Abstract: The present invention provides novel compounds having the general formula: (I) wherein R1 to R6, X, Y, and Z are as described herein, or a pharmaceutically acceptable salt thereof, compositions including the compounds and methods of using the compounds.

Abstract: An electrochemical aptamer-based (E-AB) sensor is disclosed. The sensor is a closed bipolar electrode having a first end and a second end. The first end comprises an electrochromic material. The second end comprises an electrocatalyst and an oligonucleotide aptamer tethered to the second end. Further, the oligonucleotide aptamer is labelled with a redox indicator.

Abstract: An aging reprogramming composition, a use method therefor, a kit containing the composition, and the use of the composition in tissue repair, tissue regeneration, organ regeneration, aging reversion, or any combination thereof. The present invention relates to SOX1, SOX2, SOX3, RCOR2, GMNN, GATA1, GATA2, GATA3, GATA4, GATA6, FOXA2, SOX7, SOX17, NKX3.1, NR5A2, C/EBP?, OCT4, PAX1, Klf4, Klf2, GLIS1 and c-MYC, which are used as inducing factors to reprogram cells, tissues or organs to restore a youthful state. Provided is a composition of an activation inducing factor in the form of an engineered nucleic acid, an engineered cell, an engineered protein, a chemical agent, or any combination thereof, wherein the composition is used for treating diseases, preventing diseases, modulating tissue repair, modulating tissue regeneration, or any combination thereof.

Abstract: A robot includes a torso structure, a head structure, robotic arms, gripper structures, and a chassis driving structure. The torso structure includes a lower leg assembly, a thigh assembly, and a thoracic cavity assembly. A first torso motor, a second torso motor, and a third torso motor enable a multi-joint rotation within a plane formed by a first direction and a second direction. A fourth torso motor drives the thoracic cavity assembly to rotate relative to the thigh assembly around an output shaft of the fourth torso motor within a plane formed by the second direction and a third direction. Two opposite sides of the end of the thoracic cavity assembly facing away from the thigh assembly are provided with the robotic arms respectively, and the gripper structures are securely mounted at tail ends of the robotic arms respectively.

Abstract: A robotic arm for the robot includes a robotic arm base, a robotic arm control board, a first joint mechanism, a second joint mechanism, a robotic upper arm structure, a third joint mechanism, a fourth joint mechanism, a robotic forearm structure, a fifth joint mechanism, and a sixth joint mechanism. The robotic arm control board is disposed within the robotic arm base, the robotic upper arm structure is connected to the robotic arm base through the second joint mechanism and the first joint mechanism, the robotic forearm structure is connected to the robotic upper arm structure through the fourth joint mechanism and the third joint mechanism, the fifth joint mechanism and the sixth joint mechanism are disposed at a tail end of the robotic forearm structure, and the robotic forearm structure is connected to a gripper structure of the robot through the fifth joint mechanism and the sixth joint mechanism.

Abstract: The present invention relates to compounds of formula (Ia), (Ia), wherein R1 to R3, Q1, Q2, A1 to A6 are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

Abstract: The present invention provides a composition based on three factors and used for restoring viability of cells, tissue, or organs of a subject, and a method for using the composition to restore viability of the cells, tissue, or organs of the subject. By means of the composition and the method, the viability or functions of the cells, tissue, or organs of the subject can be restored. The composition and the method can be used for any disease or damage that requires repairing or replacement of malfunctional tissue.

Abstract: The present disclosure provides a juvenile fish limb identification method based on a multi-scale cascaded perceptual convolutional neural network. The method includes the following steps: acquiring a video sequence of a juvenile fish, dividing a fish body into five non-overlapping parts, performing semantic annotation on the five non-overlapping parts, and taking the five non-overlapping parts as an input of the multi-scale cascaded perceptual convolutional neural network; and using a convolutional layer as a feature extractor, performing feature extraction on an input image containing the annotation of each limb, inputting extracted features into an Attention-region proposal network (RPN) structure, determining a category of each pixel, and generating a limb mask of each limb category using a multi-scale cascade method. According to the method, the limbs of the juvenile fish can be efficiently and accurately identified, and technical support is provided for posture quantification of the juvenile fish.

