Abstract: Provided is a molecule comprising an Fc variant. Compared with a molecule comprising an IgG wild-type Fc, the molecule is resistant to the degradation of an immunoglobulin enzyme, and the molecule comprises a human IgG Fc region having a mutation, the mutation being one or more substitutions or deletions at a G237 position (EU numbering), and the substitution preferably being G237A. Further provided are a nucleic acid encoding the molecule, a vector comprising the nucleic acid and a host cell, and a method for preparing the molecule.

Abstract: An antibiotic pharmaceutical composition for intradermal or subcutaneous administration is provided, which includes an antibiotic and hyaluronidase (HAase). In the antibiotic pharmaceutical composition, a content of the antibiotic is 10 mg/mL-5 g/Ml, and a content of the HAase is 45 units/ml-4500000 units/ml. A kit is provided, which includes the pharmaceutical composition. A method for preparing the kit, and use of the pharmaceutical composition are further provided.

Abstract: The present disclosure provides a pharmaceutical composition or drug kit for alleviating or treating fibrotic diseases, and a use thereof. Disclosed is a novel medication regimen in which a platelet endothelial aggregation receptor 1 (PEAR1) agonist and pirfenidone or nintedanib are used in combination.

Abstract: An information management method, a device, and a medium. The information management method applied to a first terminal, including: sending an information acquisition request to a server, so that the server responds to the information acquisition request and sends visitor information to the first terminal; receiving the visitor information sent by the server; generating card information according to the visitor information; and sending the card information to an electronic card, so that the electronic card displays the card information.

Abstract: The present invention provides a high-strength and high-plasticity titanium matrix composite and a preparation method thereof. The preparation method includes: preparing high-oxygen hydride-dehydride titanium powder using a high-temperature rotary ball grinding treatment process, in which the prepared hydride-dehydride titanium powder has a particle size of 10-40 ?m, and has an oxygen content of 0.8-1.5 wt. %; preparing high-purity ultra-fine oxygen adsorbent powder using a wet grinding method of high-energy vibration ball grinding treatment process; in which a purity of the oxygen adsorbent powder is ?99.9%, and a particle size of the oxygen adsorbent powder is ?8 ?m; mixing the high-oxygen hydride-dehydride titanium powder with the oxygen adsorbent powder in a protective atmosphere, and then press-forming the powder obtained after mixing to obtain a raw material blank; and performing atmosphere protective sintering treatment on the raw material blank to obtain a titanium matrix composite.

Abstract: Provided are a product and a method for treating thrombocytopenia. The product and the method can fundamentally solve the problem of thrombocytopenia from the perspective of an autoimmune mechanism.

Abstract: An Fc variant containing a 2,6-sialylated glycosylation modification is provided. The Fc variant has an increased affinity for human FcRn and an increased 2,6-sialylation level. The Fc variant can reduce the level of IgG in the blood, and 2,6-sialic acid thereof has an anti-inflammatory effect. A protein, composition or kit including the Fc variant is also provided.

Abstract: Disclosed is an invasion correction method and system for resistivity logging. The method includes the steps of: analyzing mud filtrate invasion features based on an actual resistivity logging curve; determining an invasion mechanism, and performing forward modeling on a resistivity logging response; performing inversion by a random forest method to form a correction chart; and outputting a formation resistivity to finally form the invasion correction method and system for resistivity logging. In the present disclosure, double lateral correction under an invasion condition is accomplished, while a chart method and an inversion method are combined, ensuring the accuracy and operating rate of correction.

Abstract: An information management method, a device, a system and a medium. The information management method applied to a first terminal, including: sending an information acquisition request to a server, so that the server responds to the information acquisition request and sends visitor information to the first terminal; receiving the visitor information sent by the server; generating card information according to the visitor information; and sending the card information to an electronic card, so that the electronic card displays the card information.

Abstract: A three-dimensional (3D) magnetic particle imaging (MPI) method and system without rotating a field-free line (FFL) are disclosed. In accordance with the method, an FFL is generated such that magnetic particles in a region far from the FFL enter a magnetic saturation state. Further, a non-uniform mixed-frequency excitation magnetic field parallel to the FFL is applied to generate intermodulation response signals. In addition, the intermodulation response signals are acquired, amplified and filtered. Moreover, the intermodulation response signals are transmitted to a digital signal processing unit and an image reconstruction unit, and an encoding matrix is constructed. Additionally, a one-dimensional (1D) concentration distribution of the magnetic particles is reconstructed based on the encoding matrix and an actually measured voltage signal. The FFL is driven for line-by-line scanning along a vertical plane of the FFL, thereby achieving 3D imaging.

Abstract: A technique serves information items associated with at least two item-serving modes using shared resources. For example, the technique delivers dynamic search ads in a dynamic search ad (DSA) mode using processing resources that were originally developed for serving text ads in a text ad (TA) mode. In a first aspect, the technique repurposes a part of the TA-mode processing flow to find a set of landing pages associated with a query. In a second aspect, the technique performs further processing based on output results generated by the TA-mode processing flow, with the objective of identifying a set of landing pages associated with the query. Overall, the technique reduces the consumption of resources in the serving of ads, and simplifies the maintenance of an ad-serving system. The technique also allows one mode to use algorithmic advances developed for use in another mode.

