Patents by Inventor Yao-Sheng Tung

Yao-Sheng Tung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEMS AND METHODS FOR OPENING OF A TISSUE BARRIER IN PRIMATES
    Publication number: 20220193457
    Abstract: Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions.
    Type: Application
    Filed: March 9, 2022
    Publication date: June 23, 2022
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Elisa E. Konofagou, Fabrice Marquet, Yao-Sheng Tung
  • Systems and methods for opening of a tissue barrier in primates
    Patent number: 11273329
    Abstract: Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: March 15, 2022
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Elisa E. Konofagou, Fabrice Marquet, Yao-Sheng Tung
  • SYSTEMS AND METHODS FOR OPENING OF A TISSUE BARRIER IN PRIMATES
    Publication number: 20200086146
    Abstract: Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions.
    Type: Application
    Filed: September 18, 2019
    Publication date: March 19, 2020
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Elisa E. Konofagou, Fabrice Marquet, Yao-Sheng Tung
  • Systems and methods for opening of a tissue barrier in primates
    Patent number: 10441820
    Abstract: Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: October 15, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Elisa E. Konofagou, Fabrice Marquet, Yao-Sheng Tung
  • SYSTEMS AND METHODS FOR REAL-TIME, TRANSCRANIAL MONITORING OF BLOOD-BRAIN BARRIER OPENING
    Publication number: 20190192112
    Abstract: Systems and techniques for real-time, transcranial monitoring of safe blood-brain barrier opening include determining an approach angle for targeted blood-brain barrier opening proximate a predetermined region in a brain of a patient, and positioning an ultrasound transducer to generate a focused ultrasound signal at the determined approach angle to the predetermined region in the brain.
    Type: Application
    Filed: July 23, 2018
    Publication date: June 27, 2019
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Elisa E. Konofagou, Tobias Teichert, Vincent P. Ferrera, Fabrice Marquet, Yao-Sheng Tung, Shih-Ying Wu
  • SYSTEMS AND METHODS FOR OPENING OF A TISSUE BARRIER IN PRIMATES
    Publication number: 20140114216
    Abstract: Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions.
    Type: Application
    Filed: November 26, 2013
    Publication date: April 24, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Elisa E. KONOFAGOU, Fabrice Marquet, Yao-Sheng Tung