Abstract: The present disclosure relates to an improved immune cell expressing an antigen-specific receptor such as a CAR or TCR, in which SUV39H1 is inactivated, optionally combined with disruption of the TRAC locus and/or deletion of one or more ITAMs. The disclosure also provides compositions comprising such cells, methods of producing such cells, and uses of such cells in adoptive cell therapy, e.g. in cancer or inflammatory diseases.

Abstract: A method, system and apparatus are disclosed. In at least one embodiment, a serving node is configured to communicate with a target node and a wireless device. The serving node is configured to cause transmission of wireless device data to the target node for storage in a buffer of the target node. The serving node is configured to cause, after transmission of the data, handover of the wireless device to the target node.

Abstract: Described herein are antibodies, immunogenic fragments and compositions thereof targeting the killer-cell immunoglobulin-like receptor protein KIR3DL3, as well as methods of using the same for the treatment of human diseases including cancer. In certain embodiments, the disclosure relates to an antibody or an immunogenic fragment thereof that specifically binds to KIR3DL3 protein, wherein the antibody or the immunogenic fragment thereof specifically binds to a KIR3DL3 epitope comprising the whole extracellular domain or a portion thereof.

Abstract: The invention provides a heat-release retardative cold conduction device with multi-cavity and multi-phase change and a method of calculating the transfer heat thereof. The device comprises an inner cavity, a heat-release retardative cavity, and a phase-change cold storage cavity. The inner cavity is a hollow sealing structure with an unobstructed central core and two closed ends, and a refrigerant is placed in the cavity; the heat-release retardative cavity is encased on a bottom region outside of the inner cavity, and a phase-change heat storage material is placed in the heat-release retardative cavity; the phase-change cold storage cavity is encased on the outside of the inner cavity and is located in a region above the heat-release retardative cavity, wherein the phase-change cold storage cavity does not completely encase a top region outside of the inner cavity, and a phase-change cold storage material is placed in the phase-change cold storage cavity.

Abstract: A method, system and apparatus for recognizing continuous driving style are provided, which involve the intelligent vehicles field. The method comprises: collecting multi-dimensional driving data from a plurality of drivers in daily driving scenarios, segmenting the driving data to obtain a plurality of driving segments, calculating statistical features of each driving segment to determine high-dimensional continuous driving statistical features, reducing dimensionality of the driving statistical features to generate common factors for each driving segment, representing each driving segment with a driving word based on the common factors, representing all the driving segments of a target driver as a driving word sequence, constructing a hierarchical latent model of driving behavior, and inputting the driving word sequence into the hierarchical latent model of driving behavior to determine the continuous driving style of the target driver.

Abstract: A laser hair removal handle has: a water supply block, a hollow metal structural member, and a fast axis collimating lens. A laser is mounted at a transverse edge of the L-shaped water supply block, and the hollow metal structural member is mounted at a vertical edge of the L-shaped water supply block, so that diffuse reflection light formed after a laser irradiates the skin enters a cavity of the hollow metal structural member. Since the hollow metal structural member is made of a metal material, the energy of the diffuse reflection light is effectively absorbed, and the effect of the diffuse reflection light on the emitted laser is reduced. The laser emitted by the laser is collimated by using the fast axis collimating lens. Compared with an optical waveguide in the prior art, energy loss is lowered.

Abstract: The present invention provides a method of calculating the dosage of phase change coarse aggregate, which comprises the steps of setting a regulatory temperature difference of a thermoregulating cement-stabilized layer, the regulatory temperature difference being the difference between the peak temperature of the thermoregulating cement-stabilized layer and the peak temperature of a conventional cement-stabilized layer, wherein the thermoregulating cement-stabilized layer is mixed with a phase change coarse aggregate, while the conventional cement-stabilized layer is not mixed with a phase change coarse aggregate; calculating a regulatory heat based on the regulatory temperature difference, wherein when a temperature change of the conventional cement-stabilized layer is the regulatory temperature difference, a heat change of the conventional cement-stabilized layer is the regulatory heat; and calculating a volume occupied by the phase change coarse aggregate in the thermoregulating cement-stabilized layer bas

