Abstract: A pharmaceutical combination for subcutaneous administration and use thereof are provided. The pharmaceutical combination as described herein for subcutaneous administration includes a hyaluronidase and an antibody-drug conjugate. The antibody-drug conjugate includes a fragment of a bioactive molecule, and the bioactive molecule has moderate toxicity. The pharmaceutical combination can achieve a larger volume and a larger dose of administration, and the side reaction is not enhanced.

Abstract: Disclosed are a pyrazolone-fused pyrimidine compound, a preparation method for same and applications thereof. Provided in the present invention is the pyrazolone-fused pyrimidine compound as represented by formula (II). The compound has improved inhibitory activity with respect to WEE1 kinase.

Abstract: A cleaning robot and a carpet recognition method are provided. The cleaning robot includes a robot body and a control unit disposed in the robot body, wherein the cleaning robot further includes: a sleeve disposed at a front bottom of the robot body; and an ultrasonic sensor electrically connected to the control unit, wherein the ultrasonic sensor is fixed in the sleeve and configured to emit an ultrasonic wave signal to ground and receive an echo signal.

Abstract: A cleaning robot, comprising: a robot body, a control unit provided in the robot body, and a fixing unit provided at the bottom of a front end of the robot body, the fixing unit comprising a sleeve and an ultrasonic sensor, the ultrasonic sensor being fixed in the sleeve and being electrically connected to the control unit, and the ultrasonic sensor being used for emitting an ultrasonic wave downwards and receiving an echo reflected by different ground forms.

Abstract: A cleaning robot, comprising: a robot body, a control unit provided in the robot body, and a fixing unit provided at the bottom of a front end of the robot body, the fixing unit comprising a sleeve and an ultrasonic sensor, the ultrasonic sensor being fixed in the sleeve and being electrically connected to the control unit, and the ultrasonic sensor being used for emitting an ultrasonic wave downwards and receiving an echo reflected by different ground forms.

Abstract: A carpet recognition method for a robot cleaner and a robot cleaner are provided. The carpet recognition method is applied to a cleaning robot, the cleaning robot includes a sleeve and an ultrasonic sensor, and the recognition method includes: controlling the ultrasonic sensor to transmit an ultrasonic signal to a current ground and to receive an echo signal reflected by the current ground; recognizing the current ground as a carpet surface based on that an intensity of the echo signal is less than an intensity of a standard echo signal, wherein the echo signal is capable of exhibiting diffuse reflection within the sleeve.

Abstract: An electromagnetic wave control apparatus includes an upper electrode layer, a lower electrode layer, a liquid crystal layer, and a first metamaterial layer disposed between the upper electrode layer and the lower electrode layer. The first metamaterial layer includes a first array including alignment unit structures. A first surface of the alignment unit structure is a surface that is of the alignment unit structure and that faces away from the liquid crystal layer. A length-to-width ratio of the first surface of the alignment unit structure is greater than 1. A length of the first surface, a width of the first surface, and a spacing between two adjacent alignment unit structures range from 1 nm to 5000 nm.

Abstract: Provided are a mutant of an immunoglobulin degrading enzyme IdeE, a protein including the mutant, and a use of a composition and a kit in preparation of a drug for reducing the level of IgG in a subject. The mutant has amino acid substitution, N-terminal truncated and/or C-terminal truncated on one or more of positions 8, 10, 24, 59, 97, and 280 of the amino acid sequence shown in SEQ ID NO: 2, and the mutant has the function of the immunoglobulin degrading enzyme IdeE, and has higher activity and thermal stability than wild-type IdeE.

Abstract: A carpet recognition method for a robot cleaner. The robot cleaner comprises a sleeve and an ultrasonic sensor, wherein the ultrasonic sensor is fixed in the sleeve. The recognition method comprises: controlling the ultrasonic sensor to vertically transmit an ultrasonic signal to the current ground, and to receive an actual echo signal reflected by the current ground; and determining whether the actual echo signal is different from the standard echo signal of the normal ground, and if so, recognizing the current ground as a carpet surface.

Abstract: Provided are a mutant of an immunoglobulin degrading enzyme IdeE, a protein comprising the mutant, and a use of a composition and a kit in preparation of a drug for reducing the level of IgG in a subject. The mutant has amino acid substitution, N-terminal truncated and/or C-terminal truncated on one or more of positions 8, 10, 24, 59, 97, and 280 of the amino acid sequence shown in SEQ ID NO: 2, and the mutant has the function of the immunoglobulin degrading enzyme IdeE, and has higher activity and thermal stability than wild-type IdeE.

