Abstract: The present invention provides compounds which are selective kappa-opioid receptor agonist, method of preparation of these compounds, compositions that comprise these compounds, and methods for treating kappa-opiod receptor agonist related medical disorders.

Abstract: The present disclosure is directed to monitoring internal process memory of a computer at a time with program code executes. Methods and apparatus consistent with the present disclosure monitor the operation of program code with the intent of detecting whether received program inputs may exploit vulnerabilities that may exist in the program code at runtime. By detecting suspicious activity or malicious code that may affect internal process memory at run-time, methods and apparatus described herein identify suspected malware based on suspicious actions performed as program code executes. Runtime exploit detection may detect certain anomalous activities or chain of events in a potentially vulnerable application during execution. These events may be detected using instrumentation code when a regular code execution path of an application is deviated from.

Abstract: The present invention discloses a multi-tier wave-filter and an on-board power source DCDC conversion device. The multi-tier wave-filter includes: N-tiered PCB boards arranged at intervals, wherein N is greater than or equal to 3; N?1-level output inductors arranged at intervals, wherein an output inductor at each level is connected to adjacent upper-tier and lower-tier PCB boards through its input end and output end, respectively; N?1-level output capacitors arranged at intervals, wherein an output capacitor at each level is correspondingly connected to PCB boards between a second tier and a Nth tier, respectively; and a filter output terminal connected to an output end of the N?1-level output inductor. The multi-tier wave-filter provided by the present invention not only achieves miniaturizing the wave-filter and decreasing installation space, but also better enables the high-current path at the output end of the DCDC converter to have heat dissipation, filtering, shielding and other properties.

Abstract: The present invention discloses a novel class of monoacylglycerol lipase (MAGL) small molecule inhibitors, as well as pharmaceutical compositions, preparation methods, and uses thereof. The MAGL small molecule inhibitors are represented by formula (I), with specific substituents and definitions as described in the specification. The disclosed MAGL small molecule inhibitors exhibit excellent MAGL enzyme inhibitory activity. The invention includes these compounds or their pharmaceutical compositions for the treatment and/or prevention of MAGL-related conditions such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury, neurotoxicity, stroke, epilepsy, anxiety, migraine, depression, hepatocellular carcinoma, colorectal cancer lesions, ovarian cancer, neuropathic pain, chemotherapy-induced neuropathy, acute pain, chronic pain, and/or pain-associated spasticity.

Abstract: The disclosure provides a quick-disassembly device, comprising a connector, a carrier and a limiting assembly. The carrier is provided with an accommodating cavity and a limiting cavity; the connector is movably arranged with the carrier relatively, in an entering state, the connector is at least partially accommodated in the accommodating cavity, and in a locking state, the connector is at least partially accommodated in the limiting cavity and relatively fixed with the carrier; the limiting assembly comprises a first connecting block and a second connecting block, and in the locking state, the connector is abutted against an inner wall of the limiting cavity under a magnetic force between the first connecting block and the second connecting block, and is fixed in the limiting cavity.

Abstract: The present disclosure is directed to monitoring internal process memory of a computer at a time with program code executes. Methods and apparatus consistent with the present disclosure monitor the operation of program code with the intent of detecting whether received program inputs may exploit vulnerabilities that may exist in the program code at runtime. By detecting suspicious activity or malicious code that may affect internal process memory at run-time, methods and apparatus described herein identify suspected malware based on suspicious actions performed as program code executes. Runtime exploit detection may detect certain anomalous activities or chain of events in a potentially vulnerable application during execution. These events may be detected using instrumentation code when a regular code execution path of an application is deviated from.

Abstract: The present disclosure is directed to a class of Sigma-1 receptor small molecule antagonists, their pharmaceutical compositions, preparation methods, and uses. The Sigma-1 receptor small molecule antagonists are shown in formula (I), with specific substituents and definitions described in the specification. These Sigma-1 receptor small molecule antagonists exhibit good binding and antagonistic activity with the Sigma-1 receptor. The invention includes these compounds or their pharmaceutical compositions and their use in treating and/or preventing pain disorders related to the Sigma-1 receptor.

Abstract: The present disclosure relates to the technical field of drug synthesis, and provides a method for preparing a key intermediate of ABT-737 and a method for preparing ABT-737. In the present disclosure, the compound having a structure represented by formula I is used as the starting material. The carboxyl group in the compound having a structure represented by formula I is first reduced to a hydroxyl group, followed by a vulcanization by a vulcanizing agent, and then an amination, a deprotection, a condensation, and a carbonyl group reduction, to obtain the key intermediate of ABT-737 having a structure represented by formula VI. Tert-butoxycarbonyl is used as the protecting group for the compound having a structure represented by formula I, and the subsequent intermediate containing the protecting group of tert-butoxycarbonyl is stable, and easy to be deprotected. This method is suitable for mass synthesis, with high product yield and low production cost, and thus has a good industrialization prospect.

Abstract: The present disclosure is directed to monitoring internal process memory of a computer at a time with program code executes. Methods and apparatus consistent with the present disclosure monitor the operation of program code with the intent of detecting whether received program inputs may exploit vulnerabilities that may exist in the program code at runtime. By detecting suspicious activity or malicious code that may affect internal process memory at run-time, methods and apparatus described herein identify suspected malware based on suspicious actions performed as program code executes. Runtime exploit detection may detect certain anomalous activities or chain of events in a potentially vulnerable application during execution. These events may be detected using instrumentation code when a regular code execution path of an application is deviated from.

