Patents by Inventor Yao Xiong

Yao Xiong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210371526
    Abstract: Provided is a tetravalent homodimeric bispecific antibody molecule simultaneously targeting an immune effector cell antigen CD3 and a tumor-associated antigen, wherein the bispecific antibody molecule contains, in order from N-terminus to C-terminus, a first single chain Fv, a second single chain Fv and a Fc fragment; wherein the first single chain Fv can specifically bind to the tumor-associated antigen, the second single chain Fv can specifically bind to CD3, and the first and the second single chain Fvs are connected by a linker peptide, while the second single chain Fv and the Fc fragment are directly connected or connected by a linker peptide; and the Fc fragment does not have effector functions such as CDC, ADCC and ADCP.
    Type: Application
    Filed: October 31, 2019
    Publication date: December 2, 2021
    Inventors: Qiang Li, Xinlu Ma, Shixiang Jia, Yuan Yan, Yuhua Zhang, Li Zhou, Rilong Sun, Xueyuan Cui, Lingju Yu, Yujie Yan, Yingying Jin, Yao Xiong, Yuanli Li, Si Chen, Xuemei Liu, Jiasheng Diao
  • Publication number: 20210230478
    Abstract: Particulate compositions including a plurality of particles containing oil field chemicals encapsulated in a water soluble, water swellable, or water degradable matrix material are disclosed. The oil field chemicals may be corrosion inhibitors and the particulate composition may be prepared by spray drying mixtures of matrix material and oil field chemicals. The particulate compositions are designed to efficiently deliver the chemicals to the water phase of a multiphase environment, such as an oil/water environment.
    Type: Application
    Filed: January 13, 2021
    Publication date: July 29, 2021
    Inventors: Fang Cao, Yao Xiong, James D. Oxley, Wei Li, Satish Bodige, Abhimanyu O. Patil, Harry W. Deckman
  • Publication number: 20200309709
    Abstract: A rotating seal-type liquid testing apparatus includes a lower cup component, an upper cup body, a top cover and a testing element. The lower cup component includes a lower cup body, a high liquid baffle, a low liquid baffle and a water-absorbing sealing plug. The low liquid baffle and the high liquid baffle divide a bottom of an inner cavity of the lower cup body into a reaction region and a cut-off region. An edge of a bottom surface of the inner cavity of the lower cup body is provided with a vent hole, and the vent hole is positioned in the cut-off region. The upper cup body is disposed in the lower cup body, a bottom surface of an inner cavity of the upper cup body is provided with a liquid outlet, and the liquid outlet is connected to the reaction region in the lower cup body.
    Type: Application
    Filed: June 12, 2020
    Publication date: October 1, 2020
    Applicant: HANGZHOU ALLTEST BIOTECH CO., LTD
    Inventors: Haijian WANG, Weike LU, Fei GAO, Yao XIONG
  • Patent number: 10738605
    Abstract: A method for testing properties of a pressurized multiphase fluid sample containing at least hydrocarbons and water. The pressurized multiphase fluid sample is placed into a first pressurized chamber of a testing device. The water is separated from the hydrocarbons. At least part of the separated water is flowed through a first outlet in the first pressurized chamber and into a second pressurized chamber. The second pressurized chamber is optionally isolated from the first pressurized chamber. A pH level of the separated water is tested in the second pressurized chamber. Microbial activity and growth is tested for in the pressurized multiphase fluid in the first pressurized chamber. A pressure of the pressurized multiphase fluid is substantially maintained throughout the placing, separating, flowing, isolating, and testing steps.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: August 11, 2020
    Assignee: ExxonMobil Upstream Research Company
    Inventors: Joseph W. Stolle, Yao Xiong, Dennis R. Enning, David S. Fischer, Manuel A. Castelan
  • Publication number: 20200150025
    Abstract: Carbon steels are desirable for many applications due to their hardness and low cost. Susceptibility toward corrosion can complicate the use of carbon steels, and there is presently no ready way to predict susceptibility toward corrosion for a given carbon steel under a particular set of corrosive conditions. Methods for predicting susceptibility toward corrosion and determining the suitability of a carbon steel may comprise: obtaining a group of carbon steel samples, each carbon steel sample having an unknown rate of corrosion and a microstructure; measuring a quantity of carbides within the microstructure of each carbon steel sample having an unknown rate of corrosion; and determining a relative order of susceptibility toward corrosion within the group of carbon steel samples based upon the quantity of carbides within the microstructure of each carbon steel sample.
