Abstract: Disclosed is a pyridazinone compound represented by Formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, stereoisomer, or isotopic variant thereof. The compound can be used for preparation of medicinal products for treatment and/or prophylaxis of a disease or condition associated with thyroid hormone abnormalities. The compound has higher selectivity to TH?, better pharmacokinetic parameters, desired stability, and higher agonistic activity toward TH?.

Abstract: A reactive power-voltage control method for integrated transmission and distribution networks is provided. The reactive power-voltage control method includes: establishing a reactive power-voltage control model for a power system consisting of a transmission network and a plurality of distribution networks; performing a second order cone relaxation on a non-convex constraint of the plurality of distribution network constraints to obtain the convex-relaxed reactive power-voltage control model; solving the convex-relaxed reactive power-voltage control model to acquire control variables of the transmission network and control variables of each distribution network; and controlling the transmission network based on the control variables of the transmission network and controlling each distribution network based on the control variables of the distribution network, so as to realize coordinated control of the power system.

Abstract: Various embodiments described herein relate to calculating asset capability using model predictive control and/or industrial process optimization. In this regard, an optimization request to optimize an industrial process that produces an industrial process product is received. In response to the optimization request, asset modeling data is obtained from one or more asset performance management systems for an asset associated with the industrial process. Also in response to the optimization request, one or more real-time operating limits for the industrial process are adjusted based at least in part on the asset modeling data obtained from the one or more asset performance management systems. Furthermore, a control signal configured based at least in part on the one or more real-time operating limits is transmitted to a controller configured for optimization associated with the industrial process that produces the industrial process product.

Abstract: Various embodiments described herein relate to advanced process control for assets and/or processes using instance-based learning. In this regard, an event indicator related to a change event associated with operation of an asset is received. In response to the event indicator, one or more insights for one or more real-time settings for the asset are determined based at least in part on a comparison between a current operating condition digital signature for the asset and historical operating condition digital signature for the asset. Additionally, the one or more real-time settings for the asset are adjusted based on the one or more insights to provide one or more adjusted settings for the asset.

Abstract: Various embodiments described herein relate to intelligently detecting and predicting asset anomalies and faults. Such detection is enabled by generating feature that capture relationships between asset sensor values and different operation conditions or states of assets. In this regard, one or more features based at least on sensor data collected from a plurality of sensors associated with an asset are generated, and a data stream comprising data associated with the asset is received. An anomaly score for the data stream is then determined based at least on the one or more features. In accordance with determining whether the anomaly score is indicative of a potential fault of the asset, fault data indicative of the potential fault is generated, and presentation of the fault data and an indication of the one or more features considered in the determination of the anomaly score via the user interface is caused.

Abstract: A system for separating solids from fluid including a solid-laden fluid may include a base fluid, a first separator configured to receive the solid-laden fluid and separate the fluid into a solids portion and an effluent, and a membrane separator configured to receive the effluent and separate the effluent into a permeate and a concentrate. A method for separating solids from fluid may include obtaining a solid-laden fluid, wherein the solid-laden fluid comprises a base fluid, feeding the solid-laden fluid through a centrifuge, removing at least a portion of high gravity solids from the solid-laden fluids, flowing the solid-laden fluid through a membrane separator, removing at least a portion of low gravity solids from the solid-laden fluid, and collecting a permeate from the membrane separator.

Abstract: A system for separating solids from fluid including a solid-laden fluid including a base fluid, a first separator configured to receive the solid-laden fluid and separate the fluid into a solids portion and an effluent, and a membrane separator configured to receive the effluent and separate the effluent into a permeate and a concentrate is disclosed. A method for separating solids from fluid including obtaining a solid-laden fluid, wherein the solid-laden fluid comprises a base fluid, feeding the solid-laden fluid through a centrifuge, removing at least a portion of high gravity solids from the solid-laden fluids, flowing the solid-laden fluid through a membrane separator, removing at least a portion of low gravity solids from the solid-laden fluid, and collecting a permeate from the membrane separator is also disclosed.

Abstract: The present invention provides a screening method for a compound capable of inducing regulatory T cells, comprising the following steps: (1) a step for culturing CD4+ T cells having a naïve phenotype in the presence of a test compound, and isolating T cells from the culture product; (2) a step for evaluating the immunosuppressive function of the T cells isolated in the step (1); (3) a step for obtaining the foregoing test compound as a compound capable of inducing regulatory T cells if the results of the evaluation in the step (2) show that the T cells isolated in the step (1) have immunosuppressive function. The present invention also provides a method of producing regulatory T cells, comprising culturing CD4+ T cells having a naïve phenotype in the presence of a rapamycin compound to obtain regulatory T cells.