Abstract: A herbicidal composition includes glyphosate or a derivative thereof, a phosphate ester, and a surfactant component. The phosphate ester is present in an amount of from about 1 to about 15 weight percent actives based on a total weight of the composition. The surfactant component includes at least one of a first surfactant, a second surfactant, and a third surfactant. Each of the first, second, and third surfactants, if utilized, is independently present in an amount of from about 1 to about 15 weight percent actives based on a total weight of the composition.

Abstract: A herbicidal composition includes glyphosate and first and second surfactants. The first surfactant has the structure: wherein R1 is a linear or branched, saturated or unsaturated alkyl group having from 5 to 22 carbon atoms, each of R2, R3 and R4 is independently an alkylene oxide group, a is from 0 to 10, each of b and c is independently from about 1 to about 10; and n is 0 to about 3. The second surfactant has the structure: wherein R5 is a linear or branched, saturated or unsaturated alkyl group having from 8 to 18 carbon atoms, each of R6 and R7 is independently an alkylene oxide group, and each of d and e is independently from about 1 to about 5.

Abstract: The present disclosure provides an adjoint automatic monitoring device and method for a deposition rate of salt mist. The adjoint automatic monitoring device includes: a wet candle method-based salt mist deposition rate acquisition unit, a single chip, a digital-to-analog (D/A) conversion circuit, and a data acquisition module. According to the present disclosure, a current value and a height variation of a solution in a trapping pool of the wet candle method-based salt mist deposition rate acquisition unit are acquired by the data acquisition module, and then the deposition rate of salt mist is calculated by the single chip. Real-time online monitoring of the deposition rate of salt mist is realized.

Abstract: Provided are a method and an apparatus for determining an energy calibration of a radiation detector, a device, and a medium.

Abstract: Described herein are pyrido-pyrimidinone and pteridinone compounds or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods treating cancer, alone and in combination with other therapeutic agents.

Abstract: The present invention provides novel compounds having the general formula: wherein ring A, ring B, ring C, bond a, and R1 to R7 are as described herein, or a pharmaceutically acceptable salt thereof, compositions including the compounds and methods of using the compounds.

Abstract: The present invention relates to compounds of formula (I), wherein R1-R5 and L are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

Abstract: A calibration and verification system for a directional sensor, including an industrial control computer and a directional sensor, wherein the industrial control computer is connected to a sensor signal acquisition system, a first triaxial Helmholtz coil and a second triaxial Helmholtz coil, respectively, wherein a heating calibration turntable is disposed in the first triaxial Helmholtz coil and configured to heat and calibrate the directional sensor, and wherein a high-precision inclination and azimuth test turntable is disposed in the second triaxial Helmholtz coil and configured to verify the directional sensor.

Abstract: The present invention discloses a method and system for evaluating road safety based on multi-dimensional influencing factors, and relates to the field of road safety technologies. Based on historical traffic data and corresponding safety influencing factors, safety evaluation models in different dimensions are respectively constructed, and road safety risk exposure is classified flexibly. The safety evaluation models in macro and micro dimensions are linked by using a constraint function, and influence mechanisms of the safety influencing factors are determined respectively. Specifically, a safety evaluation model is constructed and obtained for each sub-region in a limited region range. The safety evaluation model is applied to obtain influencing factors of safety of each traffic road in the sub-region, and safety evaluation is performed on the sub-region.

Abstract: The present disclosure provides a juvenile fish limb identification method based on a multi-scale cascaded perceptual convolutional neural network. The method includes the following steps: acquiring a video sequence of a juvenile fish, dividing a fish body into five non-overlapping parts, performing semantic annotation on the five non-overlapping parts, and taking the five non-overlapping parts as an input of the multi-scale cascaded perceptual convolutional neural network; and using a convolutional layer as a feature extractor, performing feature extraction on an input image containing the annotation of each limb, inputting extracted features into an Attention-region proposal network (RPN) structure, determining a category of each pixel, and generating a limb mask of each limb category using a multi-scale cascade method. According to the method, the limbs of the juvenile fish can be efficiently and accurately identified, and technical support is provided for posture quantification of the juvenile fish.