Abstract: Provided herein are compounds, crystalline forms, and pharmaceutical compositions of Compound 1 and/or Compound 2. Also provided are methods of treating a disease or disorder such as a cancer or infectious disease that comprises administering to a subject in need thereof one or more of the compounds or compositions of the present disclosure.

Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12C in a cell, and/or in treating various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (e.g., non-small cell lung cancer).

Abstract: Provided herein are novel heterocyclic compounds, for example, compounds having Formula I. Also provided herein are methods of preparing the compounds and methods of using the same, for example, in inhibiting TGF-beta mediated signaling and/or for treating cancer.

Abstract: The present disclosure provides a method and apparatus for detecting a dose distribution of an article. The method includes performing a fluoroscopy scanning on the article to be detected, to obtain mass data per unit area or unit volume for each point of the article to be detected; obtaining corresponding dose distribution data based on the mass data per unit area or unit volume and a preset mapping model, wherein the preset mapping model includes a mapping relationship between mass per unit area or unit volume and the dose distribution of the article under irradiation of a preset amount of energy; and matching the dose distribution data with a fluoroscopy image of the article to be detected, to generate and display a radiation image.