Abstract: The present application relates to an antibody capable of specifically binding to c-Met or antigen-binding fragment thereof, and an immunoconjugate, a pharmaceutical composition and a multispecific molecule comprising the same. The present application further relates to the use of the antibody specifically binding to c-Met or an antigen-binding fragment thereof and the multispecific molecule. Compared with the control antibody, the bispecific antibody or defucosylated bispecific antibody of the present application can block HGF-dependent TKI resistance; block the proliferation and migration of tumor cells induced by HGF, induce ADCC effect, and inhibit tumor growth in vivo.

Abstract: A light-emitting element, a light-emitting device and a display device are provided, which relate to the technical filed of semiconductor devices. The light-emitting element is a flip-chip light-emitting diode, and has a light-emitting surface and a backlight surface respectively located on outermost sides of the flip-chip light-emitting diode and opposite to each other; the flip-chip light-emitting diode includes an epitaxial staked layer configured to generate predetermined light; and a light-splitting layer disposed on a side of the epitaxial stacked layer proximate to the light-emitting surface; the light-splitting layer is configured to reflect predetermined light with an incident complementary angle of a first angle, transmit predetermined light with an incident complementary angle of a second angle, and reflect predetermined light with an incident complementary angle of a third angle; and the first angle is smaller than the second angle, and the second angle is smaller than the third angle.

Abstract: Provided are an anti-PD-1/anti-HER2 natural antibody structural heterodimeric bispecific antibody and a method of preparing the same. More particularly, provided are a highly stable heterodimeric anti-PD-1/anti-HER2 bispecific antibody having natural IgG characteristics without mismatch between a heavy chain and a light chain, and a method of preparing the same. The bispecific antibody may bind to two target molecules simultaneously and has excellent effects in treatment of a complex disease.

Abstract: A pixel scan drive circuit including a switch unit, a pull-up output unit and a pull-down output unit is provided. In a scan signal output phase of a scanning cycle, the pull-down output unit outputs a first reference voltage in a scan signal to an output end according to a clock signal. In a maintenance phase of the scanning cycle, the switch unit controls the voltage of a pull-down node according to a switch control signal, thereby controlling the pull-down output unit to stop outputting the first reference voltage. In the maintenance phase, the pull-up output unit outputs a second reference voltage in the scan signal. The second reference voltage controls the pixel units to stop receiving the image data. Transistors in the switch unit are of different types from transistors in the pull-up output unit and the pull-down output unit. An array substrate and a display terminal are provided.

Abstract: Provided is a light emitting scanning drive unit (EOA), including a pull-up control unit (11), a pull-up output unit (12), a pull-down control unit (14) and a pull-down output unit (13). When receiving a first clock signal (ECKi), the pull-up control unit (11) transmits the high-level reference voltage to the pull-up node (PU) to control the pull-up point (PU) to be in the high-level state, meanwhile, the pull-up output unit (12) transmits the high-level reference voltage to the light emitting scanning terminal (Oe) when it is in the high-level state and outputs the high-level reference voltage as the light emitting scanning signal.

Abstract: The present invention provides a scanning drive circuit (10), including a pull-down control module (100), a pull-down output module (200), a pull-up control module (300) and an output end (Eout), where a first node (PD) is arranged between the pull-down control module (100) and the pull-down output module (200), the pull-down control module (100) and the pull-down output module (200) are respectively electrically connected to the first node (PD), and the output end (Eout) is configured to be connected to a light-emitting unit. Whether in a data write-in stage or a light-emitting stage, the pull-down control module (100) controls a potential of the first node (PD) which controls an input result input to the output end (Eout) from the pull-down output module (200). So, the light-emitting unit can be controlled to emit light in time, thereby improving a light-emitting display effect. The present invention further provides a display panel.

Abstract: The present disclosure provides a light-emitting scanning signal drive circuit, a display panel and an electronic device. The light-emitting scanning signal drive circuit includes: an enable signal generation circuit and a regulation circuit, where the enable signal generation circuit is configured to receive a first voltage signal and includes a pull-up point, a pull-down point and an output terminal, the pull-up point is electrically connected to the regulation circuit, the pull-down point is electrically connected to the regulation circuit, the regulation circuit is configured to receive a second voltage signal and input the second voltage signal to the enable signal generation circuit, and the enable signal generation circuit generates a high-potential enable signal based on the first voltage signal and the second voltage signal and outputs the high-potential enable signal via the output terminal. The leakage current of the enable signal generation circuit is reduced.

