Patents by Inventor Yao-Ming Huang

Yao-Ming Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10365829
    Abstract: A memory transaction-level modeling method and a memory transaction-level modeling system are provided. The memory transaction-level modeling method is used for simulating the operation of outputting at least one command to the memory. The memory includes a plurality of banks each of which corresponds with a bank status table. The memory transaction-level modeling method includes the following steps: An event is received. Whether one of the bank status tables is needed to be updated is determined. If one of the bank status tables is needed to be updated, this bank status table is recovered according to a TMP queue. A command is outputted to the memory according to a command queue. The outputted command is stored in the TMP queue. Some of the bank status tables are updated and others of the bank status tables are kept unchanged.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: July 30, 2019
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Yao-Hua Chen, Che-Wei Hsu, Juin-Ming Lu, Wei-Shiang Lin, Jing-Jia Liou, Chih-Tsun Huang
  • Publication number: 20190148442
    Abstract: Some embodiments of the present disclosure provide a back side illuminated (BSI) image sensor. The back side illuminated (BSI) image sensor includes a semiconductive substrate and an interlayer dielectric (ILD) layer at a front side of the semiconductive substrate. The ILD layer includes a dielectric layer over the semiconductive substrate and a contact partially buried inside the semiconductive substrate. The contact includes a silicide layer including a predetermined thickness proximately in a range from about 600 angstroms to about 1200 angstroms.
    Type: Application
    Filed: December 18, 2018
    Publication date: May 16, 2019
    Inventors: CHIH-CHANG HUANG, CHI-MING LU, JIAN-MING CHEN, JUNG-CHIH TSAO, YAO-HSIANG LIANG
  • Publication number: 20190085369
    Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
    Type: Application
    Filed: April 16, 2018
    Publication date: March 21, 2019
    Applicants: Biogen MA Inc., Samsung Bioepis
    Inventors: William C. Yang, Yao-Ming Huang, Kyle McElearney, Lia Tescione, James Lambropoulos, An Zhang, Valerie Liu Tsang, Thomas Ryll, Sangil Lee, Dae Sung Lee
  • Patent number: 9944968
    Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: April 17, 2018
    Assignees: Biogen MA Inc., Samsung Bioepis
    Inventors: William Yang, Yao-Ming Huang, Kyle McElearney, Lia Tescione, James Lambropoulos, An Zhang, Valerie Tsang, Thomas Ryll, Sangil Lee, Dae Sung Lee
  • Publication number: 20170327786
    Abstract: The present invention pertains to a cell culture medium comprising hypotaurine, GABA, and/or beta-alanine or the combination of choline and hypotaurine, GABA, and/or beta-alanine as media supplements which is shown to control viability, growth, and waste byproduct accumulation. The present invention further pertains to a method of producing a polypeptide of interest in a large scale cell culture containing hypotaurine, GABA, and/or beta-alanine or the combination of choline and hypotaurine, GABA, and/or beta-alanine.
    Type: Application
    Filed: October 30, 2015
    Publication date: November 16, 2017
    Applicant: Biogen MA Inc.
    Inventors: Yao-Ming HUANG, William C. YANG, Alan GILBERT, Kyle MCELEARNEY
  • Publication number: 20170175075
    Abstract: The present invention pertains to methods of producing polypeptide of interest in cell cultures lacking glutamine. The present invention further pertains to a method of producing a protein of interest in a large scale cell culture, comprising supplementing the cell culture with nucleic acid synthesis precursors and/or corticosteroids.
    Type: Application
    Filed: March 24, 2015
    Publication date: June 22, 2017
    Applicants: Biogen MA Inc., Samsung Bioepis
    Inventors: William YANG, Yao-Ming HUANG, Marty SINACORE, Thomas RYLL, Jiuyi LU, Jaesun LEE, Kyngju LEE, Hyoung Taek LIM, Eunchong YANG
  • Publication number: 20160304928
    Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
    Type: Application
    Filed: January 19, 2016
    Publication date: October 20, 2016
    Applicant: Biogen MA Inc.
    Inventors: William YANG, Yao-Ming Huang, Kyle McElearney, Lia Tescione, James Lambropoulos, An Zhang, Valerie Tsang, Thomas Ryll
  • Publication number: 20160289633
    Abstract: Methods of improving the efficiency of production of a protein product of interest in mammalian cell culture are presented. In particular, the methods result in an increase in the quantity of a protein product produced, or decreases protein product production time in a manufacturing-scale bioreactor cell culture. The disclosed methods comprise: (a) culturing the N-1 bioreactor culture to high viable cell densities; and (b) seeding the production bioreactor culture at high viable cell seeding densities.