Abstract: The present disclosure is directed to monitoring internal process memory of a computer at a time with program code executes. Methods and apparatus consistent with the present disclosure monitor the operation of program code with the intent of detecting whether received program inputs may exploit vulnerabilities that may exist in the program code at runtime. By detecting suspicious activity or malicious code that may affect internal process memory at run-time, methods and apparatus described herein identify suspected malware based on suspicious actions performed as program code executes. Runtime exploit detection may detect certain anomalous activities or chain of events in a potentially vulnerable application during execution. These events may be detected using instrumentation code when a regular code execution path of an application is deviated from.

Abstract: The present invention provides compounds which are selective kappa-opioid receptor agonist, method of preparation of these compounds, compositions that comprise these compounds, and methods for treating kappa-opiod receptor agonist related medical disorders.

Abstract: The present disclosure is directed to monitoring internal process memory of a computer at a time with program code executes. Methods and apparatus consistent with the present disclosure monitor the operation of program code with the intent of detecting whether received program inputs may exploit vulnerabilities that may exist in the program code at runtime. By detecting suspicious activity or malicious code that may affect internal process memory at run-time, methods and apparatus described herein identify suspected malware based on suspicious actions performed as program code executes. Runtime exploit detection may detect certain anomalous activities or chain of events in a potentially vulnerable application during execution. These events may be detected using instrumentation code when a regular code execution path of an application is deviated from.

Abstract: The present disclosure is directed to monitoring internal process memory of a computer at a time with program code executes. Methods and apparatus consistent with the present disclosure monitor the operation of program code with the intent of detecting whether received program inputs may exploit vulnerabilities that may exist in the program code at runtime. By detecting suspicious activity or malicious code that may affect internal process memory at run-time, methods and apparatus described herein identify suspected malware based on suspicious actions performed as program code executes. Runtime exploit detection may detect certain anomalous activities or chain of events in a potentially vulnerable application during execution. These events may be detected using instrumentation code when a regular code execution path of an application is deviated from.

Abstract: The present disclosure is directed to monitoring internal process memory of a computer at a time with program code executes. Methods and apparatus consistent with the present disclosure monitor the operation of program code with the intent of detecting whether received program inputs may exploit vulnerabilities that may exist in the program code at runtime. By detecting suspicious activity or malicious code that may affect internal process memory at run-time, methods and apparatus described herein identify suspected malware based on suspicious actions performed as program code executes. Runtime exploit detection may detect certain anomalous activities or chain of events in a potentially vulnerable application during execution. These events may be detected using instrumentation code when a regular code execution path of an application is deviated from.

Abstract: A charge wake-up circuit for a battery management system (“BMS”) for an electric vehicle, the circuit including a charging plug connection circuit, a comparator circuit, and a DC wake-up circuit. The charge wake-up circuit monitors the state of the charger after the BMS turns off. If the charger charges the battery pack after the BMS turns off, the BMS will be started by the charge wake-up circuit and continue to monitor the battery pack. If the charger is off-line, the BMS will maintain the low-power state to prevent the automotive lead-acid battery from over-discharging.

Abstract: A charge wake-up circuit for Battery Management System (BMS). The circuit includes the charge-discharge module and charge detection module. The charge-discharge module contains Charger W, load R1, first switch K1, second switch K2, battery E, charge MOSFET M1 and discharge MOSFET M2. The charge detection module contains inductance L 1, first diode D1, second diode D2, first resistor R2, second resistor R3, third resistor R4, fourth resistor R5, fifth resistor R6, sixth resistor R7, seventh resistor RS, first capacitor C1, second capacitor C2, third capacitor C3, first transistor Q1, second transistor Q2 and photocoupler U.

Abstract: The present disclosure relates to a method and a device for running an application program. The method includes: receiving a triggering signal instructing to run a second application program in a operating first application program; loading and parsing an installation package of the second application program to obtain a program component of the second application program through the first application program; and running the program component of the second application program in a runtime environment provided by the first application program.

Abstract: This invention involves a battery short-circuit protection circuit installed in a battery-load circuit. In the battery-load circuit, there is a battery and a load RL. The battery and RL form a circuit. The two ends of the battery are positive discharge end P+ and negative discharge end P?, respectively. The battery short-circuit protection circuit is in series with the battery-load circuit. The battery short-circuit protection circuit includes a charge-discharge circuit, a current amplifier circuit, and a current comparator circuit. The charge-discharge circuit includes MOS transistors and a sampling resistor. The current amplifier circuit includes a signal conditioning circuit and a current amplifier. The current comparator circuit includes a current comparator, a current reference circuit for short-circuit protection consisting, a MOS transistor, a diode, a resistor, and an optronics relay.

Abstract: Method, device and computer-readable medium for enabling a virtual Subscriber Identity Module (SIM) card are provided in the disclosure, which belongs to a technical field of communication. The method includes: receiving an initiation instruction for initiating the virtual SIM card; detecting a current talk mode of a communication device based on the initiation instruction, the current talk mode includes a single-card mode; and installing a target talk mode corresponding to the current talk mode according to the current talk mode, the target talk mode includes a dual-card mode. The method and device for enabling a virtual SIM card may solve the problem that the virtual SIM card may not coexist with a physical SIM card in a single-card mode communication device, and may achieve an effect that the virtual SIM card and the physical SIM card may coexist with each other.