Abstract: The present disclosure relates to a method for preparing cell microparticles capable of targeting Folr2+ macrophages and the prepared cell microparticles, and the method includes the following steps: S1: culturing macrophages to obtain a macrophage culture; S2: extracting cell microparticles from the macrophage culture. By extracting cell microparticles from macrophages and coupling folic acid molecules on the surface thereof, the present disclosure allows the resulting cell microparticles to target Folr2 bound to the surface of macrophages and accurately deliver drugs such as cyclophosphamide, clodronate, doxorubicin, etc. to the site of kidney injury, thereby efficiently killing nephropathogenic Folr2+ macrophages and reducing systemic nonspecific distribution. The cell microparticles of the present disclosure have the advantages of homing targeting, ease of engineering, low cytotoxicity, and low immunogenicity.

Abstract: The present application discloses a compound depicted by formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The compound provided in the present application can bind effectively to STING and has a good agonistic action on STING protein, and exhibits a good inhibitory effect on multiple tumors. Thus, the compound provided in the present application serves as a STING agonist and can be used for treating various related conditions. The compound provided in the present invention shows a very promising prospect for application thereof in the preparation of a medicament for treating a disease associated with STING activity (in particular, a medicament for treating an inflammatory disease, an allergic disease, an autoimmune disease, an infectious disease, a cancer or a precancerous syndrome) and in the preparation of an immune adjuvant, providing a novel option for clinically screening and/or preparing drugs for diseases associated with STING activity.