    Type: Application
    Filed: October 23, 2019
    Publication date: May 14, 2020
    Inventors: Fang Cao, Yao Xiong, David S. Fischer, Jorge L. Pacheco
  • Publication number: 20200063028
    Abstract: Capsules, systems and methods for delivering chemical components to multiphase environments are disclosed. The systems and methods utilize delivery capsules within which the chemical components are encapsulated. The chemical components may be corrosion inhibitors or biocides and the multiphase environment an oil/water environment, for example, within an oil transport pipeline. The systems and methods allow delivery of the capsules to targeted areas of the multiphase environment, for example, to a water phase or a water/metal interface.
    Type: Application
    Filed: August 16, 2019
    Publication date: February 27, 2020
    Inventors: Fang Cao, Mohsen S. Yeganeh, Yao Xiong, David S. Fischer, Aruna Mohan, Wei Li
  • Publication number: 20180275111
    Abstract: A method for testing properties of a pressurized multiphase fluid sample containing at least hydrocarbons and water. The pressurized multiphase fluid sample is placed into a first pressurized chamber of a testing device. The water is separated from the hydrocarbons. At least part of the separated water is flowed through a first outlet in the first pressurized chamber and into a second pressurized chamber. The second pressurized chamber is optionally isolated from the first pressurized chamber. A pH level of the separated water is tested in the second pressurized chamber. Microbial activity and growth is tested for in the pressurized multiphase fluid in the first pressurized chamber. A pressure of the pressurized multiphase fluid is substantially maintained throughout the placing, separating, flowing, isolating, and testing steps.
    Type: Application
    Filed: March 8, 2018
    Publication date: September 27, 2018
    Inventors: Joseph W. Stolle, Yao Xiong, Dennis R. Enning, David S. Fischer, Manuel A. Castelan
  • Publication number: 20150218587
    Abstract: The presently claimed invention applies to a genetic material processing, manipulation and transfection method and related product. The claimed invention relates to a method for changing the inherited characteristics of a cell through micro-beam chromosome modification. In one preferred embodiment, improvements to ‘genomic surgery’ are applied to modify source cell genetic material (101). Upon micro-beam welding of combined genetic material (301), transfection takes place either by using a laser beam with a wavelength of 337 nm to perforate a hole (303) on receptor cell (305) or micro-tube control technology is then applied to carry combined genetic material (301) through the micro-pore (303) into the receptor cell (305), inserting the welded chromosome segment (301) by injection. Combined genetic material may be placed anywhere within receptor cell (305), including transfection through nuclear hole (307) into the cell nucleus (311).
    Type: Application
    Filed: November 10, 2014
    Publication date: August 6, 2015
    Applicant: GENEFORGE LIMITED
    Inventor: Yao-Xiong HUANG
  • Patent number: 8883505
    Abstract: The presently claimed invention applies to a genetic material processing and manipulation method and related product. The claimed invention relates to a method for changing the inherited characteristics of a cell through micro-beam chromosome modification. In one preferred embodiment, improvements to ‘genomic surgery’ are applied to modify source cell genetic material (101). Source cell (106) is stabilized through micro-pipette (102) applied negative pressure. Excised genetic material (101) undergoes a pre-cutting manipulation step (205) to enhance subsequent genetic manipulation. In an additional embodiment genetic material manipulation is aided by a spindle cutting step (303). The presently claimed invention provides a high quality alternate approach to directed genetic recombination without requiring the use of restriction enzymes and is used for chromosomal repair, removal of defects and new organism creation.
