Patents by Inventor Yao-Kuang CHUNG
Yao-Kuang CHUNG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12099011Abstract: The present invention relates to a fluorescent polymer cast on the surface of wells of a plate and a plate comprising the fluorescent polymer. The plate is used in a method for calibrating read-out values of plate readers. The method for calibrating the plate readers can effectively reduce the deviation of read-out values among different plate readers.Type: GrantFiled: October 28, 2020Date of Patent: September 24, 2024Assignee: PLEXBIO CO., LTD.Inventors: Cheng-Tse Lin, Yi-Ming Sun, Kuei-Shen Hsu, Liang-Han Chang, Yao-Kuang Chung, Chin-Yun Wu, Chin-Shiou Huang
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Patent number: 11796535Abstract: Disclosed herein are compositions comprising beads with unique analog code identifiers for storing information about a multiplex assay as well as methods for using the same in multiplex chemical and biological assays.Type: GrantFiled: November 21, 2016Date of Patent: October 24, 2023Assignee: Plexbio Co., Ltd.Inventors: Dean Tsao, Chin-Shiou Huang, Yao-Kuang Chung
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Patent number: 11579522Abstract: Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarriers are encoded with an analog code for identification and include a capture agent for analyte detection. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits for conducting a multiplex assay using the microcarriers described herein.Type: GrantFiled: April 16, 2019Date of Patent: February 14, 2023Assignee: PLEXBIO CO., LTD.Inventors: Dean Tsao, Chin-Shiou Huang, Yao-Kuang Chung
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Publication number: 20210041362Abstract: The present invention relates to a fluorescent polymer cast on the surface of wells of a plate and a plate comprising the fluorescent polymer. The plate is used in a method for calibrating read-out values of plate readers. The method for calibrating the plate readers can effectively reduce the deviation of read-out values among different plate readers.Type: ApplicationFiled: October 28, 2020Publication date: February 11, 2021Inventors: Cheng-Tse LIN, Yi-Ming SUN, Kuei-Shen HSU, Liang-Han CHANG, Yao-Kuang CHUNG, Chin-Yun WU, Chin-Shiou HUANG
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Patent number: 10913070Abstract: A microarray carrier assembly including a scan tray and a plurality of microarray blocks detachably disposed on the scan tray is provided. The scan tray includes a frame including an opening and a slot, and a transparent substrate covering the opening of the frame. Each of the microarray blocks includes a main body, a probe array distributed on the main body and facing towards the transparent substrate of the scan tray, and a plurality of guiding pins disposed on the main body and surrounding the probe array, wherein a top surface area of the guiding pin opposite to the main body is less than a bottom surface area of the guiding pin connected to the main body, and the guiding pins are detachably inserted into the slot of the frame of the scan tray.Type: GrantFiled: May 31, 2018Date of Patent: February 9, 2021Assignee: Centrillion Technologies Taiwan Co. LTD.Inventors: Wei Zhou, Lin-Hsin Tu, Yao-Kuang Chung, Tzu-Kun Ku, Glenn McGall
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Patent number: 10872924Abstract: A microarray and a method for forming the same are disclosed and the method includes the following steps. A solid matrix and a micro LED array is provided, wherein the solid matrix comprises a plurality of areas corresponding to a plurality of LEDs of the micro LED array. A monomer with a photolabile protecting group is formed in the plurality of areas respectively. At least one of the plurality of areas is irradiated by turning on the corresponding LED of the micro LED array, so as to eliminate the photolabile protecting group of the monomer in the at least one of the plurality of areas. A monomer is conjugated to the deprotected monomer in the at least one of the plurality of areas. The steps of irradiating and conjugating are repeated, so as to form probes in the plurality of areas respectively.Type: GrantFiled: November 27, 2018Date of Patent: December 22, 2020Assignee: Centrillion Technologies Taiwan Co. LTD.Inventors: Tzu-Kun Ku, Yao-Kuang Chung, Chun-Hao Chang
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Patent number: 10859910Abstract: Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarriers are encoded with an analog code for identification and include a capture agent for analyte detection. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits for conducting a multiplex assay using the microcarriers described herein.Type: GrantFiled: April 16, 2019Date of Patent: December 8, 2020Assignee: PLEXBIO CO., LTD.Inventors: Dean Tsao, Chin-Shiou Huang, Yao-Kuang Chung
