Abstract: The disclosure relates to KRASG12D inhibitor compounds having the structure of Formula (A) or Formula (B), pharmaceutical compositions thereof, and methods of use thereof for inhibiting, treating, and/or preventing KRASG12D mutation-associated diseases, disorders and conditions.

Abstract: A battery cell includes a housing, an electrode assembly accommodated in the housing, and an end cover configured to buckle to an opening of the housing. The end cover comprises a first body part, a first end wall, and a first peripheral wall. The first body part is configured to be connected to the housing. The first end wall is farther away from the electrode assembly than the first body part. The first peripheral wall is disposed around an edge of the first end wall and connected to the first body part, and the first peripheral wall and the first end wall jointly form a first accommodation space used to accommodate at least a part of a tab of the electrode assembly. The first peripheral wall comprises a first arc wall extending from the first end wall to the first body part along a first arc trajectory.

Abstract: The disclosure relates to bifunctional KRAS-G12D-modulating compounds having the structure W-L-T, where W is a targeting group that binds specifically to KRAS-G12D protein, T is an E3-ligase binding group, and L is absent or is a bivalent linking group that connects W and T together via a covalent linkage. Compounds and pharmaceutical compositions thereof can promote degradation of the KRAS-G12D protein in a cell and are thus useful for treating, inhibiting, and preventing KRAS-G12D-associated diseases, disorders and conditions, including cancers.

Abstract: A device and a method for determining a microvibration effect on a millisecond-level space optical sensor are provided. The device includes: a light source, a star simulator, an air flotation vibration isolation platform, a suspension system/air flotation system, a zero stiffness system, a supporting system, a six-degree-of-freedom microvibration simulator, a signal driving apparatus, and a data acquisition and processing system. In the device for determining a microvibration effect on a space pointing measurement apparatus, a free boundary condition and a zero gravity environment are simulated by using a suspension system and a zero stiffness system. A light source and a star simulator simulate a star at infinity. A six-degree-of-freedom microvibration simulator simulates an on-orbit microvibration mechanical environment which is used as an input of a test. Extremely high-precision sensors collect system response data.

Abstract: A nanoparticle comprising a shell surrounding a core material with a lower conductivity than the shell material, wherein the core center is offset in relation to the shell center. A method comprising providing a nanoparticle comprising a nonconductive core and a conductive shell, and asymmetrically depositing additional conductive material on the conductive shell. A method comprising providing a concentric nanoshell having a core and a shell, immobilizing the concentric nanoshell onto a support, and asymmetrically depositing a conductive material onto the shell to produce a nanoegg.

Abstract: The invention relates to a light-pipe system for conducting/distributing light and air, which can also purify indoor air, particularly in a building, or the like. The light-pipe system includes a light-pipe for conducting light and having a clear top dome mounted at the top of the light-pipe to let in sunlight but keep out dust, rain and UV. An emitter fitted to the bottom of light-pipe improves the light distribution into the room, and a ventilation stack laid around the light-pipe coaxially/or non-coaxially, and a photocatalyst film (e.g. Nanometer TiO2) coated on the outer surface of the emitter for purifying indoor air under the illumination of light from light-pipe. The air and light are conducted separately along two different transport paths. The light-pipe system can provide illumination, ventilation and air purification simultaneously. The light source may be daylight, artificial light, light storage material or a mixture of them. Air can be moved naturally and/or is transported mechanically.

Abstract: A nanoparticle comprising a shell surrounding a core material with a lower conductivity than the shell material, wherein the core center is offset in relation to the shell center. A method comprising providing a nanoparticle comprising a nonconductive core and a conductive shell, and asymmetrically depositing additional conductive material on the conductive shell. A method comprising providing a concentric nanoshell having a core and a shell, immobilizing the concentric nanoshell onto a support, and asymmetrically depositing a conductive material onto the shell to produce a nanoegg.

Abstract: The invention relates to a light-pipe system for conducting/distributing light and air, which can also purify indoor air, particularly in a building, or the like. The light-pipe system includes a light-pipe for conducting light and having a clear top dome mounted at the top of the light-pipe to let in sunlight but keep out dust, rain and UV. An emitter fitted to the bottom of light-pipe improves the light distribution into the room, and a ventilation stack laid around the light-pipe coaxially/or non-coaxially, and a photocatalyst film (e.g. Nanometer TiO2) coated on the outer surface of the emitter for purifying indoor air under the illumination of light from light-pipe. The air and light are conducted separately along two different transport paths. The light-pipe system can provide illumination, ventilation and air purification simultaneously. The light source may be daylight, artificial light, light storage material or a mixture of them. Air can be moved naturally and/or is transported mechanically.