Abstract: A pixel scan drive circuit including a switch unit, a pull-up output unit and a pull-down output unit is provided. In a scan signal output phase of a scanning cycle, the pull-down output unit outputs a first reference voltage in a scan signal to an output end according to a clock signal. In a maintenance phase of the scanning cycle, the switch unit controls the voltage of a pull-down node according to a switch control signal, thereby controlling the pull-down output unit to stop outputting the first reference voltage. In the maintenance phase, the pull-up output unit outputs a second reference voltage in the scan signal. The second reference voltage controls the pixel units to stop receiving the image data. Transistors in the switch unit are of different types from transistors in the pull-up output unit and the pull-down output unit. An array substrate and a display terminal are provided.

Abstract: Provided are an anti-PD-1/anti-HER2 natural antibody structural heterodimeric bispecific antibody and a method of preparing the same. More particularly, provided are a highly stable heterodimeric anti-PD-1/anti-HER2 bispecific antibody having natural IgG characteristics without mismatch between a heavy chain and a light chain, and a method of preparing the same. The bispecific antibody may bind to two target molecules simultaneously and has excellent effects in treatment of a complex disease.

Abstract: The array substrate, the liquid crystal display panel and the liquid crystal display device of the present disclosure are designed to form the MIS storage capacitor by the P—Si semiconductor layer, the first metal layer and the insulating layer between above or the P—Si semiconductor layer, the second metal layer and the dielectric spacer layer between above, when one side of the first metal layer or the second metal layer receiving the negative gray voltage, the P—Si in the P—Si semiconductor layer will gather to form the hole, when receiving the positive gray voltage, will form the depletion layer on the upper layer of the P—Si to reduce the capacity of the MIS storage capacitor, thereby reducing the difference of the capacitance when the MIS storage capacitor in the positive and negative gray voltage, improving the flicker phenomena and ensuring the display effect.

Abstract: The array substrate, the liquid crystal display panel and the liquid crystal display device of the present disclosure are designed to form the MIS storage capacitor by the P—Si semiconductor layer, the first metal layer and the insulating layer between above or the P—Si semiconductor layer, the second metal layer and the dielectric spacer layer between above, when one side of the first metal layer or the second metal layer receiving the negative gray voltage, the P—Si in the P—Si semiconductor layer will gather to form the hole, when receiving the positive gray voltage, will form the depletion layer on the upper layer of the P—Si to reduce the capacity of the MIS storage capacitor, thereby reducing the difference of the capacitance when the MIS storage capacitor in the positive and negative gray voltage, improving the flicker phenomena and ensuring the display effect.

Abstract: The array substrate, the liquid crystal display panel and the liquid crystal display device of the present disclosure are designed to from the MIS storage capacitor by the P-Si semiconductor layer, the first metal layer and the insulating layer between above or the P-Si semiconductor layer, the second metal layer and the dielectric spacer layer between above, when one side of the first metal layer or the second metal layer receiving the negative gray voltage, the P-Si in the P-Si semiconductor layer will gather to form the hole, when receiving the positive gray voltage, will form the depletion layer on the upper layer of the P-Si to reduce the capacity of the MIS storage capacitor, thereby reducing the difference of the capacitance when the MIS storage capacitor in the positive and negative gray voltage, improving the flicker phenomena and ensuring the display effect.

Abstract: A GOA circuit, a display device, and a driving method of GOA circuit are disclosed. A N-th level GOA unit is configured for charging the N-th level horizontal scanning line (G(N)) within a display area of the display device. The N-th level horizontal scanning line (G(N)) connects to GAS. In response to the GAS, the horizontal scanning lines corresponding to all of the GOA units are in a charging state. In this way, the horizontal scanning lines at each level are connected to the GAS, such that when the GAS are valid, the corresponding horizontal scanning line at each level are in the charging state of in an on-state so as to realize the All Gate On function.

Abstract: The array substrate, the liquid crystal display panel and the liquid crystal display device of the present disclosure are designed to form the MIS storage capacitor by the P—Si semiconductor layer, the first metal layer and the insulating layer between above or the P—Si semiconductor layer, the second metal layer and the dielectric spacer layer between above, when one side of the first metal layer or the second metal layer receiving the negative gray voltage, the P—Si in the P—Si semiconductor layer will gather to form the hole, when receiving the positive gray voltage, will form the depletion layer on the upper layer of the P—Si to reduce the capacity of the MIS storage capacitor, thereby reducing the difference of the capacitance when the MIS storage capacitor in the positive and negative gray voltage, improving the flicker phenomena and ensuring the display effect.