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Patent number: 10852237Abstract: A microarray including a plurality of detection areas and at least one mark is provided. The plurality of the detection areas are arranged in an array. The at least one mark is disposed among or beside the plurality of the detection areas. The at least one mark is configured for at least one of image focusing, positioning and splicing, wherein the at least one mark comprises a plurality of grid dots distributed in an area. The area comprises a plurality of zones arranged in an array, each of the plurality of the grid dots is disposed in one of the plurality of the zones, a number of the plurality of the grid dots is less than a number of the plurality of the zones, and the plurality of the grid dots form a two-dimensional pattern.Type: GrantFiled: March 19, 2019Date of Patent: December 1, 2020Assignee: Centrillion Technologies Taiwan Co., LTD.Inventors: Yao-Kuang Chung, Jui-Hung Hung, Chao-Hsi Lee
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Patent number: 10732166Abstract: A method for in-line measurement of the quality of a microarray are disclosed and the method includes the following steps. A solid substrate is provided, and the solid substrate includes a plurality of areas in an array. At least one biomarker is in-situ synthesized on at least one of the plurality of areas by a plurality of synthesis steps. After performing at least one of the plurality of synthesis step, a check step is immediately performed on a semi-product of the at least one biomarker by an atomic force microscope to obtain an in-line measurement result. The quality of the semi-product of the at least one biomarker is determined based on the in-line measurement result.Type: GrantFiled: February 14, 2018Date of Patent: August 4, 2020Assignee: Centrillion Technologies Taiwan Co. LTD.Inventors: Tzu-Kun Ku, Yao-Kuang Chung, Yu-Chen Wang, Po-Yen Liu
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Publication number: 20190369091Abstract: Disclosed herein are compositions comprising beads with unique analog code identifiers for storing information about a multiplex assay as well as methods for using the same in multiplex chemical and biological assays.Type: ApplicationFiled: November 21, 2016Publication date: December 5, 2019Applicant: Plexbio Co., Ltd.Inventors: Dean TSAO, Chin-Shiou HUANG, Yao-Kuang CHUNG
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Patent number: 10436776Abstract: Provided herein are methods, systems, devices, and computer-readable storage media for selecting a detection area for a well (e.g., as part of an assay plate) comprising a plurality of encoded microcarriers. In some aspects, selecting the detection area includes obtaining one or more images of the well; calculating a center of the well according to a two-dimensional coordinate system; assigning a position, according to the two-dimensional coordinate system, of a first encoded microcarrier from the plurality; determining whether a distance between the position of the first encoded microcarrier and the center of the well according to the two-dimensional coordinate system exceeds a threshold distance; and including in the detection area one or more microcarriers whose distance from the center of the well does not exceed the threshold distance, while excluding those whose distance from the center of the well exceeds the threshold.Type: GrantFiled: November 21, 2016Date of Patent: October 8, 2019Assignee: PLEXBIO CO., LTD.Inventors: Yao-Kuang Chung, Chia-En Tai, Liang Han Chang
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Publication number: 20190293563Abstract: A microarray including a plurality of detection areas and at least one mark is provided. The plurality of the detection areas are arranged in an array. The at least one mark is disposed among or beside the plurality of the detection areas. The at least one mark is configured for at least one of image focusing, positioning and splicing, wherein the at least one mark comprises a plurality of grid dots distributed in an area. The area comprises a plurality of zones arranged in an array, each of the plurality of the grid dots is disposed in one of the plurality of the zones, a number of the plurality of the grid dots is less than a number of the plurality of the zones, and the plurality of the grid dots form a two-dimensional pattern.Type: ApplicationFiled: March 19, 2019Publication date: September 26, 2019Applicant: Centrillion Technologies Taiwan Co. LTD.Inventors: Yao-Kuang Chung, Jui-Hung Hung, Chao-Hsi Lee
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Publication number: 20190265567Abstract: Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarriers are encoded with an analog code for identification and include a capture agent for analyte detection. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits for conducting a multiplex assay using the microcarriers described herein.Type: ApplicationFiled: April 16, 2019Publication date: August 29, 2019Inventors: Dean TSAO, Chin-Shiou HUANG, Yao-Kuang CHUNG
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Publication number: 20190242884Abstract: Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarriers are encoded with an analog code for identification and include a capture agent for analyte detection. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits for conducting a multiplex assay using the microcarriers described herein.Type: ApplicationFiled: April 16, 2019Publication date: August 8, 2019Inventors: Dean TSAO, Chin-Shiou HUANG, Yao-Kuang CHUNG
