Patents by Inventor Yared Tekabe

Yared Tekabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vivo imaging of matrix metalloproteinases in lung disease
    Patent number: 11565004
    Abstract: The present invention provides a method of imaging a subject's lung which comprises contacting the subject's lung with a matrix metalloproteinase inhibitor labeled with a radioisotope under conditions such that the inhibitor binds to matrix metalloproteinase in the lung, and then imaging the radiolabeled inhibitor bound to matrix metalloproteinase in the subject's lung. The invention also provides Ro 32-3555 labeled with a radioisotope.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: January 31, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Jeanine D'Armiento, Lynne Johnson, Monica Goldklang, Yared Tekabe
  • IN VIVO IMAGING OF MATRIX METALLOPROTEINASES IN LUNG DISEASE
    Publication number: 20210008231
    Abstract: The present invention provides a method of imaging a subject's lung which comprises contacting the subject's lung with a matrix metalloproteinase inhibitor labeled with a radioisotope under conditions such that the inhibitor binds to matrix metalloproteinase in the lung, and then imaging the radiolabeled inhibitor bound to matrix metalloproteinase in the subject's lung. The invention also provides Ro 32-3555 labeled with a radioisotope.
    Type: Application
    Filed: May 19, 2017
    Publication date: January 14, 2021
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jeanine D'ARMIENTO, Lynne JOHNSON, Monica GOLDKLANG, Yared TEKABE
  • Humanized anti-rage antibody
    Patent number: 10550184
    Abstract: This invention provides a humanized, anti-human receptor for advance glycation end-products (RAGE) monoclonal antibody or a fragment of such antibody which binds human RAGE as well as compositions containing, and uses of, such antibody and fragments.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: February 4, 2020
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Yared Tekabe, Lynne Johnson
  • HUMANIZED ANTI-RAGE ANTIBODY
    Publication number: 20190119378
    Abstract: This invention provides a humanized, anti-human receptor for advance glycation end-products (RAGE) monoclonal antibody or a fragment of such antibody which binds human RAGE as well as compositions containing, and uses of, such antibody and fragments.
    Type: Application
    Filed: April 11, 2017
    Publication date: April 25, 2019
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Yared Tekabe, Lynne Johnson
  • ANTIBODY TO RAGE AND USES FOR IN VIVO IMAGING OR FOR TARGETING THERAPY
    Publication number: 20110311448
    Abstract: This invention discloses an antibody which is raised to a peptide, the sequence of which is: N-R-N-G-K-E-T-K-S-N-Y-R-V-R-V-Y-Q-I-P, N-R-R-G-K-E-V-K-S-N-Y-R-V-R-V-Y-Q-I-P, S-R-N-G-K-E-T-K-S-N-Y-R-V-Q-V-Y-Q-I-P, N-R-R-G-K-E-V-K-S-N-Y-R-V-R-V-Y-Q-I-C, or Ac-N-R-R-G-K-E-V-K-S-N-Y-R-V-R-V-Y-Q-I-C-amide. This antibody can be labeled with an imageable marker or linked to an agent. This antibody can be a monoclonal antibody. The invention also includes a method for determining the location of receptor advanced glycation endproduct (RAGE) in a subject comprising administering the antibody labeled with an imageable marker and detecting the location of the labeled antibody in the subject thereby determining the location of RAGE in the subject. This invention further describes a method for treating a RAGE-related disorder in a subject comprising administering to the subject a therapeutically effective amount of the antibody which binds to the above-described epitope linked to an agent.
    Type: Application
    Filed: October 31, 2008
    Publication date: December 22, 2011
    Inventors: Ann Marie Schmidt, Lynne Johnson, Barry Hudson, Yared Tekabe