Patents by Inventor Yanming Du

Yanming Du has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and Compositions for Treating Hematologic Malignancies
    Publication number: 20230151021
    Abstract: The present disclosure relates, in part, to certain compounds comprising brusatol derivatives, or a pharmaceutically acceptable salt, solvate, or polymorph thereof, which are useful for the treatment of hematological malignancies, including but not limited to leukemia and lymphoma. In certain embodiments, the present disclosure relates to pharmaceutical compositions of the compounds of the present disclosure.
    Type: Application
    Filed: April 27, 2021
    Publication date: May 18, 2023
    Inventors: Erle S. Robertson, Yonggang Pei, Yanming Du
  • QUINOLINE INHIBITORS OF RAD52 AND METHODS OF USE
    Publication number: 20220388980
    Abstract: The present disclosure related to compounds of Formula I and Formula I and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating RAD52 activity and may be used in the treatment of disorders in which RAD52 activity is implication, such as a cancer.
    Type: Application
    Filed: October 1, 2020
    Publication date: December 8, 2022
    Inventors: Alexander V. Mazin, Patrick Y. S. Lam, Kritika Hanamshet, Mikir Sunil Patel, Yanming Du, Nicki Hwang
  • Bicyclic Carboxamide with Exocyclic Urea Derivatives as Antivirals for the Treatment of HBV Infection
    Publication number: 20210371388
    Abstract: Pharmaceutical compositions of the invention comprise functionalized bicyclic carboxamide useful as pregenomic RNA encapsidation inhibitors, useful for the treatment of Hepatitis B virus (HBV) infection.
    Type: Application
    Filed: May 12, 2021
    Publication date: December 2, 2021
    Inventors: Yanming Du, Ju-Tao Guo, Nicky Hwang
  • BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS
    Publication number: 20210347752
    Abstract: Pharmaceutical compositions of the invention comprise functionalized benzamide derivatives useful as cyclic GMP-AMP synthase-Stimulator of interferon gene (cGAS-STING) pathway agonists, and useful for treating viral diseases and boost antitumor immunity.
    Type: Application
    Filed: October 1, 2019
    Publication date: November 11, 2021
    Inventors: Jinhong CHANG, Yanming DU, Ju-Tao GUO
  • Substituted aminothiazoles
    Patent number: 10913734
    Abstract: Described herein are substituted aminothiazoles, compositions comprising same; and methods of making and using same.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: February 9, 2021
    Inventors: Yanming Du, Huagang Lu, John Rogowsky, William A. Kinney, Andrea Cuconati
  • 2,3-diacylated, 2- and 3-mono-acylated alkylated imino sugars exhibiting glucosidase inhibition and their method of use
    Patent number: 10421723
    Abstract: Described herein are alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity that include viral hemorrhagic fevers and other enveloped viruses, and any other diseases involving glucosidase activity.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: September 24, 2019
    Inventors: Yanming Du, Jinhong Chang, Timothy Michael Block
  • Alkylated imino sugars exhibiting glucosidase inhibition and their method of use
    Patent number: 10376502
    Abstract: Pharmaceutical compositions of the invention comprise alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity that include Viral hemorrhagic fevers, and any other diseases involving glucosidase activity.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: August 13, 2019
    Inventors: Yanming Du, Xiaodong Xu, Hong Ye, Jinhong Chang, Timothy M. Block
  • SUBSTITUTED AMINOTHIAZOLES
    Publication number: 20190241552
    Abstract: Described herein are substituted aminothiazoles, compositions comprising same; and methods of making and using same.
    Type: Application
    Filed: July 11, 2017
    Publication date: August 8, 2019
    Inventors: Yanming DU, Huagang LU, John ROGOWSKY, William A. KINNEY, Andrea CUCONATI
  • FUNCTIONALIZED BENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION
    Publication number: 20190092720
    Abstract: Pharmaceutical compositions of the invention comprise functionalized benzamide derivatives useful as pregenomic RNA encapsidation inhibitors, useful for the treatment of Hepatitis B virus (HBV) infection.
    Type: Application
    Filed: November 28, 2018
    Publication date: March 28, 2019
    Inventors: XIAODONG XU, TIMOTHY M. BLOCK, JU-TAO GUO, YANMING DU
  • Antimicrobial Compounds And Methods Of Making And Using The Same
    Publication number: 20180334439
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
    Type: Application
    Filed: December 18, 2017
    Publication date: November 22, 2018
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Marco Devivo, Yanming Du, Sandra Sinishtaj, Yuanqing Tang, Brian T. Wimberly
  • NOVEL ANTIVIRAL AGENTS AGAINST HBV INFECTION
    Publication number: 20180230092
    Abstract: The present invention is directed toward novel compounds and novel methods of use of said compounds of the formula (I), useful as nucleocapsid assembly inhibitors for the treatment of viruses, especially but not exclusively, including pregenomic RNA encapsidation inhibitors of HBV for the treatment of Hepatitis B virus (HBV) infection and related conditions. including hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, wherein A, R1, R2, R3, R4, R5, R6, R7, and R8 are defined herein.
