Abstract: The present invention provides an in vitro method for detecting immunosuppressive fibroblasts, in particular Cancer Associated Fibroblast (CAFs) in a cancer sample from a subject suffering from cancer, wherein the method comprises detecting ANTXR1+ fibroblasts in the cancer sample from said patient. The invention also concerns an in vitro method for predicting a response of a subject suffering from cancer to an immunotherapy treatment, an immunotherapy treatment for use in the treatment of a cancer in a patient, the use of ANTXR1 as a biomarker for the identification of immunosuppressive fibroblasts, in particular immunosuppressive CAFs, an agent targeting ANTXR1+ fibroblasts for use in the treatment of a cancer in a patient, and a product or kit comprising a) an agent targeting ANTXR1+ fibroblasts and b) an immunotherapy treatment.

Abstract: The present invention provides an in vitro method for selecting a patient affected with a tumor for an immunotherapy treatment or for predicting the response of a subject affected with a tumor to an immunotherapy treatment, wherein the method comprises: (a) detecting DPP4+ CAFs (Cancer Associated Fibroblast), and/or CD73+ CAFs, and/or B7H3+ CAFs, and/or OX40L+ CAFs, and/or JAM2+ CAFs in a cancer sample from said patient; (b) determining the level(s) of DPP4+ CAFs, and/or CD73+ CAFs, and/or B7H3+ CAFs, and/or OX40L+ CAFs, and/or JAM2+ CAFs in said cancer sample, wherein the responsiveness of said patient to an immunotherapy treatment is inversely proportional to the level(s) of DPP4+ CAFs, and/or CD73+ CAFs, and/or B7H3+ CAFs, and/or OX40L+ CAFs, and/or JAM2+ CAFs in the cancer sample; (c) optionally, selecting patients with low level(s) of DPP4+ CAFs, and/or CD73+ CAFs, and/or B7H3+ CAFs, and/or OX40L+ CAFs, and/or JAM2+ CAFs as suitable for an immunotherapy treatment.

Abstract: The present invention relates to compositions and methods for detecting, managing or monitoring cancer. The invention also relates to antibodies specific for cancer markers, compositions and chips containing the same, as well as their uses for cancer detection, managing, monitoring, imaging or treatment, as well as for drug development. The invention is particularly suited for detecting, managing or monitoring lung cancer in human subjects.