Abstract: The invention discloses a distributed IoT terminal system and method based on a fiber optic bus RoF. The system comprises a core application part, a pre-channel part, a transmission channel part, an acquisition field part, an acquisition terminal part and a data source. The invention adopts the principle of light-borne ROF to adapt to pan-socialization, decentralization, verticalization, refinement, full traceability, full lifecycle management and governance, instant, real-time, online, interactive and distributed IoT applications. The integrated and integrated application of the invention improves social efficiency and saves social cost. It may be integrated and integrated the application into any application systems, and realized dynamic instant, real-time, online, centimeter level positioning application. It can infer the specific location of the positioning device.

Abstract: Provided herein are tetravalent antigen binding complexes having agonist activity for a cell surface receptor. In some embodiments, the complexes comprise binding specificities for multiple epitopes of the same cell surface receptor. Further provided herein are nucleic acids, vectors, host cells, pharmaceutical compositions, and methods of production related thereto.

Abstract: Biological macromolecules have tremendous potential for the treatment of disease of the central nervous system (CNS), however, the presence of the blood brain barrier (BBB) makes achieving a therapeutically relevant antibody concentration extremely challenging. Antibodies with enhanced neutral pH affinity for the neonatal Fc receptor demonstrate improved accumulation in the brain. Variants disclosed herein also enhanced exposure in engineered mouse models. Using an anti-BACE1 antibody, these Fc variants significantly reduced the levels of brain Abeta.

Abstract: The invention discloses a distributed IoT terminal system and method based on a fiber optic bus RoF. The system comprises a core application part, a pre-channel part, a transmission channel part, an acquisition field part, an acquisition terminal part and a data source. The invention adopts the principle of light-borne ROF to adapt to pan-socialization, decentralization, verticalization, refinement, full traceability, full lifecycle management and governance, instant, real-time, online, interactive and distributed IoT applications. The integrated and integrated application of the invention improves social efficiency and saves social cost. It may be integrated and integrated the application into any application systems, and realized dynamic instant, real-time, online, centimeter level positioning application. It can infer the specific location of the positioning device.

Abstract: Provided herein are tetravalent antigen binding complexes having agonist activity for a cell surface receptor. In some embodiments, the complexes comprise binding specificities for multiple epitopes of the same cell surface receptor. Further provided herein are nucleic acids, vectors, host cells, pharmaceutical compositions, and methods of production related thereto.

Abstract: Provided herein are antigen binding polypeptides and complexes thereof having agonist activity. Also provided are methods for screening for complexes or polypeptides having agonist activity, enhancing the agonist activity of a polypeptide, and for agonizing a cell surface receptor using the complexes and polypeptide described herein.

Abstract: Provided herein are antigen binding polypeptides and complexes thereof having agonist activity. Also provided are methods for screening for complexes or polypeptides having agonist activity, enhancing the agonist activity of a polypeptide, and for agonizing a cell surface receptor using the complexes and polypeptide described herein.

Abstract: Provided herein are tetravalent antigen binding complexes having agonist activity for a cell surface receptor. In some embodiments, the complexes comprise binding specificities for multiple epitopes of the same cell surface receptor. Further provided herein are nucleic acids, vectors, host cells, pharmaceutical compositions, and methods of production related thereto.

Abstract: Provided herein are antigen binding polypeptides and complexes thereof having agonist activity. Also provided are methods for screening for complexes or polypeptides having agonist activity, enhancing the agonist activity of a polypeptide, and for agonizing a cell surface receptor using the complexes and polypeptide described herein.

Abstract: Methods and apparatus are disclosed for detecting whether a gear-driven fuel pump has been installed correctly in a fuel injected IC engine, the pump gear being driven by an engine gear to provide fuel to injectors via a fuel rail. The method may include providing a pump element pumping event. The method may also include disabling overlapping fuel injectors and overlapping pumping events during the test period surrounding the selected pumping event, and measuring the pressure in the rail during the pumping event with the overlapping injectors disabled, the at least two different engine crank angles surrounding the pumping event. The method also may further include determining from the measured rail pressures whether the pumping event occurred at a desired engine crank angle. Apparatus to carry out the methods may include a computer programmed for controlling the sequence of the providing, disabling, measuring, and determining functions, as well as software for carrying out the respective functions.

Abstract: Methods and apparatus are disclosed for detecting whether a gear-driven fuel pump has been installed correctly in a fuel injected IC engine, the pump gear being driven by an engine gear to provide fuel to injectors via a fuel rail. The method may include providing a pump element pumping event. The method may also include disabling overlapping fuel injectors and overlapping pumping events during the test period surrounding the selected pumping event, and measuring the pressure in the rail during the pumping event with the overlapping injectors disabled, the at least two different engine crank angles surrounding the pumping event. The method also may further include determining from the measured rail pressures whether the pumping event occurred at a desired engine crank angle. Apparatus to carry out the methods may include a computer programmed for controlling the sequence of the providing, disabling, measuring, and determining functions, as well as software for carrying out the respective functions.