Abstract: Provided are an SGLT-2 inhibitor-sarcosine cocrystal, a preparation method therefor and use thereof. Using sarcosine as a ligand, said cocrystal has higher safety and lower costs; a drug cocrystal has higher stability, and during the production process or storage process of a formulation composition, the crystal form is not easily changed; said cocrystal does not melt when heated, does not stick, aggregate or generate static electricity, and has better mixing uniformity. Said cocrystal has uniform distribution in a prepared pharmaceutical composition, causing that the pharmaceutical composition has better in-vivo release, absorption and efficacy, and has small difference between batches; and the pharmaceutical composition has high stability, and is more conducive to storage and transportation.

Abstract: A series of tetrahydroisoquinoline derivatives and the crystal forms thereof. Specifically disclosed are a compound as represented by formula (VII), a crystal form thereof, and a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure provides a composite structure, including first and second structure layers which are opposite to each other and adjustment bodies. The first structure layer includes first structure bodies. The second structure layer includes second structure bodies. The first structure bodies and the second structure bodies are staggered. First connecting portions protruding toward the second structure layer are provided at predetermined positions on the first structure bodies where the first structure bodies are staggered relative to the second structure bodies, and second connecting portions protruding toward the first structure layer are provided at predetermined positions on the second structure bodies where the second structure bodies are staggered relative to the first structure bodies, and the first connecting portions and the second connection portions are staggered.

Abstract: Provided are a pressure difference sensor, and a manufacturing method and an application thereof. A manner of bonding three layers of wafers is adopted, and the sensor includes an upper structure, an intermediate structure and a lower structure. Each of the upper structure and the intermediate structure is manufactured by a silicon-on-insulator (SOI) wafer, the lower structure is manufactured by patterned doped intrinsic silicon; and a lead pad of each of the upper electrode, and the intermediate electrode and the lower electrode is located on a corresponding one of three-stepped steps at a side of the pressure difference sensor. Annular through holes are formed around the upper electrode and the lower electrode. A constant capacitance of a capacitance signal outputted by an upper capacitor of the sensor by extending an electric field line path of the constant capacitor part.

Abstract: A self-propelled towing simulator for a hydraulic lift system carries a gyro pose control system and a six-degree-of-freedom (DOF) platform to control the overall pose of the simulator, so that the simulator simulates six-DOF motion states including swaying, surging, yawing, rolling, pitching and heaving generated by a mining vessel under the combined action of waves and flows and required by the experimental working conditions; interventions in the pose of the simulator may be positive or negative, so that the simulator may be applied to the uncontrollable natural water bodies so as to approximate to the working conditions of the experimental requirements. The simulator may carry out experiments in open natural water bodies by use of its own autonomous sailing capability under remote wireless control and may acquire parameters such as dynamic characteristics and spatial configuration and the like of a deep-sea mining hydraulic lift subsystem in real time.

Abstract: The present disclosure provides a wiring structure, a display substrate and a display device, and belongs to the field of display technology. The wiring structure of the present disclosure comprises a body portion provided with hollow patterns; the body portion has a first side and a second side which are provided opposite to each other along an extending direction of the wiring structure, and both the first and second sides are wavy; the body portion comprises a plurality of conductive elements sequentially connected along the extending direction of the wiring structure; and in each conductive element, a length of a protruding portion on the first side in the extending direction of the wiring structure is different from that of a protruding portion on the second side in the extending direction of the wiring structure.

Abstract: Provided are a pressure difference sensor, and a manufacturing method and an application thereof. A manner of bonding three layers of wafers is adopted, and the sensor includes an upper structure, an intermediate structure and a lower structure. Each of the upper structure and the intermediate structure is manufactured by a silicon-on-insulator (SOI) wafer, the lower structure is manufactured by patterned doped intrinsic silicon; and a lead pad of each of the upper electrode, and the intermediate electrode and the lower electrode is located on a corresponding one of three-stepped steps at a side of the pressure difference sensor. Annular through holes are formed around the upper electrode and the lower electrode. A constant capacitance of a capacitance signal outputted by an upper capacitor of the sensor by extending an electric field line path of the constant capacitor part.

Abstract: The present application relates to a method for preparing a pharmaceutical composition, the method comprising providing pharmaceutical compound having a solubility in water of 1 mg/ml or less at 25° C. in a solvent enabling solubilizing the pharmaceutical compound at least partly into the solvent, providing an aqueous dispersion of nanostructured cellulose, and combining the pharmaceutical compound with the aqueous dispersion of nanostructured cellulose in an anti-solvent process to provide nanosized pharmaceutical particles having an average diameter of 50 nm or less, to provide a pharmaceutical composition. The present application also provides pharmaceutical composition, and use of the pharmaceutical composition.

Abstract: The present disclosure provides a wiring structure, a display substrate and a display device, and belongs to the field of display technology. The wiring structure of the present disclosure comprises a body portion provided with hollow patterns; the body portion has a first side and a second side which are provided opposite to each other along an extending direction of the wiring structure, and both the first and second sides are wavy; the body portion comprises a plurality of conductive elements sequentially connected along the extending direction of the wiring structure; and in each conductive element, a length of a protruding portion on the first side in the extending direction of the wiring structure is different from that of a protruding portion on the second side in the extending direction of the wiring structure.