    Type: Application
    Filed: March 22, 2018
    Publication date: August 16, 2018
    Inventors: XIAODONG XU, JU-TAO GUO, TONG XIAO, YANMING DU, TIMOTHY BLOCK, SIMON DAVID PETER BAUGH, HONG YE
  • Antiviral agents against HBV infection
    Patent number: 9938236
    Abstract: The present invention provides novel compounds of formula (I) and methods of use thereof. In certain embodiments, the compounds of the invention are useful as nucleocapsid assembly inhibitors. In other embodiments, the compounds of the invention are useful as pregenomic RNA encapsidation inhibitors of Hepatitis B virus (HBV). In yet other embodiments, the compounds of the invention are useful for the treatment of viral infection, including HBV and related viral infections.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: April 10, 2018
    Assignees: Drexel University, Baruch S. Blumberg Institute, Arbutus Biopharma, Inc.
    Inventors: Xiaodong Xu, Ju-Tao Guo, Tong Xiao, Yanming Du, Timothy Block, Simon David Peter Baugh, Hong Ye
  • Macrocyclic Compounds And Methods Of Making And Using The Same
    Publication number: 20180066007
    Abstract: The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
    Type: Application
    Filed: April 21, 2017
    Publication date: March 8, 2018
    Inventors: Jay J. Farmer, Ashoke Bhattacharjee, Yi Chen, Joel A. Goldberg, Joseph A. Ippolito, Zoltan F. Kanyo, Rongliang Lou, Adegboyega K. Oyelere, Edward C. Sherer, Joyce A. Sutcliffe, Deping Wang, Yusheng Wu, Yanming Du
  • Antimicrobial compounds and methods of making and using the same
    Patent number: 9845297
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: December 19, 2017
    Assignee: Melinta Therapeutics, Inc.
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Marco DeVivo, Yanming Du, Sandra Sinishtaj, Yuanqing Tang, Brian T. Wimberly
  • Novel diacylated and mono-acylated alkylated imino sugars exhibiting glucosidase inhibition and their method of use
    Publication number: 20170305856
    Abstract: Described herein are alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity that include viral hemorrhagic fevers and other enveloped viruses, and any other diseases involving glucosidase activity.
    Type: Application
    Filed: April 20, 2017
    Publication date: October 26, 2017
    Inventors: Yanming Du, Jinhong Chang, Timothy Michael Block
  • ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20160031828
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
    Type: Application
    Filed: October 16, 2015
    Publication date: February 4, 2016
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Marco DeVivo, Yanming Du, Sandra Sinishtaj, Yuanqing Tang, Brian T. Wimberly
  • NOVEL ANTIVIRAL AGENTS AGAINST HBV INFECTION
    Publication number: 20160024004
    Abstract: The present invention provides novel compounds of formula (I) and methods of use thereof. In certain embodiments, the compounds of the invention are useful as nucleocapsid assembly inhibitors. In other embodiments, the compounds of the invention are useful as pregenomic RNA encapsidation inhibitors of Hepatitis B virus (HBV). In yet other embodiments, the compounds of the invention are useful for the treatment of viral infection, including HBV and related viral infections.
    Type: Application
    Filed: December 27, 2013
    Publication date: January 28, 2016
    Inventors: XIAODONG XU, JU-TAO GUO, TONG XIAO, YANMING DU, TIMOTHY BLOCK, SIMON DAVID PETER BAUGH, HONG YE
  • Antimicrobial compounds and methods of making and using the same
    Patent number: 9216979
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: December 22, 2015
    Assignee: Melinta Therapeutics, Inc.
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Marco DeVivo, Yanming Du, Sandra Sinishtaj, Yuanqing Tang, Brian T. Wimberly
  • Novel Alkylated Imino Sugars Exhibiting Glucosidase Inhibition and Their Method of Use
    Publication number: 20150335630
    Abstract: Pharmaceutical compositions of the invention comprise alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity that include Viral hemorrhagic fevers, and any other diseases involving glucosidase activity.
    Type: Application
    Filed: July 30, 2015
    Publication date: November 26, 2015
    Inventors: Yanming Du, Xiaodong Xu, Hong Ye, Jinhong Chang, Timothy M. Block
  • FUNCTIONALIZED BENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION
    Publication number: 20150307443
    Abstract: Pharmaceutical compositions of the invention comprise functionalized benzamide derivatives useful as pregenomic RNA encapsidation inhibitors, and are useful for the treatment of Hepatitis B virus (HBV) infection.
    Type: Application
    Filed: December 5, 2013
    Publication date: October 29, 2015
    Inventors: XIAODONG XU, TIMOTHY M. BLOCK, JU-TAO GUO, YANMING DU