Abstract: A steel ladle drainage method is achieved by using a steel ladle structure. Vacuum interlayers are provided within an upper nozzle, an upper fixed plate, a lower fixed plate and a sliding plate of the steel ladle structure respectively. In the steel ladle drainage method provided by the present invention, a metal drainage agent is used to replace the drainage sand in the prior art, the metal drainage agent is melted by the liquid steel and deposited in the upper nozzle, the sliding plate with the vacuum interlayer and the upper nozzle with the vacuum interlayer have the insulation effect on the melted metal drainage agent. Moreover, through moving the sliding plate, the two pouring holes of the upper and lower fixed plates are connected with each other, the metal drainage agent enters the tundish through the pouring holes and the lower nozzle under the action of gravity.

Abstract: Disclosed herein is a compound of Formula (I) with a Btk inhibitory activity, wherein all the variables are as defined herein. The compound can be used for the treatment of diseases such as autoimmune diseases, xenogeneic immune diseases, cancers or thromboembolic diseases. Also disclosed is a pharmaceutical composition comprising a compound of Formula (I). Further provided is a compound capable of inhibiting the activity of Bruton's tyrosine kinase by covalent binding.