Abstract: A method for inducing differentiated cells into mesenchymal stem cells (MSCs), and combinations of regulatory targets thereof. The method includes performing a directional induction on the differentiated cells to prepare the mesenchymal stem cells. The directional induction includes treating cells by inhibiting the TGF-? signal pathway, inhibiting the activity of PKC, activating the WNT/?-catenin signal pathway and activating the cAMP signal pathway. By regulating corresponding signal pathways and/or enzymatic activities by stages, the differentiated cells are induced into the mesenchymal stem cells.

Abstract: An intelligent control method for a dry dense medium fluidized bed separator includes supplying air to fluidize a bed; estimating an initial bed density according to a washability curve of a raw coal; detecting a magnetic material content in the bed to obtain a real-time bed density, and adjusting the real-time bed density according to a result from an analysis on a deviation from the initial bed density; during separation, adjusting a medium addition amount and a scraper discharge speed to maintain a stability of a bed height; separating the raw coal in the dry dense medium fluidized bed separator to obtain a clean coal product; and detecting a product ash content of the clean coal product, comparing the product ash content with a target ash content, and if a difference between the product ash content and the target ash content exceeds an expectation, adjusting the initial bed density.

Abstract: A preparation method and applications of rejuvenated and regenerative fibroblasts, where the rejuvenated and regenerative fibroblasts are prepared from normal fibroblasts by inhibiting the JAK-STAT signaling pathway. The rejuvenated and regenerative fibroblasts are prepared by treating the target cells with a small molecular combination, a cytokine combination or a recombinant protein combination. This application further provides an application of the rejuvenated and regenerative fibroblasts in the reprogramming or rejuvenation of cells, tissues, organs and organisms.

Abstract: A method of regulating differentiation, dedifferentiation, transdifferentiation, rejuvenation, aging and apoptosis of target cells and uses thereof In the method, a gene or protein target involved in the JAK-STAT signaling pathway is regulated quantitatively or in a timing manner using a small molecular combination, a cytokine or recombinant protein combination, gene editing or transgenic technique to achieve the rejuvenation and/or obtain different lineages of cells. This application further provides applications of cell products generated in the method or their derivatives in the reprogramming and immunoregulation of cells, tissues, organs and organisms, construction of tissue engineering materials, repairing of injured, aged and degenerated mammalian tissues and organs and delaying and reversing of the aging process of cells, tissues, organs and organisms.

Abstract: A method for inducing differentiated cells into mesenchymal stem cells (MSCs), and combinations of regulatory targets thereof. The method includes performing a directional induction on the differentiated cells to prepare the mesenchymal stem cells. The directional induction includes treating cells by inhibiting the TGF-? signal pathway, inhibiting the activity of PKC, activating the WNT/?-catenin signal pathway and activating the cAMP signal pathway. By regulating corresponding signal pathways and/or enzymatic activities by stages, the differentiated cells are induced into the mesenchymal stem cells.