    Type: Grant
    Filed: November 23, 2012
    Date of Patent: November 11, 2014
    Assignee: Geneforge Limited
    Inventor: Yao-Xiong Huang
  • Publication number: 20130078723
    Abstract: The presently claimed invention applies to a genetic material processing and manipulation method and related product. The claimed invention relates to a method for changing the inherited characteristics of a cell through micro-beam chromosome modification. In one preferred embodiment, improvements to ‘genomic surgery’ are applied to modify source cell genetic material (101). Source cell (106) is stabilized through micro-pipette (102) applied negative pressure. Excised genetic material (101) undergoes a pre-cutting manipulation step (205) to enhance subsequent genetic manipulation. In an additional embodiment genetic material manipulation is aided by a spindle cutting step (303). The presently claimed invention provides a high quality alternate approach to directed genetic recombination without requiring the use of restriction enzymes and is used for chromosomal repair, removal of defects and new organism creation.
    Type: Application
    Filed: November 23, 2012
    Publication date: March 28, 2013
    Inventor: Yao-Xiong Huang
  • Patent number: 7316908
    Abstract: An isolated protein sequence or peptide from the E2, E6 or E7 early coding region of human papillomavirus (HPV) that is soluble in an aqueous medium, and characterized by a relative paucity of tryptophan, methionine and cysteine residues, and a relative abundance of glycine and asparagine residues. Also disclosed are isolated protein sequences or peptides from the E2, E6 or E7 early coding regions of HPV 16 and 18 and methodologies for detecting or diagnosing cancer or cellular abnormalities. Detection or diagnosis of Cancer or cellular abnormalities may include detecting or diagnosing pre-cancerous or pre-malignant conditions, cervical dysplasia, cervical carcinoma, koilocytosis, hyperkeratosis, intraepithelial lesions, and other cancers.
    Type: Grant
    Filed: August 22, 2005
    Date of Patent: January 8, 2008
    Inventors: Yao Xiong Hu, Mark J. Rosenfeld
  • Patent number: 7314630
    Abstract: An isolated sequence or peptide isolated from an E2, E4, E6, E7 early or late coding region of human papillomavirus (HPV) that is soluble in aqueous medium, and characterized by a linkage to another protein sequence or peptide isolated from the E2, E4, E6, E7 early or late coding region of HPV by a spacer sequence, wherein the isolated protein sequence or peptide consists of more than 50% hydrophilic amino acids, and is recognized by a specific antibody of HPV. Also disclosed are isolated protein sequences or peptides from Harvey Ras (H-Ras), Kirsten Ras (K-Ras), and phosphatase and tensin homologue (PTEN) tumor suppressor proteins and Chlamydia trachomatis heat shock protein 60 (CHSP60 groEL1) and methods for detecting or diagnosing cancer or cellular abnormalities.
    Type: Grant
    Filed: January 7, 2005
    Date of Patent: January 1, 2008
    Inventor: Yao-Xiong Hu
  • Patent number: 7267961
    Abstract: An isolated protein sequence or peptide from the E2, E6 or E7 early coding region of human papillomavirus (HPV) that is soluble in an aqueous medium, and characterized by a relative paucity of tryptophan, methionine and cysteine residues, and a relative abundance of glycine and asparagine residues. Also disclosed are isolated protein sequences or peptides from the E2, E6 or E7 early coding regions of HPV 16 and 18 and methodologies for detecting or diagnosing cancer or cellular abnormalities. Detection or diagnosis of Cancer or cellular abnormalities may include detecting or diagnosing pre-cancerous or pre-malignant conditions, cervical dysplasia, cervical carcinoma, koilocytosis, hyperkeratosis, intraepithelial lesions, and other cancers.