Abstract: The array substrate, the liquid crystal display panel and the liquid crystal display device of the present disclosure are designed to form the MIS storage capacitor by the P—Si semiconductor layer, the first metal layer and the insulating layer between above or the P—Si semiconductor layer, the second metal layer and the dielectric spacer layer between above, when one side of the first metal layer or the second metal layer receiving the negative gray voltage, the P—Si in the P—Si semiconductor layer will gather to form the hole, when receiving the positive gray voltage, will form the depletion layer on the upper layer of the P—Si to reduce the capacity of the MIS storage capacitor, thereby reducing the difference of the capacitance when the MIS storage capacitor in the positive and negative gray voltage, improving the flicker phenomena and ensuring the display effect.

Abstract: The array substrate, the liquid crystal display panel and the liquid crystal display device of the present disclosure are designed to from the MIS storage capacitor by the P-Si semiconductor layer, the first metal layer and the insulating layer between above or the P-Si semiconductor layer, the second metal layer and the dielectric spacer layer between above, when one side of the first metal layer or the second metal layer receiving the negative gray voltage, the P-Si in the P-Si semiconductor layer will gather to form the hole, when receiving the positive gray voltage, will form the depletion layer on the upper layer of the P-Si to reduce the capacity of the MIS storage capacitor, thereby reducing the difference of the capacitance when the MIS storage capacitor in the positive and negative gray voltage, improving the flicker phenomena and ensuring the display effect.

Abstract: A gate on array (GOA) circuit for used in an LCD includes GOA units connected in cascade. An Nth GOA unit includes an Nth stage-transmittance circuit, an Nth Q-node controlling circuit, an Nth P-node controlling circuit, an Nth outputting circuit, and a first switch circuit where N is a positive integer. The first switch circuit connected to the Nth scanning line, for inputting an enabling signal to the Nth scanning line before the LCD shows images so as to turn on a TFT in a pixel which the Nth scanning line is connected to. The benefit of the function is that the display does not leak electricity when the black screen is woken up and that the stability of the circuit is enhanced at the same time.

Abstract: The array substrate, the liquid crystal display panel and the liquid crystal display device of the present disclosure are designed to from the MIS storage capacitor by the P—Si semiconductor layer, the first metal layer and the insulating layer between above or the P—Si semiconductor layer, the second metal layer and the dielectric spacer layer between above, when one side of the first metal layer or the second metal layer receiving the negative gray voltage, the P—Si in the P—Si semiconductor layer will gather to form the hole, when receiving the positive gray voltage, will form the depletion layer on the upper layer of the P—Si to reduce the capacity of the MIS storage capacitor, thereby reducing the difference of the capacitance when the MIS storage capacitor in the positive and negative gray voltage, improving the flicker phenomena and ensuring the display effect.

Abstract: The disclosure provides a GOA circuit, a driving method thereof and a liquid crystal display device. The GOA circuit comprises a plurality of GOA units connected in cascade, wherein the N-stage GOA unit comprises a N-stage stage circuit, a N-stage Q point control circuit, a N-stage P point circuit, a N-stage output circuit and a switch circuit. The switch circuit is connected to the N-stage scan line for sending a turn-on signal to the N-stage scan line before the liquid crystal display device displays an image such that the thin-film transistor in the pixel connected to the N-stage scan line turns on. The disclosure may turn on the gate of each pixel when the display device is waken from the black screen to prevent the electricity leakage when the display device is wakened from the black screen, and may also increase the stability of the circuit.

Abstract: The present invention provides a GOA circuit, comprising a forward-backward scan control module, an output module, an output pull-down module, a node control module, a second node signal input module, a second node signal control module, a voltage stabilizing module and a second capacitor; the forward scan of the circuit is controlled with the ninth and the tenth thin film transistors, and the signal input of the second node is controlled with the first and the eleventh thin film transistors, and the mutual control of the first node and the second node are achieved with the second, the fourth and the fifth thin film transistors, and meanwhile, as the GOA circuit applies to a display of dual side drive interlaced scan structure, the GOA circuits of the two sides can respectively receive four different clock signals to reduce the loading of the signal line of the GOA circuit.