Abstract: An amorphous solid dispersions comprising an active pharmaceutical ingredient and pharmaceutical compositions comprising the amorphous solid dispersions. Also described herein are methods for preparing and using such compositions. In some embodiments, an amorphous solid dispersion comprises an active pharmaceutical ingredient such as palbociclib or neratinib, one or more acids, and a high-molecular weight material.

Abstract: The present disclosure relates to the field of motor vehicles. The teachings thereof may be embodied in a self-locking internal damper comprising: a damper body with a closed chamber; each of two ends of the closed chamber in the length direction including a straight plate section projecting therefrom, with a center line of the straight plate section passing through a center point of the closed chamber; two connecting portions located at ends of the two straight plate sections, respectively; and at least one of the two connecting portions including a bent structure formed by extending and bending one of the straight plate sections.

Abstract: The present disclosure relates to the field of motor vehicles. The teachings thereof may be embodied in a self-locking internal damper comprising: a damper body with a closed chamber; each of two ends of the closed chamber in the length direction including a straight plate section projecting therefrom, with a center line of the straight plate section passing through a center point of the closed chamber; two connecting portions located at ends of the two straight plate sections, respectively; and at least one of the two connecting portions including a bent structure formed by extending and bending one of the straight plate sections.