Abstract: An isolated antigen-binding protein, having one or more of the following properties: 1) capable of binding to human and monkey-derived GITR proteins at a KD value of 7×10?12 or below, wherein the KD value is measured by BLI method; 2) capable of stimulating immune cell proliferation; 3) capable of stimulating immune cells to secrete IFN-?, wherein the secretion is measured in T cell viability assay; 4) capable of inhibiting tumor growth and/or tumor cell proliferation; 5) capable of activating GITR signaling pathway; 6) capable of inhibiting the binding of GITR to GITRL.

Abstract: Provided is a Beta molecular sieve having multi-level channels and synthesis method thereof. The molecular sieve has a two-level mesoporous structure and uses polyquaternium-6, polyquaternium-7, polyquaternium-22, or polyquaternium-39 as a guiding agent for both micropores and mesopores during the process of synthesis. The present invention uses cheap raw materials and a simple synthesis method, and has broad industrial application prospect.