Abstract: Disclosed herein is a microfiltration device comprising a microfilter coated with a positively-charged degradable layer and a method of preparing the microfiltration device as described herein. Disclosed herein is also a method of separating a biological material using the microfiltration device as described herein and a kit comprising the microfiltration device as described herein. The microfiltration device and method of separating a biological material described herein demonstrates good compatibility with various downstream analysis techniques.

Abstract: A container for processing a fluid biological sample, including a container body including at least a first compartment for accommodating a first fluid and a second compartment for accommodating a second fluid, an interconnecting fluid pathway for providing a fluid communication between the first and second compartments, an inner shutter arranged so as to be movable between a first position where it blocks the interconnecting fluid pathway and a second position where it allows the fluid communication through the interconnecting fluid pathway, and a first cover arranged to allow selective access from outside the container to introduce the sample into at least one of the first and second compartments and to seal the fluid within the container body, preferably in conjunction with the inner shutter. A kit for treatment of a fluid biological sample using this container is also provided.