Patents by Inventor Yanling DU
Yanling DU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12642778Abstract: The use of a mitoxantrone hydrochloride liposome and cyclophosphamide, vincristine and prednisone in the preparation of a drug for treating peripheral T-cell lymphoma (PTCL). The PTCL is preferably treatment-naïve PTCL. Other first-line and second-line drugs for treating PTCL may also be further used on the basis of the foregoing. A method for treating PTCL, the method comprising administering, to a patient, a therapeutically effective amount of a mitoxantrone hydrochloride liposome and cyclophosphamide, vincristine and prednisone. The combined administration of the drugs is safe and tolerable, has a small toxicity and few side effects, and can obtain a higher total objective remission rate (ORR) in treatment-naïve PTCL patients.Type: GrantFiled: August 26, 2021Date of Patent: June 2, 2026Assignee: CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., LtdInventors: Chunlei Li, Xuefang Xia, Yanhui Li, Na An, Yanling Du, Tong Li, Shixia Wang, Runlu Jia
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Publication number: 20260108478Abstract: The present application provides use of mitoxantrone hydrochloride liposome in treatment of neuromyelitis optica spectrum disorders. The present application further provides a method for treating neuromyelitis optica spectrum disorders in an individual. The method comprises administering to the individual a therapeutically effective amount of mitoxantrone hydrochloride liposome or a pharmaceutical composition comprising mitoxantrone hydrochloride liposome. Animal and clinical test results show that mitoxantrone hydrochloride liposome is safe and effective in treatment of neuromyelitis optica spectrum disorders.Type: ApplicationFiled: July 19, 2023Publication date: April 23, 2026Inventors: Chunlei LI, Jiaqi LIU, Yanhui LI, Yulou YU, Xiugao YANG, Mengmeng LI, Guohua WU, Yanling DU, Meng ZHOU, Shixia WANG, Chao LI
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Publication number: 20260021131Abstract: A mitoxantrone liposome and capecitabine are used in treating nasopharyngeal carcinoma, in particular recurrent and/or metastatic nasopharyngeal carcinoma. Nasopharyngeal carcinoma, in particular recurrent and/or metastatic nasopharyngeal carcinoma, can be treated by administering a therapeutically effective dose of the mitoxantrone liposome and capecitabine to a patient with nasopharyngeal carcinoma.Type: ApplicationFiled: August 28, 2023Publication date: January 22, 2026Inventors: Chunlei LI, Yanping LIU, Mengmeng LI, Wei HUANG, Yanling DU, Lijuan HE, Shixia WANG, Qi DONG, Dong WANG, Jianfei XUE
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Patent number: 11923685Abstract: A reactive power-voltage control method for integrated transmission and distribution networks is provided. The reactive power-voltage control method includes: establishing a reactive power-voltage control model for a power system consisting of a transmission network and a plurality of distribution networks; performing a second order cone relaxation on a non-convex constraint of the plurality of distribution network constraints to obtain the convex-relaxed reactive power-voltage control model; solving the convex-relaxed reactive power-voltage control model to acquire control variables of the transmission network and control variables of each distribution network; and controlling the transmission network based on the control variables of the transmission network and controlling each distribution network based on the control variables of the distribution network, so as to realize coordinated control of the power system.Type: GrantFiled: June 14, 2021Date of Patent: March 5, 2024Assignees: TSINGHUA UNIVERSITY, STATE GRID JIBEI ELECTRIC POWER COMPANYInventors: Bin Wang, Yanling Du, Wenchuan Wu, Haitao Liu, Hongbin Sun, Guannan Wang, Qinglai Guo, Qi Wang, Chenhui Lin
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Publication number: 20240058280Abstract: The present application provides a use of mitoxantrone hydrochloride liposome in the preparation of a medicament for treating ovarian cancer, gastric cancer or head and neck squamous cell carcinoma, a method for treating ovarian cancer, gastric cancer or head and neck squamous cell carcinoma using a mitoxantrone hydrochloride liposome formulation, and a mitoxantrone hydrochloride liposome formulation for treating ovarian cancer, gastric cancer or head and neck squamous cell carcinoma.Type: ApplicationFiled: December 14, 2021Publication date: February 22, 2024Inventors: Chunlei LI, Yanping LIU, Caixia WANG, Yanling DU, Xiaoyan WANG, Xueying SHEN, Shixia WANG, Shanshan SUN
