Abstract: The present invention relates to a method of calibrating a thermal FEM-model of a turbomachine, the method comprising: i) creating a meta-model of the thermal FEM-model; ii) feeding, for a set of thermal variables, a set of input values to the meta-model for a calculation in the meta-model; iii) obtaining a set of output values from the calculation in the meta-model for the set of input values; iv) comparing the set of output values to measurement data of the turbomachine.

Abstract: The present disclosure relates generally to the field of immuno-therapeutics, and particularly relates to novel chimeric polypeptides, e.g., chimeric antigen receptors (CARs) that include a transmembrane domain from CD28 and a hinge domain. In some cases, the hinge domain is capable of promoting dimerization of the CARs. The disclosure also provides compositions and methods useful for producing such molecules, as well as methods for the detection and treatment of health conditions, such as proliferative diseases (e.g., cancer).