Abstract: A method, system and apparatus for recognizing continuous driving style are provided, which involve the intelligent vehicles field. The method comprises: collecting multi-dimensional driving data from a plurality of drivers in daily driving scenarios, segmenting the driving data to obtain a plurality of driving segments, calculating statistical features of each driving segment to determine high-dimensional continuous driving statistical features, reducing dimensionality of the driving statistical features to generate common factors for each driving segment, representing each driving segment with a driving word based on the common factors, representing all the driving segments of a target driver as a driving word sequence, constructing a hierarchical latent model of driving behavior, and inputting the driving word sequence into the hierarchical latent model of driving behavior to determine the continuous driving style of the target driver.

Abstract: The present invention discloses a method for designing an interference noise of speech based on the human speech structure, including the following steps: (1): obtaining a large amount of speech data containing different speakers and different speech contents, extracting voiceprint information, and then building an initial speech data set; (2): for each user, obtaining a small amount of speech data of the user, extracting voiceprint information, and then matching the most similar speech data in the initial speech data set; (3): performing data augmentation on the matched speech data; (4): segmenting the augmented speech data with a phoneme segmentation algorithm to form a vowel data set and a consonant data set; (5): constructing three noise sequences based on the vowel data set and the consonant data set, and performing superimposition to obtain an interference noise; and (6): continuously generating and playing randomly generated interference noise, and continuously injecting the interference noise into rec

Abstract: The present application discloses an optical system, a camera module, and a terminal device. The optical system includes a first lens, a second lens, a third lens, a fourth lens, a fifth lens, and a sixth lens. The first lens has negative refractive power, the second lens has negative refractive power, the third lens has positive refractive power, the fourth lens has refractive power, the fifth lens has refractive power, and the sixth lens has refractive power. The optical system satisfies the following relational expression: 1.2<IMGH/EPD<1.4. Wherein, IMGH is half of an image height corresponding to a maximum field of view of the optical system, and EPD is an entrance pupil diameter of the optical system. The optical system of the present application may have large aperture and high imaging quality while maintaining a lightweight and compact design.

Abstract: Provided herein are methods of modifying immune cell activity by altering KJR2DL5 expression and/or activity. The methods, which include administering to a subject one or more agents that decrease KJR2DL5 expression and/or activity, increase immune cell function, and treat diseases such as cancer and infectious diseases.

Abstract: Described herein are antibodies, immunogenic fragments and compositions thereof targeting the killer-cell immunoglobulin-like receptor protein KIR3DL3, as well as methods of using the same for the treatment of human diseases including cancer. In certain embodiments, the disclosure relates to an antibody or an immunogenic fragment thereof that specifically binds to KIR3DL3 protein, wherein the antibody or the immunogenic fragment thereof specifically binds to a KIR3DL3 epitope comprising the whole extracellular domain or a portion thereof.

Abstract: Provided are a main control system and a device for a nuclear magnetic resonance logging while drilling tool, the system includes: a digital signal processor, an auxiliary measurement module, a pulse signal generation module and a memory disposed in a downhole drilling tool; wherein the digital signal processor is communicatively connected to an upper computer arranged on the ground, the auxiliary measurement module and the pulse signal generation module respectively; the memory is communicatively connected to the pulse signal generation module. The main control system and a device for a nuclear magnetic resonance logging while drilling tool achieve the effect of improving the accuracy of the logging data.

Abstract: Disclosed belongs to the technical field of oil and gas field development engineering, and particularly relates to a super heavy oil development method for strengthening an SAGD steam chamber to break through a low physical property reservoir. The super heavy oil development method for strengthening the SAGD steam chamber to break through the low physical property reservoir includes the following steps: (1) selection of a developed oil reservoir; (2) well distribution; (3) steam chamber forming; (4) steam chamber expansion; (5) steam chamber strengthening. The method may enhance the ability of the steam chamber to break through the low physical property reservoir, enlarge the development height of the steam chamber, and further improve the SAGD development effect of super heavy oil.

