Abstract: This invention relates generally to neurodegenerative diseases and conditions (e.g., Alzheimer's disease) characterized with dysfunctional energetic function, unregulated microglia phagocytic activity and other related de-regulated biological functions. This invention further relates to methods and compositions for treating such neurodegenerative diseases and conditions with pharmaceutical compositions comprising one or more of agents capable of protecting neurons from cell death and unregulated microglia phagocytic activity.

Abstract: This invention is in the field of medicinal pharmacology. In particular, the present invention relates to pharmaceutical agents which function as inhibitors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral replication and/or SARS-CoV-2 related viral 3CL protease (Mpro) activity, which function as therapeutics for the treatment of conditions caused by the SARS-CoV-2 virus (e.g., COVID-19), and which function as therapeutics for the treatment conditions related to SARS-CoV-2 related Mpro activity.

Abstract: A backside illuminated CMOS image sensor and a method of fabricating the sensor are disclosed. The backside illuminated CMOS image sensor includes a first substrate and a second substrate. A plurality of pixel cells are formed in the front side of the first substrate, and a plurality of grooves are formed in the back side. Each of the grooves has at least one sidewall inclined with respect to the back surface of the first substrate. The second substrate is bonded to the first substrate on a side closer to the front side. A method for fabricating such a backside illuminated CMOS image sensor is also disclosed. The grooves formed in the back side of the first substrate can reduce reflection loss of light incident on the back surface and hence enhance quantum efficiency of the backside illuminated CMOS image sensor.

Abstract: A searching method and a searching apparatus are provided. The method includes: obtaining a search term input from a client device; determining a type of the search term, and obtaining a knowledge graph corresponding to the type of the search term; and returning the knowledge graph corresponding to the type of the search term to the client device, such that the client device displays information contained in the knowledge graph in a structured form.

Abstract: A searching method and a searching apparatus are provided. The method includes: obtaining a search term input from a client device; determining a type of the search term, and obtaining a knowledge graph corresponding to the type of the search term; and returning the knowledge graph corresponding to the type of the search term to the client device, such that the client device displays information contained in the knowledge graph in a structured form.