Patents by Inventor Yaoqiu Zhu

Yaoqiu Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHEMICAL SYNTHESIS OF CLOPIDOGREL ACTIVE METABOLITES AND DISULFIDE CONJUGATE PRODRUGS
    Publication number: 20230201182
    Abstract: A method of synthesizing a clopidogrel metabolite is provided. A piperidone intermediate is formed from a mandelate. An asymmetric ketone reduction of the piperidone intermediate is performed. A mercapto installation is performed on the piperidone intermediate to form a clopidogrel metabolite that includes a 4-carbon chiral center having an (R) configuration.
    Type: Application
    Filed: February 28, 2023
    Publication date: June 29, 2023
    Inventor: Yaoqiu Zhu
  • Chemical synthesis of clopidogrel active metabolites and disulfide conjugate prodrugs
    Patent number: 11642335
    Abstract: A method of synthesizing a clopidogrel metabolite is provided. A piperidone intermediate is formed from a mandelate. An asymmetric ketone reduction of the piperidone intermediate is performed. A mercapto installation is performed on the piperidone intermediate to form a clopidogrel metabolite that includes a 4-carbon chiral center having an (R) configuration.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: May 9, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventor: Yaoqiu Zhu
  • Chemical Synthesis of Clopidogrel Active Metabolites and Disulfide Conjugate Prodrugs
    Publication number: 20210093624
    Abstract: A method of synthesizing a clopidogrel metabolite is provided. A piperidone intermediate is formed from a mandelate. An asymmetric ketone reduction of the piperidone intermediate is performed. A mercapto installation is performed on the piperidone intermediate to form a clopidogrel metabolite that includes a 4-carbon chiral center having an (R) configuration.
    Type: Application
    Filed: September 28, 2020
    Publication date: April 1, 2021
    Inventor: Yaoqiu Zhu