Patents by Inventor Yaoyao YAN

Yaoyao YAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRIMIDINE-2,4-DIAMINE COMPOUND AND PREPAREATION METHOD AND APPLICATION THEREOF
    Publication number: 20230150947
    Abstract: A pyrimidine-2,4-diamine compound and a preparation method and application thereof are provided. The pyrimidine-2,4-diamine compound of the present disclosure can be used in the research of biological or pharmacological phenomena and cathepsin C-involved signal pathway transduction and the evaluation of novel cathepsin C inhibitors. The pyrimidine-2,4-diamine compound is subjected to the screening of anti-cathepsin C activity in vitro and in vivo and proved to have strong inhibitory activity on cathepsin C. The pyrimidine-2,4-diamine compound is subjected to the screening of anti-NSP activity in vivo and proved to have strong inhibitory activity on NSP. The pyrimidine-2,4-diamine compound is subjected to the screening of anti-inflammatory activity in vivo and proved to have an effective therapeutic effect on inflammatory disease models. Meanwhile, the pyrimidine-2,4-diamine compound shows low toxicity and exhibits good application prospect.
    Type: Application
    Filed: January 21, 2022
    Publication date: May 18, 2023
    Applicant: ANHUI MEDICAL UNIVERSITY
    Inventors: Xinhua LIU, Xing CHEN, Jingbo SHI, Mingming LIU, Yaoyao YAN, Zhaoyan ZHANG, Famin ZHANG