Abstract: Described herein are compounds that inhibit galactokinase (GALK) and other kinases and methods for producing the same. Also described are methods for using Structure-Activity Relationships (SAR) to develop compounds with enhanced activity.

Abstract: Multiple schemes and techniques for facilitating presentations with an interactive application are described. For example, an interactive application provides a console view overlay for integrating multiple productivity applications into a graphical user interface (GUI) window. An interactive application can also share a selected display portion of the console view overlay with other interactive applications. As another example, presenters and other audience members can draw on the selected display portion being shared, and the drawn graphics are synchronously displayed by the other interactive applications. Interactive applications, as directed by their users, can join various member groups and specific presentations thereof. Moreover, a user may share content in accordance with membership grouping.

Abstract: Disclosed herein are methods of treating a malignant adrenocortical tumor, including a locally advanced and metastatic adrenocortical carcinoma. In some examples, methods of treating a malignant adrenocortical tumor include administering an effective amount of niclosamide alone or in combination with other therapeutic agents to a subject in need thereof, thereby treating the malignant adrenocortical tumor.

Abstract: Multiple schemes and techniques for facilitating presentations with an interactive application are described. For example, an interactive application provides a console view overlay for integrating multiple productivity applications into a graphical user interface (GUI) window. An interactive application can also share a selected display portion of the console view overlay with other interactive applications. As another example, presenters and other audience members can draw on the selected display portion being shared, and the drawn graphics are synchronously displayed by the other interactive applications. Interactive applications, as directed by their users, can join various member groups and specific presentations thereof. Moreover, a user may share content in accordance with membership grouping.

Abstract: Multiple schemes and techniques for facilitating presentations with an interactive application are described. For example, an interactive application provides a console view overlay for integrating multiple productivity applications into a graphical user interface (GUI) window. An interactive application can also share a selected display portion of the console view overlay with other interactive applications. As another example, presenters and other audience members can draw on the selected display portion being shared, and the drawn graphics are synchronously displayed by the other interactive applications. Interactive applications, as directed by their users, can join various member groups and specific presentations thereof. Moreover, a user may share content in accordance with membership grouping.

Abstract: Small molecule inhibitors of Nrf2 and methods of their use are provided for treating or preventing a disease, disorder or condition associated with an Nrf2-regulated pathway. The compound can be administered as a single agent or can be administered to enhance the efficacy of a chemotherapeutic drug and/or radiation therapy.

Abstract: A seamless bitstream switching schema is presented. The schema takes advantage of both the high coding efficiency of non-scalable bitstreams and the flexibility of scalable bitstreams. Small bandwidth fluctuations are accommodated by the scalability of the bitstreams, while large bandwidth fluctuations are tolerated by switching among scalable bitstreams. This seamless bitstream switching schema significantly improves the efficiency of scalable video coding over a broad range of bit rates.

Abstract: A video coding system and method utilizes a 3-D wavelet transform that is memory efficient and reduces boundary effect across frame boundaries. The transform employs a lifting-based scheme and buffers wavelet coefficients at intermediate lifting steps towards the end of one GOP (group of pictures) until intermediate coefficients from the beginning of the next GOP are available. The wavelet transform scheme does not physically break the video sequence into GOPs, but processes the sequence without intermission. In this manner, the system simulates an infinite wavelet transformation across frame boundaries and the boundary effect is significantly reduced or essentially eliminated. Moreover, the buffering is very small and the scheme can be used to implement other decomposition structures. The wavelet transform scheme provides superb video playback quality with little or no boundary effects.

Abstract: A seamless bitstream switching schema is presented. The schema takes advantage of both the high coding efficiency of non-scalable bitstreams and the flexibility of scalable bitstreams. Small bandwidth fluctuations are accommodated by the scalability of the bitstreams, while large bandwidth fluctuations are tolerated by switching among scalable bitstreams. This seamless bitstream switching schema significantly improves the efficiency of scalable video coding over a broad range of bit rates.

Abstract: A scalable layered video coding scheme that encodes video data frames into multiple layers, including a base layer of comparatively low quality video and multiple enhancement layers of increasingly higher quality video, adds error resilience to the enhancement layer. Unique resynchronization marks are inserted into the enhancement layer bitstream in headers associated with each video packet, headers associated with each bit plane, and headers associated with each video-of-plane (VOP) segment. Following transmission of the enhancement layer bitstream, the decoder tries to detect errors in the packets. Upon detection, the decoder seeks forward in the bitstream for the next known resynchronization mark. Once this mark is found, the decoder is able to begin decoding the next video packet. With the addition of many resynchronization marks within each frame, the decoder can recover very quickly and with minimal data loss in the event of a packet loss or channel error in the received enhancement layer bitstream.

Abstract: Multiple schemes and techniques for facilitating presentations with an interactive application are described. For example, an interactive application provides a console view overlay for integrating multiple productivity applications into a graphical user interface (GUI) window. An interactive application can also share a selected display portion of the console view overlay with other interactive applications. As another example, presenters and other audience members can draw on the selected display portion being shared, and the drawn graphics are synchronously displayed by the other interactive applications. Interactive applications, as directed by their users, can join various member groups and specific presentations thereof. Moreover, a user may share content in accordance with membership grouping.

Abstract: A scalable layered video coding scheme that encodes video data frames into multiple layers, including a base layer of comparatively low quality video and multiple enhancement layers of increasingly higher quality video, adds error resilience to the enhancement layer. Unique resynchronization marks are inserted into the enhancement layer bitstream in headers associated with each video packet, headers associated with each bit plane, and headers associated with each video-of-plane (VOP) segment. Following transmission of the enhancement layer bitstream, the decoder tries to detect errors in the packets. Upon detection, the decoder seeks forward in the bitstream for the next known resynchronization mark. Once this mark is found, the decoder is able to begin decoding the next video packet. With the addition of many resynchronization marks within each frame, the decoder can recover very quickly and with minimal data loss in the event of a packet loss or channel error in the received enhancement layer bitstream.