Abstract: Provided is an off-road robot, including a front side portion, a rear side portion and a middle portion. The front side portion includes a front vehicle frame, a front wheel and a first driving system; the front wheels and the first driving system are disposed at the front vehicle frame; and the first driving system drives the front wheels. The rear side portion includes a rear vehicle frame, a rear wheel and a second driving system; the rear wheel and the second driving system are disposed at the rear vehicle frame; and the second driving system drives the rear wheels. The middle portion includes a first frame and a second frame; the first frame and the second frame are detachably connected; the front vehicle frame is connected with the first frame; and the rear vehicle frame is connected with the second frame.

Abstract: Provided are certain PI3K inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: A wearable device includes an annular-shaped wearing member and a first coil. The annular-shaped wearing member includes an outer annular surface, the first coil is accommodated inside the annular-shaped wearing member, and a laying surface of the first coil is arranged along a circumferential direction of the annular-shaped wearing member. An electronic device includes a second coil. In a case that the outer annular surface partially abuts against the electronic device, the first and second coils are disposed opposite to each other, and the first and second coils in an energized state generate magnetic field lines in a same direction. In a wearable system of the embodiments of the present disclosure, the wearable device can be charged while the electronic device is being used, which improves convenience of use of the wearable device.

Abstract: A flexible substrate and a manufacturing method thereof and a display device are provided. The flexible substrate has a bending region. The flexible substrate includes a base substrate, and a first organic layer and a second organic layer which are sequentially laminated on the base substrate, and a surface where the first organic layer contacts the second organic layer in the bending region includes a concave-convex structure.

Abstract: The disclosure provides a back film structure, a method for manufacturing the back film structure, a display panel and a display device. The back film structure is divided into a bending region and a non-bending region. The back film structure includes a thin film layer and a barrier structure on a side of the thin film layer. An orthographic projection of the barrier structure on the thin film layer at least overlaps an orthographic projection of a boundary line between the bending region and the non-bending region on the thin film layer.

Abstract: The present application discloses a display module, a preparation method thereof, and a display apparatus. In a non-display region of the display panel, the display panel and the optical adhesive have a first open pore and a second open pore penetrating through their thickness, respectively; and an orthographic projection of the first open pore falls in an orthographic projection of the second open pore on the cover plate. A light shading part in the light shading region has a third open pore surrounding the light transmitting region; and the light shading part includes a photochromic material in a light shading state, and an orthographic projection of the light shading part on the cover plate at least covers a region, which does not overlap with the orthographic projection of the first open pore on the cover plate, of the orthographic projection of the second open pore on the cover plate.

Abstract: The present application discloses a display module, a preparation method thereof, and a display apparatus. In a non-display region of the display panel, the display panel and the optical adhesive have a first open pore and a second open pore penetrating through their thickness, respectively; and an orthographic projection of the first open pore falls in an orthographic projection of the second open pore on the cover plate. A light shading part in the light shading region has a third open pore surrounding the light transmitting region; and the light shading part includes a photochromic material in a light shading state, and an orthographic projection of the light shading part on the cover plate at least covers a region, which does not overlap with the orthographic projection of the first open pore on the cover plate, of the orthographic projection of the second open pore on the cover plate.

Abstract: The present disclosure provides a wiring structure, a display substrate and a display device, and belongs to the field of display technology. The wiring structure of the present disclosure comprises a body portion provided with hollow patterns; the body portion has a first side and a second side which are provided opposite to each other along an extending direction of the wiring structure, and both the first and second sides are wavy; the body portion comprises a plurality of conductive elements sequentially connected along the extending direction of the wiring structure; and in each conductive element, a length of a protruding portion on the first side in the extending direction of the wiring structure is different from that of a protruding portion on the second side in the extending direction of the wiring structure.

Abstract: A flexible substrate including a flexible base substrate, and a wiring layer and a back film on opposite sides of the flexible base substrate respectively. A side of the flexible base substrate facing away from the wiring layer is provided with a flat area including the back film and a bending area from which the back film is removed, the bending area is provided with an elastic reinforced film, and an elastic modulus of the elastic reinforced film is smaller than an elastic modulus of the back film. A display device including the flexible substrate and a method for manufacturing the flexible substrate are also provided.

Abstract: A manufacturing method and a manufacturing device of a flexible panel are provided. the flexible panel includes a bending area, and the manufacturing method includes: providing a panel unit including a flexible substrate and a back film which are laminated, the panel unit including a panel area corresponding to the flexible panel and a non-panel area outside the panel area; and removing the non-panel area of the panel unit while peeling off a peelable portion of the back film in the bending area of the flexible panel.

Abstract: A flexible display screen includes: a flexible substrate (1); an OLED device layer (2) formed on the flexible substrate (1); an encapsulation layer(3), disposed on the OLED device layer(2) and encapsulating the OLED device layer (2); and an encapsulation protection layer (4) formed on the encapsulation layer (3). The embodiments of the present disclosure also provide a flexible display device and a manufacturing method of the flexible display screen.