Abstract: Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, e.g., treating hyperphenylalaninemia, including phenylketonuria, and other disorders, including cancer.

Abstract: The present invention provides process for enriching adeno-associated virus particles using anion exchange chromatography and zonal ultracentrifugation.

Abstract: A semiconductor structure includes a substrate, a first electrode plate over the substrate, a second electrode plate over the first electrode plate, and a sidewall structure. The sidewall structure is attached to a side of the second electrode plate. A dielectric constant of the sidewall structure decreases in a direction away from the second electrode plate.

Abstract: The present invention provides use of substance A in the preparation of a medicament. The substance A is a naphthylurea compound as shown in formula I, a pharmaceutically acceptable salt thereof, a solvate thereof, a solvate of the pharmaceutically acceptable salt thereof, a crystal form thereof or a tautomer thereof, and the medicament is a medicament for treating a corneal neovascular disease. The naphthylurea compound of the present invention can treat the corneal neovascular disease by means of eye dropping administration.

Abstract: The present disclosure provides a semiconductor structure and a manufacturing method thereof. The manufacturing method of a semiconductor structure includes providing a substrate having trenches, regions other than the trenches in the substrate form a plurality of active regions at intervals; forming a first isolation layer and a second isolation layer, a top surface of the first isolation layer is lower than a top surface of the second isolation layer, a groove is formed between the second isolation layer and the active region; forming a barrier layer in the groove, an etching rate of the barrier layer is lower than an etching rate of the first isolation layer; and forming a third isolation layer in an intermediate trench, the intermediate trench is filled with the third isolation layer, and the first isolation layer, the second isolation layer, the third isolation layer, and the barrier layer form an isolation structure.

Abstract: Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, e.g., treating hyperphenylalaninemia, including phenylketonuria, and other disorders, including cancer.

Abstract: A polyvinylidene fluoride (PVDF) casting membrane solution is shaped as a flat sheet membrane by thermally induced phase separation (TIPS), the PVDF membrane is defluorinated with an alkaline potassium permanganate solution, and then the carbon chain is extended with glycidyl methacrylate (GMA) as the graft monomer, and finally the nucleophilic substitution is carried out between melamine and GMA to produce a chelating microfiltration membrane for capturing and enriching heavy metals with high flux and high capacity.

Abstract: A method and a device for synchronous high-speed photographing of microparticle rotation in a liquid cyclone field and for determining the rotation velocity of a microparticle in a liquid cyclone field by using a combination of a synchronous high-speed photographing system and a transparent microparticle containing two centrosymmetrically arranged inner cores having the same diameter. The method comprises: using a transparent microparticle comprising two inner cores having the same diameter and arranged centrosymmetrically as a rotation test particle; acquiring synchronously two groups of two dimensional image series of microparticle motion in a liquid cyclone field using two orthogonally arranged high-speed digital cameras; and reconstructing a three dimensional motion trajectory of the microparticle from the two groups of synchronous image series, and determining a rotation velocity of the microparticle in the cyclone field at the same time.

Abstract: Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, e.g., treating hyperphenylalaninemia, including phenylketonuria, and other disorders, including cancer.

Abstract: The present invention discloses a breeding method for obtaining heterosis in lined seahorses, which comprises the following steps: S1, selecting parents of lined seahorse from populations with great differences in genetic background; S2, intensified rearing the parents before pregnancy; S3, matching and breeding the parents of lined seahorse from different geographical populations according to complete diallel cross method; S4, finely nursing pregnant seahorses; S5, respectively collecting all postlarvae (filial generations) hatched by each breeding group in one week; S6, rearing the filial generations; and S7, comparing survival rate and growth performance of filial generations. The present invention, via hybridization of different geographical populations to obtain lined seahorse, makes effective use of heterosis. Survival rate and growth rate of filial generations are apparently enhanced compared to that of those filial generations without hybridization.

Abstract: Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, e.g., treating hyperphenylalaninemia, including phenylketonuria, and other disorders, including cancer.

Abstract: A polyvinylidene fluoride (PVDF) casting membrane solution is shaped as a flat sheet membrane by thermally induced phase separation (TIPS), the PVDF membrane is defluorinated with an alkaline potassium permanganate solution, and then the carbon chain is extended with glycidyl methacrylate (GMA) as the graft monomer, and finally the nucleophilic substitution is carried out between melamine and GMA to produce a chelating microfiltration membrane for capturing and enriching heavy metals with high flux and high capacity.