Abstract: A scalable layered video coding scheme that encodes video data frames into multiple layers, including a base layer of comparatively low quality video and multiple enhancement layers of increasingly higher quality video, adds error resilience to the enhancement layer. Unique resynchronization marks are inserted into the enhancement layer bitstream in headers associated with each video packet, headers associated with each bit plane, and headers associated with each video-of-plane (VOP) segment. Following transmission of the enhancement layer bitstream, the decoder tries to detect errors in the packets. Upon detection, the decoder seeks forward in the bitstream for the next known resynchronization mark. Once this mark is found, the decoder is able to begin decoding the next video packet. With the addition of many resynchronization marks within each frame, the decoder can recover very quickly and with minimal data loss in the event of a packet loss or channel error in the received enhancement layer bitstream.

Abstract: A scalable layered video coding scheme that encodes video data frames into multiple layers, including a base layer of comparatively low quality video and multiple enhancement layers of increasingly higher quality video, adds error resilience to the enhancement layer. Unique resynchronization marks are inserted into the enhancement layer bitstream in headers associated with each video packet, headers associated with each bit plane, and headers associated with each video-of-plane (VOP) segment. Following transmission of the enhancement layer bitstream, the decoder tries to detect errors in the packets. Upon detection, the decoder seeks forward in the bitstream for the next known resynchronization mark. Once this mark is found, the decoder is able to begin decoding the next video packet. With the addition of many resynchronization marks within each frame, the decoder can recover very quickly and with minimal data loss in the event of a packet loss or channel error in the received enhancement layer bitstream.

Abstract: A video encoding system and method utilizes a three-dimensional (3-D) wavelet transform and entropy coding that utilize motion information in a way to reduce the sensitivity to motion. In one implementation, the coding process initially estimates motion trajectories of pixels in a video object from frame to frame in a video sequence to account for motion of the video object throughout the frames. After motion estimation, a 3-D wavelet transform is applied in two parts. First, a temporal 1-D wavelet transform is applied to the corresponding pixels along the motion trajectories in a time direction. The temporal wavelet transform produces decomposed frames of temporal wavelet transforms, where the spatial correlation within each frame is well preserved. Second, a spatial 2-D wavelet transform is applied to all frames containing the temporal wavelet coefficients. The wavelet transforms produce coefficients within different sub-bands. The process then codes wavelet coefficients.

Abstract: A video encoding system and method utilizes a three-dimensional (3-D) wavelet transform and entropy coding that utilize motion information in a way to reduce the sensitivity to motion. In one implementation, the coding process initially estimates motion trajectories of pixels in a video object from frame to frame in a video sequence to account for motion of the video object throughout the frames. After motion estimation, a wavelet transform is applied to produce coefficients within different sub-bands. The wavelet coefficients are coded independently for each sub-band to permit easy separation at a decoder, making resolution scalability and temporal scalability natural and easy. In particular, the coefficients are assigned various contexts based on the significance of neighboring samples in previous, current, and next frame, thereby taking advantage of any motion information between frames.

Abstract: A video encoding system and method utilizes a three-dimensional (3-D) wavelet transform and entropy coding that utilize motion information in a way to reduce the sensitivity to motion. In one implementation, the coding process initially estimates motion trajectories of pixels in a video object from frame to frame in a video sequence to account for motion of the video object throughout the frames. After motion estimation, a 3-D wavelet transform is applied in two parts. First, a temporal 1-D wavelet transform is applied to the corresponding pixels along the motion trajectories in a time direction. The temporal wavelet transform produces decomposed frames of temporal wavelet transforms, where the spatial correlation within each frame is well preserved. Second, a spatial 2-D wavelet transform is applied to all frames containing the temporal wavelet coefficients. The wavelet transforms produce coefficients within different sub-bands. The process then codes wavelet coefficients.

Abstract: A scalable layered video coding scheme that encodes video data frames into multiple layers, including a base layer of comparatively low quality video and multiple enhancement layers of increasingly higher quality video, adds error resilience to the enhancement layer. Unique resynchronization marks are inserted into the enhancement layer bitstream in headers associated with each video packet, headers associated with each bit plane, and headers associated with each video-of-plane (VOP) segment. Following transmission of the enhancement layer bitstream, the decoder tries to detect errors in the packets. Upon detection, the decoder seeks forward in the bitstream for the next known resynchronization mark. Once this mark is found, the decoder is able to begin decoding the next video packet. With the addition of many resynchronization marks within each frame, the decoder can recover very quickly and with minimal data loss in the event of a packet loss or channel error in the received enhancement layer bitstream.

Abstract: A video encoding system and method utilizes a three-dimensional (3-D) wavelet transform and entropy coding that utilize motion information in a way to reduce the sensitivity to motion. In one implementation, the coding process initially estimates motion trajectories of pixels in a video object from frame to frame in a video sequence to account for motion of the video object throughout the frames. After motion estimation, a 3-D wavelet transform is applied in two parts. First, a temporal 1-D wavelet transform is applied to the corresponding pixels along the motion trajectories in a time direction. The temporal wavelet transform produces decomposed frames of temporal wavelet transforms, where the spatial correlation within each frame is well preserved. Second, a spatial 2-D wavelet transform is applied to all frames containing the temporal wavelet coefficients. The wavelet transforms produce coefficients within different sub-bands. The process then codes wavelet coefficients.

Abstract: An accelerated video decoding system utilizes a graphics processing unit to perform motion compensation, image reconstruction, and color space conversion processes, while utilizing a central processing unit to perform other decoding processes.