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Publication number: 20240024257Abstract: The use of a mitoxantrone hydrochloride liposome and cyclophosphamide, vincristine and prednisone in the preparation of a drug for treating peripheral T-cell lymphoma (PTCL). The PTCL is preferably treatment-naïve PTCL. Other first-line and second-line drugs for treating PTCL may also be further used on the basis of the foregoing. A method for treating PTCL, the method comprising administering, to a patient, a therapeutically effective amount of a mitoxantrone hydrochloride liposome and cyclophosphamide, vincristine and prednisone. The combined administration of the drugs is safe and tolerable, has a small toxicity and few side effects, and can obtain a higher total objective remission rate (ORR) in treatment-naïve PTCL patients.Type: ApplicationFiled: August 26, 2021Publication date: January 25, 2024Inventors: Chunlei Li, Xuefang Xia, Yanhui Li, Na An, Yanling Du, Tong Li, Shixia Wang, Runlu Jia
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Publication number: 20230420943Abstract: The present application relates to a direct-drive wind farm parameter tuning method and system considering the interaction between generators, which belongs to the technical field of wind power generation. It solves the problem that the interaction between generators is not considered in the direct-drive wind farm in the prior art, the system stability level cannot be effectively evaluated online, and parameter configuration is unreasonable.Type: ApplicationFiled: March 22, 2023Publication date: December 28, 2023Inventors: Jing MA, Honglu XU, Yawen DENG, Shuqiang ZHAO, Yanling DU, Jingran WANG, Zhiqian YANG, Dangsheng ZHOU
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Publication number: 20230078702Abstract: Mitoxantrone hydrochloride liposome is a unique active ingredient for preparing drugs for treating breast cancer. The breast cancer is preferably advanced breast cancer. A method for treating the breast cancer includes to administer mitoxantrone hydrochloride liposome in a therapeutic effective amount to breast cancer patients, and the therapeutic effective amount means 8-30 mg/m2, according to mitoxantrone. Clinical trial results show that the mitoxantrone hydrochloride liposome has better efficacy and fewer adverse reactions, and especially significantly reduced cardiotoxicity, compared with a common mitoxantrone hydrochloride injection.Type: ApplicationFiled: February 9, 2021Publication date: March 16, 2023Inventors: Chunlei LI, Xiaodong WANG, Xiugao YANG, Lingling WANG, Yanling DU, Qiushuang JIN, Shixia WANG, Xiaoli WANG
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Patent number: 11342753Abstract: The present disclosure provides a scheduling method for a power system based on flexible HVDC (high-voltage direct current) and a pumped storage power station, which belongs to a field of power system control technologies. The method is applicable in a power system having a flexible HVDC system and a pumped storage power station. By establishing a scheduling model for the power system, which contains an objective function and multiple constraints, and solving the scheduling model, a capability of the pumped storage power station is used to adjust the unstable output of the renewable energy power generator and stabilize fluctuant of the renewable energy power generation, such that a power incoming into a load center presents a stable ladder pattern and an optimal scheduling scheme can be obtained.Type: GrantFiled: September 23, 2020Date of Patent: May 24, 2022Assignees: TSINGHUA UNIVERSITY, STATE GRID JIBEI ELECTRIC POWER COMPANY, STATE GRID CORPORATION OF CHINAInventors: Bin Wang, Yanling Du, Wenchuan Wu, Haitao Liu, Hongbin Sun, Weimin Sun, Zongda Mu, Chenhui Lin, Qinglai Guo