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Publication number: 20190165039Abstract: A microarray and a method for forming the same are disclosed and the method includes the following steps. A solid matrix and a micro LED array is provided, wherein the solid matrix comprises a plurality of areas corresponding to a plurality of LEDs of the micro LED array. A monomer with a photolabile protecting group is formed in the plurality of areas respectively. At least one of the plurality of areas is irradiated by turning on the corresponding LED of the micro LED array, so as to eliminate the photolabile protecting group of the monomer in the at least one of the plurality of areas. A monomer is conjugated to the deprotected monomer in the at least one of the plurality of areas. The steps of irradiating and conjugating are repeated, so as to form probes in the plurality of areas respectively.Type: ApplicationFiled: November 27, 2018Publication date: May 30, 2019Applicant: Centrillion Technologies Taiwan Co. LTD.Inventors: Tzu-Kun Ku, Yao-Kuang Chung, Chun-Hao Chang
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Patent number: 10302640Abstract: Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarriers are encoded with an analog code for identification and include a capture agent for analyte detection. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits for conducting a multiplex assay using the microcarriers described herein.Type: GrantFiled: December 9, 2016Date of Patent: May 28, 2019Assignee: PLEXBIO CO., LTD.Inventors: Dean Tsao, Chin-Shiou Huang, Yao-Kuang Chung
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Publication number: 20180345290Abstract: A microarray carrier assembly including a scan tray and a plurality of microarray blocks detachably disposed on the scan tray is provided. The scan tray includes a frame including an opening and a slot, and a transparent substrate covering the opening of the frame. Each of the microarray blocks includes a main body, a probe array distributed on the main body and facing towards the transparent substrate of the scan tray, and a plurality of guiding pins disposed on the main body and surrounding the probe array, wherein a top surface area of the guiding pin opposite to the main body is less than a bottom surface area of the guiding pin connected to the main body, and the guiding pins are detachably inserted into the slot of the frame of the scan tray.Type: ApplicationFiled: May 31, 2018Publication date: December 6, 2018Applicant: Centrillion Technologies Taiwan Co. LTD.Inventors: Wei Zhou, Lin-Hsin Tu, Yao-Kuang Chung, Tzu-Kun Ku, Glenn McGall
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Publication number: 20180238855Abstract: A method for in-line measurement of the quality of a microarray are disclosed and the method includes the following steps. A solid substrate is provided, and the solid substrate includes a plurality of areas in an array. At least one biomarker is in-situ synthesized on at least one of the plurality of areas by a plurality of synthesis steps. After performing at least one of the plurality of synthesis step, a check step is immediately performed on a semi-product of the at least one biomarker by an atomic force microscope to obtain an in-line measurement result. The quality of the semi-product of the at least one biomarker is determined based on the in-line measurement result.Type: ApplicationFiled: February 14, 2018Publication date: August 23, 2018Applicant: Centrillion Technologies Taiwan Co. LTD.Inventors: Tzu-Kun Ku, Yao-Kuang Chung, Yu-Chen Wang, Po-Yen Liu
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Patent number: 10019815Abstract: Provided herein are methods, systems, devices, and computer-readable storage media for measuring flatness (e.g., along a Z-axis) of a detection stage. In some aspects, measuring flatness of the detection stage includes obtaining two or more images representing different Z coordinates of a first XY coordinate on a substantially flat substrate positioned on the detection stage; determining a sharpest Z coordinate at the first XY coordinate based on sharpness of the two or more images; obtaining two or more images representing different Z coordinates of a second XY coordinate spaced apart from the first XY coordinate on the substantially flat substrate; determining a sharpest Z coordinate at the second XY coordinate based on sharpness of the two or more images; and calculating a difference between the sharpest Z coordinates at the first and the second XY coordinates to measure the flatness of the detection stage.Type: GrantFiled: March 16, 2017Date of Patent: July 10, 2018Assignee: PLEXBIO CO., LTD.Inventors: Yao-Kuang Chung, Chia-En Tai, Chien Teng Kao
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Publication number: 20170284942Abstract: The present invention relates to a fluorescent polymer cast on the surface of wells of a plate and a plate comprising the fluorescent polymer. The plate is used in a method for calibrating read-out values of plate readers. The method for calibrating the plate readers can effectively reduce the deviation of read-out values among different plate readers.Type: ApplicationFiled: March 27, 2017Publication date: October 5, 2017Inventors: Cheng-Tse LIN, Yi-Ming SUN, Kuei-Shen HSU, Liang-Han CHANG, Yao-Kuang CHUNG, Chin-Yun WU, Chin-Shiou HUANG