Abstract: Disclosed is a coffee machine. The coffee machine includes a water tank, a liquid level stabilization module, a brewing module, a pipeline and a first heating pipe, and the water tank is provided with a water tank outlet; the liquid level stabilization module includes a shell and a float assembly, and the shell is arranged at the water tank outlet, and is provided with a first outlet and a second outlet; the second outlet is communicated with the external environment, and the float assembly is configured to open or close the water tank outlet; the pipeline is connected with the first outlet and the brewing module; the heat element is arranged in the pipeline. The embodiments of the present application can facilitate the outflow of water in the water tank, and at the same time ensure the stability of the flow rate of water in the pipeline.

Abstract: The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.

Abstract: The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.

Abstract: A method of filling a via having a necking point includes performing a pre-clean process to remove residues from an exposed surface of a metal layer at a bottom of a via and recover inner surfaces of the via, wherein the via is formed within a dielectric layer and has a necking point protruding within the via, performing a selective deposition process to partially fill the via with metal fill material from the exposed surface of the metal layer below the necking point, performing a liner deposition process to form a liner layer on exposed inner surfaces of the via, and performing a metal fill process to fill the via with the metal fill material.

Abstract: An antenna structure includes a ground element, a feeding radiation element, a first radiation element, a second radiation element, a shorting radiation element, a third radiation element, and a fourth radiation element. The feeding radiation element has a feeding point. The first radiation element is coupled to the feeding radiation element. The second radiation element is coupled to the feeding radiation element. The second radiation element and the first radiation element substantially extend in opposite directions. The feeding radiation element is further coupled through the shorting radiation element to the ground element. The third radiation element is coupled to the ground element. The third radiation element is adjacent to the first radiation element. The fourth radiation element is coupled to the ground element. The fourth radiation element is adjacent to the second radiation element.

Abstract: A wearable device includes a frame element and a dielectric substrate. The frame element includes a first metal element, a second metal element, and a third metal element. A first gap is provided between the first metal element and the second metal element. A second gap is provided between the second metal element and the third metal element. A third gap is provided between the third metal element and the first metal element. The dielectric substrate is surrounded by the first metal element, the second metal element, and the third metal element. A first antenna element is formed by the first metal element. A second antenna element is formed by the second metal element. A third antenna element is formed by the third metal element.

Abstract: The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.

Abstract: Provided are antibodies and antibody derivatives that bind to GARP (also known as LRRC32 and CPPRDD) and/or GARP/TGF? complexand methods of using the same. In certain embodiments, an anti-GARP/TGF? antibody or antibody derivative provided herein can inhibit a TGF? signal pathway in a target cell.

Abstract: The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.

Abstract: Provided is an anti-B7-H3 antibody or antigen-binding fragment thereof, a pharmaceutical composition containing the anti-B7-H3 antibody or antigen-binding fragment thereof, and an application thereof. The anti-B7-H3 antibody or antigen-binding fragment thereof of the present invention has high affinity and stability, and can be used for preparing antitumor drugs.

Abstract: A dual-purpose sintering furnace including a furnace body having a furnace chamber, a first furnace mouth and a second furnace mouth which are communicated with the furnace chamber, a furnace door hinged to the furnace body and configured for closing the first furnace mouth, a blocking member lap-jointed inside the furnace chamber and configured for blocking the second furnace mouth, a sample stage, an ejection rod fixedly arranged on a sample placement face of the sample stage, a lifting device configured for driving the sample stage to raise or lower, so that the ejection rod pushes the blocking member until the second furnace mouth is opened, and so that the sample stage enters the furnace chamber through the second furnace mouth. The dual-purpose sintering furnace can complete a large amount of sintering as conventional sintering and also implement rapid sintering.

Abstract: A method and apparatus for executing a distributed computing task are provided. The method can include: parsing an expression of the distributed computing task to obtain an operator keyword; and executing, by using an operator corresponding to the operator keyword, the distributed computing task based on an input parameter of the operator, the input parameter of the operator including at least one of: a distributed stored distributed dataset including at least one data element, a distributed stored distributed key-value pair set including at least one key-value pair, and a value of the key-value pair in the distributed key-value pair set being a distributed dataset or a distributed key-value pair set.

Abstract: Embodiments and implementations of the present disclosure provide assistant pattern configuration methods, masks and forming methods thereof, and related devices.

Abstract: A distributed computing framework and a distributed computing method are provided. A specific embodiment of the distributed computing framework includes: a parsing unit, configured to parse an expression of a distributed computing task, and determine an operator and a field corresponding to the operator; and an operator unit, configured to provide the operator, input parameters of the operator including: the field and a field-type distributed dataset. The type of parameters received and returned by any operator may be the field-type distributed dataset, and any operator may operate on the data corresponding to the field in the field-type distributed dataset. Therefore, any operator needs to be implemented once to realize the reuse of the operator. The distributed computing task is expressed in a simple expression, which simplifies the complexity of writing a distributed computing program with the distributed computing framework used by the user.

Abstract: Embodiments and implementations of the present disclosure provide assistant pattern configuration methods, masks and forming methods thereof, and related devices.

Abstract: A method of increasing gene expression by manipulating the circadian clock is described that includes transforming a photosynthetic organism to include an expression control sequence that modulates the expression of a clock gene to increase expression of a target gene. Photosynthetic organism having a modified circadian cycle reflecting this method are also described.

Abstract: The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.

Abstract: A method of increasing gene expression by manipulating the circadian clock is described that includes transforming a photosynthetic organism to include an expression control sequence that modulates the expression of a clock gene to increase expression of a target gene. Photosynthetic organism having a modified circadian cycle reflecting this method are also described.

Abstract: A method and an apparatus are for monitoring the state of a device in process industries and a medium. The method includes: collecting and saving data of the multi-dimensional state of a device in the process industry; performing correlation analysis on the collected historical data of the multi-dimensional state of the device to obtain state dimensions having correlation; acquiring, according to the obtained state dimensions having correlation, historical data of the dimensional states having correlation, and modeling the acquired historical data of the dimensional states to obtain a device state reference model; acquiring real-time data of the dimensional states having correlation corresponding to the device state reference model in real time, and determining whether the current state of the device is normal according to a preset device state determination condition and the acquired real-time data of the dimensional states having correlation, and in combination with the device state reference model.

Abstract: A dual-purpose sintering furnace including a furnace body having a furnace chamber, a first furnace mouth and a second furnace mouth which are communicated with the furnace chamber, a furnace door hinged to the furnace body and configured for closing the first furnace mouth, a blocking member lap jointed inside the furnace chamber and configured for blocking the second furnace mouth, a sample stage, an ejection rod fixedly arranged on a sample placement face of the sample stage, a lifting device configured for driving the sample stage to raise or lower, so that the ejection rod pushes the blocking member until the second furnace mouth is opened, and so that the sample stage enters the furnace chamber through the second furnace mouth. The dual-purpose sintering furnace can complete a large amount of sintering as conventional sintering and also implement rapid sintering.