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Patent number: 11228179Abstract: The present disclosure proposes a decomposition-coordination voltage control method for wind power to be transmitted to a nearby area via flexible DC. The method includes: initializing parameters; sending the parameters to wind power farms; for each of the wind power farms, establishing a voltage control optimization sub-model; solving the voltage control optimization sub-model to obtain a first optimal result; for the control center, establishing a voltage control optimization main model; solving the voltage control optimization main model to obtain a second optimal result; calculating a determination index based on the first optimal result and the second optimal result; and determining whether the determination index is convergent to an admissible value, if no, updating the parameters and returning to establishing the voltage control optimization sub-model.Type: GrantFiled: April 14, 2020Date of Patent: January 18, 2022Assignees: TSINGHUA UNIVERSITY, STATE GRID BEIJING ELECTRIC POWER COMPANY, STATE GRID JIBEI ELECTRIC POWER COMPANYInventors: Bin Wang, Hongquan Ji, Yanling Du, Qinglai Guo, Xijuan Yu, Haitao Liu, Hongbin Sun, Guannan Wang, Mang Jiang, Huaichang Ge, Wenchuan Wu
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Publication number: 20210391722Abstract: A reactive power-voltage control method for integrated transmission and distribution networks is provided. The reactive power-voltage control method includes: establishing a reactive power-voltage control model for a power system consisting of a transmission network and a plurality of distribution networks; performing a second order cone relaxation on a non-convex constraint of the plurality of distribution network constraints to obtain the convex-relaxed reactive power-voltage control model; solving the convex-relaxed reactive power-voltage control model to acquire control variables of the transmission network and control variables of each distribution network; and controlling the transmission network based on the control variables of the transmission network and controlling each distribution network based on the control variables of the distribution network, so as to realize coordinated control of the power system.Type: ApplicationFiled: June 14, 2021Publication date: December 16, 2021Inventors: Bin WANG, Yanling DU, Wenchuan WU, Haitao LIU, Hongbin SUN, Guannan WANG, Qinglai GUO, Qi WANG, Chenhui LIN
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Publication number: 20210119453Abstract: The present disclosure proposes a decomposition-coordination voltage control method for wind power to be transmitted to a nearby area via flexible DC. The method includes: initializing parameters; sending the parameters to wind power farms; for each of the wind power farms, establishing a voltage control optimization sub-model; solving the voltage control optimization sub-model to obtain a first optimal result; for the control center, establishing a voltage control optimization main model; solving the voltage control optimization main model to obtain a second optimal result; calculating a determination index based on the first optimal result and the second optimal result; and determining whether the determination index is convergent to an admissible value, if no, updating the parameters and returning to establishing the voltage control optimization sub-model.Type: ApplicationFiled: April 14, 2020Publication date: April 22, 2021Inventors: Bin WANG, Hongquan JI, Yanling DU, Qinglai GUO, Xijuan YU, Haitao LIU, Hongbin SUN, Guannan WANG, Mang JIANG, Huaichang GE, Wenchuan WU
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Publication number: 20210111562Abstract: The present disclosure provides a scheduling method for a power system based on flexible HVDC (high-voltage direct current) and a pumped storage power station, which belongs to a field of power system control technologies. The method is applicable in a power system having a flexible HVDC system and a pumped storage power station. By establishing a scheduling model for the power system, which contains an objective function and multiple constraints, and solving the scheduling model, a capability of the pumped storage power station is used to adjust the unstable output of the renewable energy power generator and stabilize fluctuant of the renewable energy power generation, such that a power incoming into a load center presents a stable ladder pattern and an optimal scheduling scheme can be obtained.Type: ApplicationFiled: September 23, 2020Publication date: April 15, 2021Inventors: Bin WANG, Yanling DU, Wenchuan WU, Haitao LIU, Hongbin SUN, Weimin SUN, Zongda MU, Chenhui LIN, Qinglai GUO