    Type: Grant
    Filed: November 23, 2004
    Date of Patent: September 11, 2007
    Inventors: Yao Xiong Hu, Mark J. Rosenfeld
  • Publication number: 20060154238
    Abstract: An isolated sequence or peptide isolated from an E2, E4, E6, E7 early or late coding region of human papillomavirus (HPV) that is soluble in aqueous medium, and characterized by a linkage to another protein sequence or peptide isolated from the E2, E4, E6, E7 early or late coding region of HPV by a spacer sequence, wherein the isolated protein sequence or peptide consists of more than 50% hydrophilic amino acids, and is recognized by a specific antibody of HPV. Also disclosed are isolated protein sequences or peptides from Harvey Ras (H-Ras), Kirsten Ras (K-Ras), and phosphatase and tensin homologue (PTEN) tumor suppressor proteins and Chlamydia trachomatis heat shock protein 60 (CHSP60 groEL1) and methods for detecting or diagnosing cancer or cellular abnormalities.
    Type: Application
    Filed: January 7, 2005
    Publication date: July 13, 2006
    Inventor: Yao-Xiong Hu
  • Patent number: 6933123
    Abstract: An isolated protein sequence or peptide from the E2, E6 or E7 early coding region of human papillomavirus (HPV) that is soluble in an aqueous medium, and characterized by a relative paucity of tryptophan, methionine and cysteine residues, and a relative abundance of glycine and asparagine residues. Also disclosed are isolated protein sequences or peptides from the E2, E6 or E7 early coding regions of HPV 16 and 18 and methodologies for detecting or diagnosing cancer or cellular abnormalities. Detection or diagnosis of Cancer or cellular abnormalities may include detecting or diagnosing pre-cancerous or pre-malignant conditions, cervical dysplasia, cervical carcinoma, koilocytosis, hyperkeratosis, intraepithelial lesions, and other cancers.
    Type: Grant
    Filed: July 1, 2003
    Date of Patent: August 23, 2005
    Inventors: Yao Xiong Hu, Mark J. Rosenfeld
  • Publication number: 20040110925
    Abstract: An isolated protein sequence or peptide from the E2, E6 or E7 early coding region of human papillomavirus (HPV) that is soluble in an aqueous medium, and characterized by a relative paucity of tryptophan, methionine and cysteine residues, and a relative abundance of glycine and asparagine residues. Also disclosed are isolated protein sequences or peptides from the E2, E6 or E7 early coding regions of HPV 16 and 18 and methodologies for detecting or diagnosing cancer or cellular abnormalities. Detection or diagnosis of Cancer or cellular abnormalities may include detecting or diagnosing pre-cancerous or pre-malignant conditions, cervical dysplasia, cervical carcinoma, koilocytosis, hyperkeratosis, intraepithelial lesions, and other cancers.
    Type: Application
    Filed: July 1, 2003
    Publication date: June 10, 2004
    Inventors: Yao Xiong Hu, Mark Jay Rosenfeld
  • Patent number: 6743593
    Abstract: The invention provides peptides designed to be highly reactive with antibodies from patients infected with oncogenic HPV. Also disclosed is a method for their use in an immunoassay to detect HPV infection and HPV associated epithelial cell abnormalities, most notably those associated with premalignant and malignant epithelial cell lesions. The peptides and the disclosed method are particularly useful for diagnosing carcinomas of the uterine cervix, or pre-stages thereof, or those at risk of development of carcinoma. The detection can be effected on blood samples, or other bodily fluid or tissue, by ascertaining the presence of IgA or IgG antibodies against HPV 16 and/or 18.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: June 1, 2004
    Assignee: Impact Diagnostics, Inc.
    Inventor: Yao Xiong Hu
  • Publication number: 20030027750
    Abstract: The invention provides peptides designed to be highly reactive with antibodies from patients infected with oncogenic HPV. Also disclosed is a method for their use in an immunoassay to detect HPV infection and HPV associated epithelial cell abnormalities, most notably those associated with premalignant and malignant epithelial cell lesions. The peptides and the disclosed method are particularly useful for diagnosing carcinomas of the uterine cervix, or pre-stages thereof, or those at risk of development of carcinoma. The detection can be effected on blood samples, or other bodily fluid or tissue, by ascertaining the presence of IgA or IgG antibodies against HPV 16 and/or 18.
    Type: Application
    Filed: April 5, 2001
    Publication date: February 6, 2003
    Inventor: Yao Xiong Hu