Abstract: Disclosed belongs to the technical field of oil and gas field development engineering, and particularly relates to a super heavy oil development method for strengthening an SAGD steam chamber to break through a low physical property reservoir. The super heavy oil development method for strengthening the SAGD steam chamber to break through the low physical property reservoir includes the following steps: (1) selection of a developed oil reservoir; (2) well distribution; (3) steam chamber forming; (4) steam chamber expansion; (5) steam chamber strengthening. The method may enhance the ability of the steam chamber to break through the low physical property reservoir, enlarge the development height of the steam chamber, and further improve the SAGD development effect of super heavy oil.

Abstract: Provided is an array antenna driving method and device for a three-dimensional scanning nuclear magnetic resonance imager, wherein each antenna to be operated is driven to transmit a nuclear magnetic pulse signal by receiving a control command sent by a control system; parsing the control command to generate a pulse transmission timing signal and an antenna switching control signal; processing an externally inputted high voltage signal according to the pulse transmission timing signal to output high voltage radio frequency pulses of a plurality of channels; and selecting a high voltage radio frequency pulse of at least one channel and the antenna to be operated in the nuclear magnetic resonance pulse array antenna according to the antenna switching control signal, and superposing the selected high voltage radio frequency pulse. The device of the present invention can improve multi-layer slice information detection of signals in circumferentially different azimuth zones.

Abstract: The present disclosure provides a light transmission processing system and method for a solar chip module. The light transmission processing system includes: an ink printing unit configured to print a preset pattern on an upper surface of the chip module with a UV ink so that a hollowed out region is formed on an area of the upper surface of the chip module not covered by the pattern, the chip module including a transparent substrate and a chip layer superposed on an upper surface of the transparent substrate; a curing unit configured to cure the UV ink printed on the chip module with UV light to form a UV ink protective film; and a layer removing unit configured to remove a portion of the chip layer corresponding to the hollowed out region to expose a portion of the transparent substrate corresponding to the hollowed out region.

Abstract: The disclosure provides a main control system and a device for a nuclear magnetic resonance logging while drilling tool, the system comprises: a digital signal processor, an auxiliary measurement module, a pulse signal generation module and a memory disposed in a downhole drilling tool; wherein the digital signal processor is communicatively connected to an upper computer arranged on the ground, the auxiliary measurement module and the pulse signal generation module respectively; the memory is communicatively connected to the pulse signal generation module. The main control system and a device for a nuclear magnetic resonance logging while drilling tool achieve the effect of improving the accuracy of the logging data.

Abstract: Provided is an array antenna driving method and device for a three-dimensional scanning nuclear magnetic resonance imager, wherein each antenna to be operated is driven to transmit a nuclear magnetic pulse signal by receiving a control command sent by a control system; parsing the control command to generate a pulse transmission timing signal and an antenna switching control signal; processing an externally inputted high voltage signal according to the pulse transmission timing signal to output high voltage radio frequency pulses of a plurality of channels; and selecting a high voltage radio frequency pulse of at least one channel and the antenna to be operated in the nuclear magnetic resonance pulse array antenna according to the antenna switching control signal, and superposing the selected high voltage radio frequency pulse. The device of the present invention can improve multi-layer slice information detection of signals in circumferentially different azimuth zones.

Abstract: Provided is a method for PCI classified self-configuration, including: according to the characteristic of PCI code, dividing all PCIs into ?L large groups in accordance with a step length ?L, and then dividing resources of each of the large groups into ?S small groups in accordance with a step length ?S, generating a PCI resource list, and identifying each PCI by three sections of address codes representing a large group number, a small group number and an intra-group number of the PCI, respectively; mapping the PCI resources one by one to new base stations in accordance with a classification that each new station and heterogeneous nodes covered thereby correspond to a small group of PCI resources; allocating a first PCI in each small group of PCI resources to a new base station, and randomly allocating the remaining PCIs in the small group of PCI resources to the covered heterogeneous nodes.