Abstract: The present invention relates to systems for low-energy (e.g., 1.0 nJ-7.0 nJ) photoacoustic microscopy and methods for employing such systems. In certain embodiments, such systems employ a low-energy nanosecond pulsed laser beam (NPLB), at least two amplifiers, and a data acquisition system with at least three channels to generate at least three digital signals (e.g., which are averaged and normalized to the energy of the NPLB). In other embodiments, provided herein are systems for combined use of photoacoustic microscopy, dye-based microscopy (e.g., with fluorescein), and optical coherence tomography.

Abstract: Provided herein are room-temperature phosphorescence nanoparticles, methods of preparing the same, and uses of the same.

Abstract: A portable ocular screening device for tracking macular degeneration having a portable body including a graduated focusing mechanism including an inner chamber. The apparatus also includes a monocular eyepiece disposed on the graduated focusing mechanism and a display screen and a processor disposed within the inner chamber. Additionally, a method of monitoring macular degeneration includes providing a monocular screening device having a display screen disposed within a body of the screening device. The method further includes displaying an image and also providing a prompt in response to the display of the image. Subsequently, the method includes receiving a response via an input device, the response indicative of a user's perception of the image and evaluating the response to determine if the response indicates a user accurately perceived the first image.

Abstract: The present invention relates to systems for low-energy (e.g., 1.0 nJ-7.0 nJ) photoacoustic microscopy and methods for employing such systems. In certain embodiments, such systems employ a low-energy nanosecond pulsed laser beam (NPLB), at least two amplifiers, and a data acquisition system with at least three channels to generate at least three digital signals (e.g., which are averaged and normalized to the energy of the NPLB). In other embodiments, provided herein are systems for combined use of photoacoustic microscopy, dye-based microscopy (e.g., with fluorescein), and optical coherence tomography.