Abstract: A method and a device for synchronous high-speed photographing of microparticle rotation in a liquid cyclone field and for determining the rotation velocity of a microparticle in a liquid cyclone field by using a combination of a synchronous high-speed photographing system and a transparent microparticle containing two centrosymmetrically arranged inner cores having the same diameter. The method comprises: using a transparent microparticle comprising two inner cores having the same diameter and arranged centrosymmetrically as a rotation test particle; acquiring synchronously two groups of two dimensional image series of microparticle motion in a liquid cyclone field using two orthogonally arranged high-speed digital cameras; and reconstructing a three dimensional motion trajectory of the microparticle from the two groups of synchronous image series, and determining a rotation velocity of the microparticle in the cyclone field at the same time.

Abstract: The invention relates to a process and a device for treating a catalyst discharged from bubbling bed hydrogenation of residual oil. Provided is a process for treating a catalyst discharged from bubbling bed hydrogenation of residual oil, comprising the following steps: (1) adjustment and control to reduce viscosity; (2) desorption and separation by rotational flow; and (3) separation and resource utilization of an oil-water-catalyst three phase. Also provided is a device for treating a catalyst discharged from bubbling bed hydrogenation of residual oil.

Abstract: The present invention discloses a breeding method for obtaining heterosis in lined seahorses, which comprises the following steps: S1, selecting parents of lined seahorse from populations with great differences in genetic background; S2, intensified rearing the parents before pregnancy; S3, matching and breeding the parents of lined seahorse from different geographical populations according to complete diallel cross method; S4, finely nursing pregnant seahorses; S5, respectively collecting all postlarvae (filial generations) hatched by each breeding group in one week; S6, rearing the filial generations; and S7, comparing survival rate and growth performance of filial generations. The present invention, via hybridization of different geographical populations to obtain lined seahorse, makes effective use of heterosis. Survival rate and growth rate of filial generations are apparently enhanced compared to that of those filial generations without hybridization.

Abstract: An method for selective breeding of a fast-growing strain of lined seahorse, including: (1) selecting high-quality lined seahorse parents as a base population for selective breeding; (2) performing prenatal intensified breeding; (3) performing pairing and mating, and rearing the juveniles thereof; (4) performing selective breeding in three junctures with different selection proportions; (5) pairing the saved adult lined seahorses, wherein those with low vitality, having injuries on the body surface, or having a dysplastic brood pouch or gonad are culled, and a selection proportion of 10% for every generation is maintained thereafter; (6) repeating steps (2) through (5) for at least four times to obtain a high-quality strain of lined seahorse with improved weight and body length and stable growth. The method can be used for selective breeding of a new strain with high quality and high yield.

Abstract: Provided are a method and an apparatus for micro-hydrocyclone purification for a flue gas carbon dioxide capture system. The method comprises: performing gas-liquid micro-hydrocylone separation with ultralow pressure drop on scrubbed flue gas, to remove aerosol particulates entrained in the flue gas; performing gas-liquid micro hydrocyclone separation with ultralow pressure drop on off-gas vented from the top of an absorption column, to remove entrained aerosol particulates; performing gas-liquid micro hydrocyclone separation with ultralow pressure drop on cooled regeneration gas, to remove entrained aerosol particulates; and performing liquid-solid and liquid-liquid two-stage micro-hydrocyclone separation on a mixed amine solution lean for carbon dioxide discharged from regeneration column, to remove entrained solid particulates and machine oil.

Abstract: Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, e.g., treating hyperphenylalaninemia, including phenylketonuria, and other disorders, including cancer.

Abstract: The present invention relates to naphthylurea derivatives. Such substances can significantly inhibit VEGFR2 and PDGFR-? receptor tyrosine kinase phosphorylation at nanomolar concentration levels. It is a novel type of tyrosine kinase inhibitors which can be used in the treatment of tyrosine kinase-mediated diseases or symptoms such as malignancies and ocular diseases accompanied with pathologic neovascularization.

Abstract: The present invention relates to naphthylurea derivatives. Such substances can significantly inhibit VEGFR2 and PDGFR-? receptor tyrosine kinase phosphorylation at nanomolar concentration levels.