Abstract: Provided is a molecule comprising an Fc variant. Compared with a molecule comprising an IgG wild-type Fc, the molecule is resistant to the degradation of an immunoglobulin enzyme, and the molecule comprises a human IgG Fc region having a mutation, the mutation being one or more substitutions or deletions at a G237 position (EU numbering), and the substitution preferably being G237A. Further provided are a nucleic acid encoding the molecule, a vector comprising the nucleic acid and a host cell, and a method for preparing the molecule.

Abstract: An antibiotic pharmaceutical composition for intradermal or subcutaneous administration is provided, which includes an antibiotic and hyaluronidase (HAase). In the antibiotic pharmaceutical composition, a content of the antibiotic is 10 mg/mL-5 g/Ml, and a content of the HAase is 45 units/ml-4500000 units/ml. A kit is provided, which includes the pharmaceutical composition. A method for preparing the kit, and use of the pharmaceutical composition are further provided.

Abstract: The present disclosure provides a pharmaceutical composition or drug kit for alleviating or treating fibrotic diseases, and a use thereof. Disclosed is a novel medication regimen in which a platelet endothelial aggregation receptor 1 (PEAR1) agonist and pirfenidone or nintedanib are used in combination.

Abstract: An information management method, a device, and a medium. The information management method applied to a first terminal, including: sending an information acquisition request to a server, so that the server responds to the information acquisition request and sends visitor information to the first terminal; receiving the visitor information sent by the server; generating card information according to the visitor information; and sending the card information to an electronic card, so that the electronic card displays the card information.

Abstract: The present invention provides a high-strength and high-plasticity titanium matrix composite and a preparation method thereof. The preparation method includes: preparing high-oxygen hydride-dehydride titanium powder using a high-temperature rotary ball grinding treatment process, in which the prepared hydride-dehydride titanium powder has a particle size of 10-40 ?m, and has an oxygen content of 0.8-1.5 wt. %; preparing high-purity ultra-fine oxygen adsorbent powder using a wet grinding method of high-energy vibration ball grinding treatment process; in which a purity of the oxygen adsorbent powder is ?99.9%, and a particle size of the oxygen adsorbent powder is ?8 ?m; mixing the high-oxygen hydride-dehydride titanium powder with the oxygen adsorbent powder in a protective atmosphere, and then press-forming the powder obtained after mixing to obtain a raw material blank; and performing atmosphere protective sintering treatment on the raw material blank to obtain a titanium matrix composite.

Abstract: Provided are a product and a method for treating thrombocytopenia. The product and the method can fundamentally solve the problem of thrombocytopenia from the perspective of an autoimmune mechanism.

Abstract: An Fc variant containing a 2,6-sialylated glycosylation modification is provided. The Fc variant has an increased affinity for human FcRn and an increased 2,6-sialylation level. The Fc variant can reduce the level of IgG in the blood, and 2,6-sialic acid thereof has an anti-inflammatory effect. A protein, composition or kit including the Fc variant is also provided.

Abstract: Disclosed is an invasion correction method and system for resistivity logging. The method includes the steps of: analyzing mud filtrate invasion features based on an actual resistivity logging curve; determining an invasion mechanism, and performing forward modeling on a resistivity logging response; performing inversion by a random forest method to form a correction chart; and outputting a formation resistivity to finally form the invasion correction method and system for resistivity logging. In the present disclosure, double lateral correction under an invasion condition is accomplished, while a chart method and an inversion method are combined, ensuring the accuracy and operating rate of correction.

Abstract: An information management method, a device, a system and a medium. The information management method applied to a first terminal, including: sending an information acquisition request to a server, so that the server responds to the information acquisition request and sends visitor information to the first terminal; receiving the visitor information sent by the server; generating card information according to the visitor information; and sending the card information to an electronic card, so that the electronic card displays the card information.

Abstract: A three-dimensional (3D) magnetic particle imaging (MPI) method and system without rotating a field-free line (FFL) are disclosed. In accordance with the method, an FFL is generated such that magnetic particles in a region far from the FFL enter a magnetic saturation state. Further, a non-uniform mixed-frequency excitation magnetic field parallel to the FFL is applied to generate intermodulation response signals. In addition, the intermodulation response signals are acquired, amplified and filtered. Moreover, the intermodulation response signals are transmitted to a digital signal processing unit and an image reconstruction unit, and an encoding matrix is constructed. Additionally, a one-dimensional (1D) concentration distribution of the magnetic particles is reconstructed based on the encoding matrix and an actually measured voltage signal. The FFL is driven for line-by-line scanning along a vertical plane of the FFL, thereby achieving 3D imaging.