    Type: Application
    Filed: December 19, 2014
    Publication date: October 6, 2016
    Applicant: Biogen MA Inc.
    Inventors: William C. YANG, Jiuyi LU, Yao-Ming HUANG, Hang YUAN, Rashmi KSHIRSAGAR, Thomas RYLL
  • Publication number: 20160237399
    Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
    Type: Application
    Filed: February 18, 2015
    Publication date: August 18, 2016
    Applicant: Biogen MA Inc.
    Inventors: William YANG, Yao-Ming Huang, Kyle McElearney, Lia Tescione, James Lambropoulos, An Zhang, Valerie Tsang, Thomas Ryll
  • Patent number: 9096879
    Abstract: The present invention relates to methods of reducing substitution of amino acids during the production of polypeptides of interest in mammalian cells. By varying the concentration of amino acids in the culture medium, heterogeneity of the polypeptide's amino acid sequence is decreased, leading to higher yields of functional protein.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: August 4, 2015
    Assignee: BIOGEN MA INC.
    Inventors: Anurag Khetan, Yao-ming Huang, Jana Dolnikova, Nels Pederson, Helena Yusuf-Makagiansar, Paul Chen, Thomas Ryll
  • Publication number: 20140060316
    Abstract: The present invention relates to a vibration energy harvest device. In the present invention, the vibration energy harvest device is provided for being used to recycle the mechanical energy and thermal energy generated during the vibration, and effectively to improve the power generation efficiency with newly added hydraulic motor and electricity generating unit. Wherein by using an ameliorating valve module and removing the damping hole in the prior art, no matter the damping oil flows from inner cylinder module through hydraulic motor to outer cylinder module or the contrary direction, the flowing damping oil could avoid the hydraulic motor from reciprocating to improve the power generation efficiency.
    Type: Application
    Filed: August 13, 2013
    Publication date: March 6, 2014
    Inventors: Chuen-An Chen, Che-Pin Chen, Yao-Ming Huang, Chieh Tung, Ming-Hua Shih, Te-Ming Yeh
  • Patent number: 8531259
    Abstract: A proportional electromagnet includes a cylindrical shell, first and second covers connected to two ends of the shell by riveting, a metal core inserted through an axial defined in the second cover and formed with a first section located in the shell and a second section located outside the shell, a coil unit provided between the shell and the metal core, a supporting element provided on the first section of the metal core, a bushing provided on the second section of the metal core, a copper ring provided on the first section of the metal core to improve magnetic thrust of the proportional electromagnet, a stop provided on the first section of the metal core, and a magnetic shield provided between the first section of the metal core and the coil unit to direct magnetic flux toward the supporting element and the metal core to stably drive the metal core.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: September 10, 2013
    Assignee: Chung-Shan Institute of Science and Technology, Armaments, Bureau, Ministry of National Defense
    Inventors: Chuen-An Chen, Chieh Tung, Che-Pin Chen, Min-Fang Lo, Yao-Ming Huang
  • Publication number: 20130096283
    Abstract: The present invention relates to methods of reducing substitution of amino acids during the production of polypeptides of interest in mammalian cells. By varying the concentration of amino acids in the culture medium, heterogeneity of the polypeptide's amino acid sequence is decreased, leading to higher yields of functional protein.
    Type: Application
    Filed: November 24, 2009
    Publication date: April 18, 2013
    Applicant: Biogen Idec MA inc.
    Inventors: Anurag Khetan, Yao-ming Huang, Jana Dolnikova, Nels Pederson, Helena Yusuf-Makagiansar, Paul Chen, Thomas Ryll
  • Publication number: 20120313739
    Abstract: A proportional electromagnet includes a cylindrical shell, first and second covers connected to two ends of the shell by riveting, a metal core inserted through an axial defined in the second cover and formed with a first section located in the shell and a second section located outside the shell, a coil unit provided between the shell and the metal core, a supporting element provided on the first section of the metal core, a bushing provided on the second section of the metal core, a copper ring provided on the first section of the metal core to improve magnetic thrust of the proportional electromagnet, a stop provided on the first section of the metal core, and a magnetic shield provided between the first section of the metal core and the coil unit to direct magnetic flux toward the supporting element and the metal core to stably drive the metal core.
    Type: Application
    Filed: December 9, 2011
    Publication date: December 13, 2012
    Applicant: Chung-Shan Institute of Science and Technology, Armaments, Bureau, Ministry of National Defense
    Inventors: Chuen-An Chen, Chieh Tung, Che-Pin Chen, Min-Fang Lo, Yao-Ming Huang