Patents by Inventor Yangzhe Gao

Yangzhe Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for biocatalytic synthesis of Sitagliptin and intermediate thereof
    Patent number: 11459549
    Abstract: Provided is a method for biocatalytic synthesis of Sitagliptin and intermediates thereof, in particular, provided are compounds of Formula (I) and Formula (II), or pharmaceutically acceptable salts thereof, a polypeptide capable of catalyzing conversion of a compound of Formula (I) to a compound of Formula (II), a nucleic acid encoding the polypeptide, a vector and a cell comprising the nucleic acid. In addition, also provided are a method for producing a compound of Formula (II) and Sitagliptin by using the polypeptide and the compound of Formula (I), and a method for preparing the polypeptide.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: October 4, 2022
    Assignees: China Fortune Way Company, Nanjing Redwood Fine Chemical Co., Ltd.
    Inventors: Fahao Wu, Wen Yang, Gang Li, Hongwei Shi, Yangzhe Gao, Lili Liu, Zhifa Yuan
  • METHOD FOR BIOCATALYTIC SYNTHESIS OF SITAGLIPTIN AND INTERMEDIATE THEREOF
    Publication number: 20210123080
    Abstract: Provided is a method for biocatalytic synthesis of Sitagliptin and intermediates thereof, in particular, provided are compounds of Formula (I) and Formula (II), or pharmaceutically acceptable salts thereof, a polypeptide capable of catalyzing conversion of a compound of Formula (I) to a compound of Formula (II), a nucleic acid encoding the polypeptide, a vector and a cell comprising the nucleic acid. In addition, also provided are a method for producing a compound of Formula (II) and Sitagliptin by using the polypeptide and the compound of Formula (I), and a method for preparing the polypeptide.
    Type: Application
    Filed: July 27, 2018
    Publication date: April 29, 2021
    Applicants: China Fortune Way Company, Nanjing Redwood Fine Chemical Co., Ltd
    Inventors: Fahao Wu, Wen Yang, Gang Li, Hongwei Shi, Yangzhe Gao, Lili Liu, Zhifa Yuan