Abstract: A method includes: acquiring a plurality of historical routes of movement of a plurality of historical users in a geographic area, wherein each historical route includes at least a portion of a plurality of locations; determining, based on the plurality of historical routes and a plurality of current positions of a plurality of users in the geographic area, a set of predicted locations among the plurality of locations that the plurality of users will visit in the future, respectively, wherein the plurality of users use a tour guiding service associated with the plurality of locations that is provided by a mobile network; selecting a set of popular locations from the set of predicted locations based on the number of users among the plurality of users who will visit each predicted location in the set of predicted locations; and scheduling tour guiding resources associated with the set of popular locations.

Abstract: Provided are a mutant of an immunoglobulin degrading enzyme IdeE, a protein comprising the mutant, and a use of a composition and a kit in preparation of a drug for reducing the level of IgG in a subject. The mutant has amino acid substitution, N-terminal truncated and/or C-terminal truncated on one or more of positions 8, 10, 24, 59, 97, and 280 of the amino acid sequence shown in SEQ ID NO: 2, and the mutant has the function of the immunoglobulin degrading enzyme IdeE, and has higher activity and thermal stability than wild-type IdeE.

Abstract: Provided is a drug for preventing, alleviating or treating adhesion and a use thereof. A fibroblast which has been subjected to external stimulation in a body cavity contains an activated negative regulatory receptor PEAR1. The deletion of the fibroblast PEAR1 can significantly promote in vivo mucosal adhesion formation. A PEARI agonist can specifically inhibit fibroblast activation, synthesize an extracellular matrix, and ameliorate the adhesion lesion. By administering the PEARI agonist, the formation of adhesion can be effectively prevented. Also provided is a PEARI agonistic antibody that does not affect the repair and healing of normal tissue and does not cause the tissue to be in an anoxic state. Moreover, the antibody drug has a long half-life, is easily diffused, has few side effects, and has a convenient route of administration.

Abstract: Disclosed in the present invention is a method for treating or preventing a disease of incomplete immune reconstitution in aids using (5R)-5-hydroxytriptolide, in particular a method for treating or preventing a disease of incomplete immune reconstitution in AIDS in a subject in need thereof, comprising administering a therapeutically effective amount of a medicament comprising (5R)-5-hydroxytriptolide to the subject. The present invention uses (5R)-5-hydroxytriptolide (T8) in experiments and finds that (5R)-5-hydroxytriptolide has an immunosuppressive activity against incomplete immune reconstitution in AIDS, is characterized by high efficiency and low toxicity, and has a good safety treatment index.

Abstract: An information management method, a device, a system and a medium. The information management method applied to a first terminal, including: sending an information acquisition request to a server, so that the server responds to the information acquisition request and sends visitor information to the first terminal; receiving the visitor information sent by the server; generating card information according to the visitor information; and sending the card information to an electronic card, so that the electronic card displays the card information.

Abstract: An electromagnetic wave control apparatus includes an upper electrode layer, a lower electrode layer, a liquid crystal layer, and a first metamaterial layer disposed between the upper electrode layer and the lower electrode layer. The first metamaterial layer includes a first array including alignment unit structures. A first surface of the alignment unit structure is a surface that is of the alignment unit structure and that faces away from the liquid crystal layer. A length-to-width ratio of the first surface of the alignment unit structure is greater than 1. A length of the first surface, a width of the first surface, and a spacing between two adjacent alignment unit structures range from 1 nm to 5000 nm.

Abstract: Provided are a pharmaceutical combination and use thereof. The pharmaceutical combination is used for preparing a medicament for treating hyperglobulinemia, and comprises an immunoglobulin degradation enzyme and an Fc-containing protein. The pharmaceutical combination uses the immunoglobulin degradation enzyme and the Fc agents in combination in hyperglobulinemia, reduces the influence of globulin on treatment, enables the Fc agents to have better effects, and also reduces the clinical dose of some Fc agents. On one hand, side effects of a therapeutic agent can be reduced, and on the other hand, the economic burden of medication can also be reduced.

Abstract: Methods, apparatus, and processor-readable storage media for query processing based on a stochastic prediction model are provided herein. An example computer-implemented method includes maintaining information associated with a set of database operators corresponding to one or more historical query plans, wherein each of the historical query plans is associated with processing of a corresponding historical query in a database; building, based on the maintained information, a data structure comprising probabilities of each database operator in the set transitioning to each of one or more of the other database operators in the set; obtaining a new query to be processed in the database; applying a stochastic prediction algorithm to identify, from among the historical query plans, at least one candidate query plan for the new query based on the data structure; and executing the at least one candidate query plan to access data from the database for the new query.

Abstract: Provided is a mutant of an immunoglobulin degrading enzyme IdeE. The immunoglobulin degrading enzyme IdeE includes an amino acid sequence as shown in SEQ ID NO: 2 in the sequence listing. The mutant is obtained by means of replacing at least one or more of the positions 8, 10, 24, 59, 97, and 280 of the amino acid sequence. The function of the mutant includes at least the function of the immunoglobulin degrading enzyme IdeE. The activity and thermal stability of the provided mutant of the immunoglobulin degrading enzyme are higher than those of a wild-type IdeE.