Patents by Inventor Yanpu He

Yanpu He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERING IMMUNE CHECKPOINT BLOCKADE NANOBODY-STING DELTA-TM FUSION PROTEIN AS A VERSATILE TREATMENT FOR SOLID TUMOR CANCERS
    Publication number: 20230331795
    Abstract: Disclosed are fusion proteins including a STING?TM protein fused to a nanobody, and compositions thereof that further include a STING agonist. Also disclosed are methods of treating cancer, which is achieved by administering said compositions.
    Type: Application
    Filed: May 4, 2023
    Publication date: October 19, 2023
    Inventors: Angela M. BELCHER, Paula T. HAMMOND, Yanpu HE, Celestine HONG, Shengnan HUANG, Jiahe LI
  • RIBONUCLEOPROTEIN APPROACH TO BOOST THE STING SIGNALING FOR CANCER IMMUNOTHERAPY
    Publication number: 20230210968
    Abstract: Disclosed herein is a non-covalent complex, comprising: a tetramer of a recombinant protein; and an agonist of a Stimulator of Interferon Gene (STING) protein or a pharmaceutically acceptable salt thereof, wherein the recombinant protein comprises a STING protein lacking a transmembrane domain (STING?TM protein). Additionally, provided is a vaccine composition, comprising a non-covalent complex and a pharmaceutically acceptable carrier, wherein the non-covalent complex comprises: a recombinant protein comprising a STING?TM protein and a tumor epitope; and an agonist of a STING protein or a pharmaceutically acceptable salt thereof. Further provided are methods of treating and preventing cancer using the disclosed complexes, pharmaceutical compositions, and vaccines.
    Type: Application
    Filed: June 11, 2021
    Publication date: July 6, 2023
    Inventors: Paula HAMMOND, Yanpu HE, Jiahe LI
  • Argonaute protein-double stranded RNA complexes and uses related thereto
    Patent number: 10994025
    Abstract: The invention relates to methods of improving efficacy and enhancing silencing of target genes using Ago2 protein-dsRNA complex (RNP) of the invention.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: May 4, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Jiahe Li, Paula T. Hammond, Yanpu He, Wade Wang
  • ARGONAUTE PROTEIN-DOUBLE STRANDED RNA COMPLEXES AND USES RELATED THERETO
    Publication number: 20180326092
    Abstract: The invention relates to methods of improving efficacy and enhancing silencing of target genes using Ago2 protein-dsRNA complex (RNP) of the invention.
    Type: Application
    Filed: May 11, 2018
    Publication date: November 15, 2018
    Inventors: Jiahe Je, Paula T. Hammond, Yanpu He, Wade Wang