the maximum absorption peak to red-shift to the near-infrared region, beneficial to the deep phototherapy of tumors.

Abstract: The present disclosure relates a fake head assembly including a fake head body having an engage face, a first vacuum suction hole configured to be connected to an evacuating device to perform an evacuation, an adsorption portion having an adsorption surface, a plurality of first vacuum holes inside the fake head body, each first vacuum hole including a first end on the adsorption surface and a second end on the engage face, the plurality of first vacuum holes being arranged in order in a first direction of the fake head assembly; a shunt device detachably connected to the fake head body, the shunt device having a plurality of evacuating slots which extend in the first direction and have different extension lengths; the first vacuum suction hole being closable by the shunt device and selectively communicated with one evacuating slot, so as to be communicated the second end of at least some of the first vacuum holes via the one evacuating slot; and a connecting device for connecting the shunt device to the enga

Abstract: The present disclosure relates a fake head assembly including a fake head body having an engage face, a first vacuum suction hole configured to be connected to an evacuating device to perform an evacuation, an adsorption portion having an adsorption surface, a plurality of first vacuum holes inside the fake head body, each first vacuum hole including a first end on the adsorption surface and a second end on the engage face, the plurality of first vacuum holes being arranged in order in a first direction of the fake head assembly; a shunt device detachably connected to the fake head body, the shunt device having a plurality of evacuating slots which extend in the first direction and have different extension lengths; the first vacuum suction hole being closable by the shunt device and selectively communicated with one evacuating slot, so as to be communicated the second end of at least some of the first vacuum holes via the one evacuating slot; and a connecting device for connecting the shunt device to the enga