Patents by Inventor Yarden Opatowsky

Yarden Opatowsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Roundabout (Robo) receptor inhibitors and uses thereof
    Patent number: 11406682
    Abstract: The present invention, in some embodiments thereof, relates to inhibitory compositions binding to the ectodomain of a Roundabout (Robo) receptor and to the use of same for downregulating Robo-mediated signaling. In particular, the present invention provides moieties that bind to and prevent dimerization of an Ig-like Robo receptor ectodomain, thereby inhibiting Robo receptor activity.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: August 9, 2022
    Assignee: Bar-Ilan University
    Inventors: Yarden Opatowsky, Reut Barak-Fucks, Julia Guez-Haddad, Galit Yom-Tov
  • METHODS FOR THE IDENTIFICATION OF SARM1 NADASE ACTIVITY INHIBITORS AND USES THEREOF
    Publication number: 20220241416
    Abstract: The present disclosure provides screening methods for identifying a sterile ? and HEAT/armadillo motif-containing protein-1 (SARM1) NADase modulator, specifically, inhibitor, using at least one full length or near full length catalytically active SARM1 or any fragment or variant thereof. The present disclosure further provides SARM inhibitors identified by the screening methods, and therapeutic compositions and methods for treating, conditions or disorders associated directly or indirectly with axonal and/or cellular degradation.
    Type: Application
    Filed: January 27, 2022
    Publication date: August 4, 2022
    Inventor: Yarden OPATOWSKY
  • ROUNDABOUT (ROBO) RECEPTOR INHIBITORS AND USES THEREOF
    Publication number: 20200353030
    Abstract: The present invention, in some embodiments thereof, relates to inhibitory compositions binding to the ectodomain of a Roundabout (Robo) receptor and to the use of same for downregulating Robo-mediated signaling. In particular, the present invention provides moieties that bind to and prevent dimerization of an Ig-like Robo receptor ectodomain, thereby inhibiting Robo receptor activity.
    Type: Application
    Filed: August 24, 2018
    Publication date: November 12, 2020
    Applicant: Bar-Ilan University
    Inventors: Yarden OPATOWSKY, Reut BARAK-FUCKS, Julia GUEZ-HADDAD, Galit YOM-TOV
  • ANTIMICROBIAL COMPOSITIONS AND METHODS AND USES THEREOF
    Publication number: 20170064966
    Abstract: The invention relates to inhibitors of a bacterial biofilm formation that target the N? loop extension of the periplasmic subunit of a bacterial Phosphate Specific Transfer system (PstS), specifically, of P. aeruginosa. The inhibitors of the invention may be either derived from the N? loop extension of PstS or directed against the N? loop extension. The invention further provides compositions and methods using said inhibitors in inhibiting biofilm formation and in treating pathologic conditions associated therewith.
    Type: Application
    Filed: September 7, 2016
    Publication date: March 9, 2017
    Applicant: BAR ILAN UNIVERSITY
    Inventors: Yarden OPATOWSKY, Ehud BANIN, Avi NEZNANSKY, Inna BLUS-KADOSH, Gal YERUSHALMI
  • Inhibitors of receptor tyrosine kinases and methods of use thereof
    Patent number: 9273134
    Abstract: The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: March 1, 2016
    Assignee: Yale University
    Inventors: Joseph Schlessinger, Irit Lax, Satoru Yuzawa, Yarden Opatowsky, Yan Yang
  • INHIBITORS OF RECEPTOR TYROSINE KINASES AND METHODS OF USE THEREOF
    Publication number: 20110311538
    Abstract: The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.
    Type: Application
    Filed: June 5, 2008
    Publication date: December 22, 2011
    Applicant: YALE UNIVERSITY
    Inventors: Joseph Schlessinger, Irit Lax, Satoru Yuzawa, Yarden Opatowsky, Yan Yang