Abstract: The present invention provides a method of treating a cancer in an individual using activated T cells or PBMCs induced by antigen presenting cells (such as dendritic cells) loaded with a plurality of tumor antigen peptides. The method may further comprise administration of the antigen presenting cells loaded with the plurality of tumor antigen peptides to the individual. The methods may be used singly or in combination with an immune checkpoint inhibitor. Precision therapy methods customized for the individual using neoantigen peptides or based on the mutation load in the tumor of the individual are provided. Methods of preparing the activated T cells, methods of monitoring the treatment, and methods of cloning tumor-specific T cell receptors are further disclosed. An isolated population of cells comprising the activated T cells, as well as compositions and kits useful for cancer immunotherapy are also provided.

Abstract: The disclosure provides a method, a system and a device for generating test case for automotive cybersecurity detection, which are mainly for regulatory detection of automotive cybersecurity, and applicable to automobile security detection and authentication based on an automotive cybersecurity development flow. The present disclosure constructs an attack vector by splitting an impact parameter of a risk to determine a vector value that contributes most to an automobile risk. The attack vector is dimensionally reduced by principal component analysis, so that the analysis is fast and operable. It constructs a key impact risk of each class by cluster analysis and Chi-square analysis in each class, to form a risk set. An attack path and a test case are constructed based on a risk set, so as to construct test case to be detected.

Abstract: A computer system accesses a storage device. Contents of an object of a request are sorted. The contents of an object of a request are sorted. A hash key is generated to access information in the storage device based on the sorted contents of the object, wherein objects with non-critical differences are mapped to the same hash key. The information in the storage device is accessed based on the generated hash key to produce a response to the request. Embodiments of the present invention further include a method and program product for accessing a storage device in substantially the same manner described above.

Abstract: Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.

Abstract: Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.

Abstract: Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.

Abstract: A computer system processes a group of inputs. A group of entities that is input for processing is intercepted. The intercepted group is expanded into individual entities. Each of the individual entities is processed to produce results for each individual entity. The results for each individual entity are intercepted and merged to produce results for the group of entities. Embodiments of the present invention further include a method and program product for processing a group of inputs in substantially the same manner described above.

Abstract: Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.

Abstract: Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.

Abstract: The present application provides methods of preparing tumor antigen-specific T cells comprising enriching activated T cells from a first co-culture comprising a first population of antigen-loaded dendritic cells loaded and a population of T cells, and co-culturing the enriched activated T cells with a second population of antigen-loaded dendritic cells. Also provided are methods of treating cancer in an individual using the tumor antigen-specific T cells, pharmaceutical compositions and kits for cell-based cancer immunotherapy.

Abstract: The present invention provides methods of preparing a population of activated T cells by co-culturing T cells with dendritic cells loaded with a plurality of tumor antigen peptides. Also provided are methods of treating cancer in an individual using the activated T cells, pharmaceutical compositions and kits for cell-based cancer immunotherapy.

Abstract: Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.

Abstract: Network entities may indicate and negotiate one or more new protocols for communications using a current protocol. Indications may include one or more protocols which are supported, one or more protocols which are preferred, and the level of desire of preferences. Indications may further include schedules of times during which certain protocols are supported and/or schedules of functions for which certain protocols are preferred. Indications may be evaluated and acted upon immediately or stored for future reference. Evaluation may include comparison of relative desire levels and needs of various entities. Protocols may be messaging protocols, transport protocols, or combinations thereof.

Abstract: The present invention provides a method of treating a cancer in an individual using activated T cells or PBMCs induced by antigen presenting cells (such as dendritic cells) loaded with a plurality of tumor antigen peptides. The method may further comprise administration of the antigen presenting cells loaded with the plurality of tumor antigen peptides to the individual. The methods may be used singly or in combination with an immune checkpoint inhibitor. Precision therapy methods customized for the individual using neoantigen peptides or based on the mutation load in the tumor of the individual are provided. Methods of preparing the activated T cells, methods of monitoring the treatment, and methods of cloning tumor-specific T cell receptors are further disclosed. An isolated population of cells comprising the activated T cells, as well as compositions and kits useful for cancer immunotherapy are also provided.

Abstract: The present application provides methods of preparing tumor antigen-specific T cells comprising enriching activated T cells from a first co-culture comprising a first population of antigen-loaded dendritic cells loaded and a population of T cells, and co-culturing the enriched activated T cells with a second population of antigen-loaded dendritic cells. Also provided are methods of treating cancer in an individual using the tumor antigen-specific T cells, pharmaceutical compositions and kits for cell-based cancer immunotherapy.

Abstract: The present invention provides methods of preparing a population of activated T cells by co-culturing T cells with dendritic cells loaded with a plurality of tumor antigen peptides. Also provided are methods of treating cancer in an individual using the activated T cells, pharmaceutical compositions and kits for cell-based cancer immunotherapy.

Abstract: According to embodiments of the present invention, similarity metrics or measures of similarity may be combined using an adaptive weighting scheme. A subset of entities from a first set of entities that have a known relationship is randomly selected. The subset is combined with a second set of entities that have an unknown relationship to each other and/or to the first set of entities. At least two different measures of similarity (similarity metrics) between the first set and the combined second set (including the subset) is determined for each entity in the second set. For each entity in the second set, the at least two different measures of similarity are compared, and a weight is assigned adaptively to each measure of similarity based on the magnitude of the measure of similarity. The weighted measures of similarity are combined to determine an aggregate adaptively weighted similarity score for each entity.

Abstract: According to embodiments of the present invention, similarity metrics or measures of similarity may be combined using an adaptive weighting scheme. A subset of entities from a first set of entities that have a known relationship is randomly selected. The subset is combined with a second set of entities that have an unknown relationship to each other and/or to the first set of entities. At least two different measures of similarity (similarity metrics) between the first set and the combined second set (including the subset) is determined for each entity in the second set. For each entity in the second set, the at least two different measures of similarity are compared, and a weight is assigned adaptively to each measure of similarity based on the magnitude of the measure of similarity. The weighted measures of similarity are combined to determine an aggregate adaptively weighted similarity score for each entity.

Abstract: Provided is a method of treating a cancer in an individual using activated T cells or PBMCs induced by antigen presenting cells (such as dendritic cells) loaded with a plurality of tumor antigen peptides. The method may further comprise administration of the antigen presenting cells loaded with the plurality of tumor antigen peptides to the individual. The methods may be used singly or in combination with an immune checkpoint inhibitor. Also provided are precision therapy methods customized for the individual using neoantigen peptides or based on the mutation load in the tumor of the individual, methods of preparing the activated T cells, methods of monitoring the treatment, methods of cloning tumor-specific T cell receptors, an isolated population of cells comprising the activated T cells, and compositions and kits useful for cancer immunotherapy.

Abstract: Provided is a method of treating a cancer in an individual using activated T cells or PBMCs induced by antigen presenting cells (such as dendritic cells) loaded with a plurality of tumor antigen peptides. The method may further comprise administration of the antigen presenting cells loaded with the plurality of tumor antigen peptides to the individual. The methods may be used singly or in combination with an immune checkpoint inhibitor. Also provided are precision therapy methods customized for the individual using neoantigen peptides or based on the mutation load in the tumor of the individual, methods of preparing the activated T cells, methods of monitoring the treatment, methods of cloning tumor-specific T cell receptors, an isolated population of cells comprising the activated T cells, and compositions and kits useful for cancer immunotherapy.