Abstract: A method of epimerizing an (S)-1-benzylisoquinoline alkaloid to an (R)-1-benzylisoquinoline alkaloid is provided. The method comprises contacting the (S)-1-benzylisoquinoline alkaloid with at least one enzyme. Contacting the (S)-1-benzylisoquinoline alkaloid with the at least one enzyme converts the (S)-1-benzylisoquinoline alkaloid to an (R)-1-benzylisoquinoline alkaloid.

Abstract: The present application relates to a method for measuring the similarity of images/image blocks, which comprises: S1: acquiring two three-dimensional airspace images V and W; S2: decomposing the images V and W to obtain a plurality of sub-bands; S3: calculating a Laplacian probability corresponding to each high-frequency sub-band of V and W, weighting the high-frequency sub-hand; S4: marking two image blocks as X and Y, taking out data blocks corresponding to the image blocks X and Y, and calculating the statistics of the data blocks; S5: calculating the similarities of X and Y in each channel of each sub-band according to the statistics of the data blocks; S6: calculating an average value of the similarities of X and Y in each channel of each sub-band, and taking the average value as the similarity between X and Y.

Abstract: Engineered non-plant cells that produce a benzylisoquinoline alkaloid product that is a derivative of canadine along a metabolic pathway that converts canadine, or an analog of canadine, to a noscapinoid product are provided. Methods of culturing engineered non-plant cells that produce a noscapinoid product and pharmaceutical compositions are also provided.

Abstract: The present application relates to a method for measuring the similarity of images/image blocks, which comprises: S1: acquiring two three-dimensional airspace images V and W; S2: decomposing the images V and W to obtain a plurality of sub-bands; S3: calculating a Laplacian probability corresponding to each high-frequency sub-band of V and W, weighting the high-frequency sub-hand; S4: marking two image blocks as X and Y, taking out data blocks corresponding to the image blocks X and Y, and calculating the statistics of the data blocks; S5: calculating the similarities of X and Yin each channel of each sub-band according to the statistics of the data blocks; S6: calculating an average value of the similarities of X and Y in each channel of each sub-band, and taking the average value as the similarity between X and Y.

Abstract: A method of epimerizing an (S)-1-benzylisoquinoline alkaloid to an (R)-1-benzylisoquinoline alkaloid is provided. The method comprises contacting the (S)-1-benzylisoquinoline alkaloid with at least one enzyme. Contacting the (S)-1-benzyl-isoquinoline alkaloid with the at least one enzyme converts the (S)-1-benzylisoquinoline alkaloid to an (R)-1-benzylisoquinoline alkaloid.

Abstract: Engineered non-plant cells that produce a benzylisoquinoline alkaloid product that is a derivative of canadine along a metabolic pathway that converts canadine, or an analog of canadine, to a noscapinoid product are provided. Methods of culturing engineered non-plant cells that produce a noscapinoid product and pharmaceutical compositions are also provided.