Abstract: A continuously variable transmission with both equal-difference output and equal-ratio output includes an input mechanism, a hydraulic transmission mechanism, a planetary-gear-set convergence mechanism, an equal-difference output mechanism, an equal-ratio output mechanism, a clutch assembly, and a brake. The clutch assembly connects an output end of the input mechanism to an input end of the hydraulic transmission mechanism and the planetary-gear-set convergence mechanism and connects an output end of the hydraulic transmission mechanism to the planetary-gear-set convergence mechanism. The clutch assembly connects the planetary-gear-set convergence mechanism to the equal-difference output mechanism and the equal-ratio output mechanism. The clutch assembly connects the equal-ratio output mechanism to the equal-difference output mechanism.

Abstract: The disclosure relates to KRASG12D inhibitor compounds having the structure of Formula (A) or Formula (B), pharmaceutical compositions thereof, and methods of use thereof for inhibiting, treating, and/or preventing KRASG12D mutation-associated diseases, disorders and conditions.

Abstract: A continuously variable transmission with both equal-difference output and equal-ratio output includes an input mechanism, a hydraulic transmission mechanism, a planetary-gear-set convergence mechanism, an equal-difference output mechanism, an equal-ratio output mechanism, a clutch assembly, and a brake. The clutch assembly connects an output end of the input mechanism to an input end of the hydraulic transmission mechanism and the planetary-gear-set convergence mechanism and connects an output end of the hydraulic transmission mechanism to the planetary-gear-set convergence mechanism. The clutch assembly connects the planetary-gear-set convergence mechanism to the equal-difference output mechanism and the equal-ratio output mechanism. The clutch assembly connects the equal-ratio output mechanism to the equal-difference output mechanism.

Abstract: The present disclosure provides a combined vaccine against human respiratory syncytial virus (RSV) infection and a method thereof for inducing immune response. The combined vaccine includes; a first composition including an immunologically effective dosage of a replication-deficient human adenovirus type 26 vector contains a nucleotide encoding an antigenic protein of RSV and a pharmaceutically acceptable vector; and a second composition including an immunologically effective dosage of a replication-deficient chimpanzee adenovirus type 63 vector contains a nucleotide encoding an antigenic protein of RSV and a pharmaceutically acceptable vector. The first composition is a primary immunization composition and the second composition is a booster immunization composition, or vice versa. In the present disclosure, the combined vaccine is used for inducing a protective immunity against RSV infection, and a method is provided for generating the protective immunity against RSV infection.

Abstract: The present disclosure relates to a hydraulic support with a quick response function for coal wall spalling, which includes a base, an upright post, a top beam, an extensible canopy, a face guard, and a vibration meter. The vibration meter is mounted on a hydraulic support, and detects a vibration signal of a coal wall in a non-contact mode. The face guard includes a primary face guard, a secondary face guard, and a tertiary face guard connected in sequence. One side, close to a coal wall, of the primary face guard is connected to a quick response device. The quick response device is in signal communication with the vibration meter. After receiving the vibration signal of the coal wall, the quick response device is abutted against the coal wall before the secondary face guard and the tertiary face guard fit the coal wall.

Abstract: A spiral impact drilling machine applicable to rock and soil and a construction method are provided. The drilling machine includes a rock chiseling part, a soil drilling part, a gear, a drill rod, and a drill bit. The rock chiseling part includes an air cylinder. A piston is arranged in the air cylinder. The top of the piston is fixedly connected with to a turbine fan blade. The bottom of the piston is fixedly connected to a force transferring component. The soil drilling part includes a motor. The motor is arranged in the force transferring component. The inner part of the gear is in nested connection with the drill rod. The outer part of the gear is in engaged connection with each of the bottom of the force transferring component and the motor. The bottom of the gear is fixedly connected to the drill rod through a stress component.

Abstract: A spiral impact drilling machine applicable to rock and soil and a construction method are provided. The drilling machine includes a rock chiseling part, a soil drilling part, a gear, a drill rod, and a drill bit. The rock chiseling part includes an air cylinder. A piston is arranged in the air cylinder. The top of the piston is fixedly connected with to a turbine fan blade. The bottom of the piston is fixedly connected to a force transferring component. The soil drilling part includes a motor. The motor is arranged in the force transferring component. The inner part of the gear is in nested connection with the drill rod. The outer part of the gear is in engaged connection with each of the bottom of the force transferring component and the motor. The bottom of the gear is fixedly connected to the drill rod through a stress component.