Abstract: The embodiment of the present invention discloses Hangtaimycin derivatives and their preparation and application. Hangtaimycin derivatives are obtained by fermentation of Streptomyces spectabilis CCTCC M2017417 and its genetically knockout mutant strain in SFMR medium, with further isolation, purification, and alcoholysis. Through screening, Hangtaimycin derivatives showed excellent anti-inflammatory and analgesic, anti-tumor, liver injury protection, cell membrane protection, and drug addiction prevention activities, providing new drug leads for developing related drugs.

Abstract: The present disclosure relates to a field of dry etching technology. The present disclosure provides an ultra-large area scanning reactive ion etching machine and an etching method thereof. The ultra-large area scanning reactive ion etching machine includes: an injection chamber, an etching reaction chamber, a transition chamber, and an etching ion generation chamber. By moving a sample holder among the injection chamber, the etching reaction chamber and the transition chamber in a scanning direction, a scanning etching is performed on a sample placed on the sample holder, which may realize a large-area, uniform and efficient etching.

Abstract: Disclosed are a water-soluble chlorhexidine antimicrobial agent and a preparation method therefor and use thereof. The present disclosure takes hyaluronic acid as a raw material to prepare a hyaluronic acid aqueous solution or organic solution, then the hyaluronic acid aqueous solution or organic solution and a chlorhexidine solution are subjected to a complexation reaction, an insoluble substance therein is removed, and then the resulting solution is dried to obtain the water-soluble chlorhexidine antimicrobial agent, namely hyaluronic acid chlorhexidine. The hyaluronic acid chlorhexidine has a good broad-spectrum antimicrobial performance, and excellent water solubility.

Abstract: This application is applicable to the field of machine learning technologies and provides a system and a method for target detection. The system includes: a controller and a coprocessor which is in communication connection with the controller. The controller is configured to perform at least some arithmetic operations of a target detection model based on a target image to be detected and/or data sent by the coprocessor. The coprocessor is configured to perform at least some arithmetic operations of the target detection model based on the target image to be detected and/or data sent by the controller. According to the system for target detection, the controller and the coprocessor are utilized to perform some of the arithmetic operations in the target detection model respectively to solve a problem of slow execution speed of target detection task in deployment of the target detection model.

Abstract: A system arrangement and method are provided for allowing the operation of units in a fail safe manner and at low latency. The teachings suggest a specific protocol which allows switching and routing of packages for addressing and controlling light emitting diodes and reading out sensors. The information is distributed according to very specific requirements of the underlying topology and application domain. As light emitting diodes and sensors may affect the reliability of security features in a vehicle specialized approaches have to be provided considering both real-time requirements and reliability. In such a method, a branch device can change its operation mode without an explicit command but, in general, a command may provide an expiry condition of a mode after which the mode returns to its previous mode. Such an expiry condition may be the reception of a predefined number of specific network events.

Abstract: A method is provided to measure a distribution of axial velocities and a flowrate in a pipe or a vessel. The method comprises selecting a single cross-section at a stable-flow segment in a pipe or a vessel, installing a plurality of acoustic wave sensors along a peripheral wall of the pipe or the vessel to form a plurality of effective sound wave paths; measuring sound wave travelling time on each sound wave path; substituting the measured sound wave travelling time data into the model formulas based on a sound path refraction principle for reconstruction calculation to obtain a distribution of axial velocity in the measured cross-section of the pipe or the vessel, u(x,y); and integrating the distribution of the axial velocity u(x,y) along the cross-section to obtain a flow rate. A system is also provided to measure an axial velocity distribution and a flow rate in a pipe.

Abstract: A method of diagnosing and monitoring substance addiction or behavioral addiction, the method including using a biomarker. The biomarker is a biomarker produced by c-Kit gene.

Abstract: A method for prevention and treatment of addictions and control of relapse comprising administering a patient in need thereof a composition comprising imatinib or a derivative thereof, and an addictive substance or an analgesic agent; wherein the addictive substance comprises: (1) narcotic drugs, (2) psychotropic drugs, (3) ethanol, tobacco, volatile organic solvents, and other substances leading to addictions in organisms, and analogues thereof; and (4) nicotine or an analogue thereof.

Abstract: A method is provided to measure a distribution of axial velocities and a flowrate in a pipe or a vessel. The method comprises selecting a single cross-section at a stable-flow segment in a pipe or a vessel, installing a plurality of acoustic wave sensors along a peripheral wall of the pipe or the vessel to form a plurality of effective sound wave paths; measuring sound wave travelling time on each sound wave path; substituting the measured sound wave travelling time data into the model formulas based on a sound path refraction principle for reconstruction calculation to obtain a distribution of axial velocity in the measured cross-section of the pipe or the vessel, u(x,y); and integrating the distribution of the axial velocity u(x,y) along the cross-section to obtain a flow rate. A system is also provided to measure an axial velocity distribution and a flow rate in a pipe.

Abstract: A method is provided to measure a distribution of axial velocities and a flowrate in a pipe or a vessel. The method comprises selecting a single cross-section at a stable-flow segment in a pipe or a vessel, installing a plurality of acoustic wave sensors along a peripheral wall of the pipe or the vessel to form a plurality of effective sound wave paths; measuring sound wave travelling time on each sound wave path; substituting the measured sound wave travelling time into the model formula based on a sound path refraction principle for reconstruction calculation to obtain a distribution of axial velocity in the measured cross-section of the pipe or the vessel, u(x,y); and integrating the distribution of the axial velocity u(x,y) along the cross-section to obtain a flow rate. A system is also provided to measure an axial velocity distribution and a flow rate in a pipe or a vessel.

Abstract: A method is provided to measure a distribution of axial velocities and a flowrate in a pipe or a vessel. The method comprises selecting a single cross-section at a stable-flow segment in a pipe or a vessel, installing a plurality of acoustic wave sensors along a peripheral wall of the pipe or the vessel to form a plurality of effective sound wave paths; measuring sound wave travelling time on each sound wave path; substituting the measured sound wave travelling time into the model formula based on a sound path refraction principle for reconstruction calculation to obtain a distribution of axial velocity in the measured cross-section of the pipe or the vessel, u(x,y); and integrating the distribution of the axial velocity u(x,y) along the cross-section to obtain a flow rate. A system is also provided to measure an axial velocity distribution and a flow rate in a pipe or a vessel.

Abstract: The invention provides a composition and a method for inducing pluripotency in non-pluripotent eukaryotic cells. The composition comprises chemical inducers of pluripotency (CIPs) including glycogen synthase kinase (GSK) inhibitors, TGFp receptor inhibitors, cyclic AMP agonists, S-adenosylhomocysteine hydrolase (SAH) inhibitors, and optionally an agent that promotes histone acetylation. The method comprises contacting a cell with the CIPs for a sufficient period of time to reprogram the cell into a pluripotent stem cell.

Abstract: The invention provides a composition and a method for inducing pluripotency in non-pluripotent eukaryotic cells. The composition comprises chemical inducers of pluripotency (CIPs) including glycogen synthase kinase (GSK) inhibitors, TGFp receptor inhibitors, cyclic AMP agonists, S-adenosylhomocysteine hydrolase (SAH) inhibitors, and optionally an agent that promotes histone acetylation. The method comprises contacting a cell with the CIPs for a sufficient period of time to reprogram the cell into a pluripotent stem cell.