Patents by Inventor Yariv Kanfi
Yariv Kanfi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11278525Abstract: A SIRT6 activating molecule as shown in Tables 1-3 and 9, or a compound according to a pharmacophore as described herein.Type: GrantFiled: October 15, 2018Date of Patent: March 22, 2022Assignee: SirTLab CorporationInventors: Haim Yosef Cohen, Yariv Kanfi
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Patent number: 10857170Abstract: A SIRT6 activating molecule as shown in Tables 1-3 or a compound according to a pharmacophore as described herein.Type: GrantFiled: December 30, 2016Date of Patent: December 8, 2020Assignee: SirTLab CorporationInventors: Haim Yosef Cohen, Yariv Kanfi
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Patent number: 10036023Abstract: An aspect of an embodiment of the invention relates to providing treatment of disease, in particular age-related disease, through increasing or decreasing the activity of SIRT6 protein. This may be accomplished through upregulation and downregulation of expression of SIRT6 in mammals. It has been found by the inventors that mice over-expressing SIRT6 have a longer lifespan in comparison to control mice, indicating that increasing SIRT6 expression can lengthen lifespan of mammals. Agents which modulate SIRT6 expression through, for example binding to 3?UTR region of human mRNA encoding SIRT6 or by blocking binding of agents to 3?UTR region of human mRNA encoding SIRT6, have been identified.Type: GrantFiled: April 27, 2017Date of Patent: July 31, 2018Assignee: BAR-ILAN UNIVERSITYInventors: Haim Cohen, Yariv Kanfi, Sivan Elhanati
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Publication number: 20170233744Abstract: An aspect of an embodiment of the invention relates to providing treatment of disease, in particular age-related disease, through increasing or decreasing the activity of SIRT6 protein. This may be accomplished through upregulation and downregulation of expression of SIRT6 in mammals. It has been found by the inventors that mice over-expressing SIRT6 have a longer lifespan in comparison to control mice, indicating that increasing SIRT6 expression can lengthen lifespan of mammals. Agents which modulate SIRT6 expression through, for example binding to 3?UTR region of human mRNA encoding SIRT6 or by blocking binding of agents to 3?UTR region of human mRNA encoding SIRT6, have been identified.Type: ApplicationFiled: April 27, 2017Publication date: August 17, 2017Inventors: Haim COHEN, Yariv KANFI, Sivan ELHANATI
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Patent number: 9650637Abstract: An aspect of an embodiment of the invention relates to providing treatment of disease, in particular age-related disease, through increasing or decreasing the activity of SIRT6 protein. This may be accomplished through upregulation and downregulation of expression of SIRT6 in mammals. It has been found by the inventors that mice over-expressing SIRT6 have a longer lifespan in comparison to control mice, indicating that increasing SIRT6 expression can lengthen lifespan of mammals. Agents which modulate SIRT6 expression through, for example binding to 3?UTR region of human mRNA encoding SIRT6 or by blocking binding of agents to 3?UTR region of human mRNA encoding SIRT6, have been identified.Type: GrantFiled: August 22, 2016Date of Patent: May 16, 2017Assignee: BAR-ILAN UNIVERSITYInventors: Haim Cohen, Yariv Kanfi, Sivan Elhanati
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Publication number: 20160355825Abstract: An aspect of an embodiment of the invention relates to providing treatment of disease, in particular age-related disease, through increasing or decreasing the activity of SIRT6 protein. This may be accomplished through upregulation and downregulation of expression of SIRT6 in mammals. It has been found by the inventors that mice over-expressing SIRT6 have a longer lifespan in comparison to control mice, indicating that increasing SIRT6 expression can lengthen lifespan of mammals. Agents which modulate SIRT6 expression through, for example binding to 3?UTR region of human mRNA encoding SIRT6 or by blocking binding of agents to 3?UTR region of human mRNA encoding SIRT6, have been identified.Type: ApplicationFiled: August 22, 2016Publication date: December 8, 2016Inventors: Haim COHEN, Yariv KANFI, Sivan ELHANATI
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Patent number: 9422561Abstract: An aspect of an embodiment of the invention relates to providing treatment of disease, in particular age-related disease, through increasing or decreasing the activity of SIRT6 protein. This may be accomplished through upregulation and downregulation of expression of SIRT6 in mammals. It has been found by the inventors that mice over-expressing SIRT6 have a longer lifespan in comparison to control mice, indicating that increasing SIRT6 expression can lengthen lifespan of mammals. Agents which modulate SIRT6 expression through, for example binding to 3?UTR region of human mRNA encoding SIRT6 or by blocking binding of agents to 3?UTR region of human mRNA encoding SIRT6, have been identified.Type: GrantFiled: January 24, 2013Date of Patent: August 23, 2016Assignee: BAR-ILAN UNIVERSITYInventors: Haim Cohen, Yariv Kanfi, Sivan Elhanati
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Publication number: 20150018405Abstract: An aspect of an embodiment of the invention relates to providing treatment of disease, in particular age-related disease, through increasing or decreasing the activity of SIRT6 protein. This may be accomplished through upregulation and downregulation of expression of SIRT6 in mammals. It has been found by the inventors that mice over-expressing SIRT6 have a longer lifespan in comparison to control mice, indicating that increasing SIRT6 expression can lengthen lifespan of mammals. Agents which modulate SIRT6 expression through, for example binding to 3?UTR region of human mRNA encoding SIRT6 or by blocking binding of agents to 3?UTR region of human mRNA encoding SIRT6, have been identified.Type: ApplicationFiled: January 24, 2013Publication date: January 15, 2015Inventors: Haim Cohen, Yariv Kanfi, Sivan Elhanati
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Publication number: 20090220486Abstract: The present invention provides antibodies or fragments thereof that bind to cancer cells and is important in physiological phenomena, such as cell rolling and metastasis. Therapeutic and diagnostic methods and compositions using such antibody fragments thereof are also provided. The methods and compositions according to the present invention can be used in targeting therapeutic agents and in diagnosis, prognosis, and staging of and therapy for such diseases as cancer, including tumor growth and metastasis, leukemia, auto-immune disease, and inflammatory disease. Also provided is a library of immunoglobulin binding domains having a diverse antigen-binding domain for complementary binding, wherein the library has diversity only in heavy chain CDR3.Type: ApplicationFiled: January 8, 2008Publication date: September 3, 2009Inventors: Daniel Plaksin, Avigdor Levanon, Esther Szanton, Yocheved Hagay, Rachel Ben-Levy, Yael Nisgav, Yariv Kanfi
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Publication number: 20080274100Abstract: The present invention provides antibodies or fragments thereof that bind to co-receptor CCR5 or CXCR4.Type: ApplicationFiled: January 3, 2008Publication date: November 6, 2008Inventors: Rachel Ben-Levy, Yael Nisgav, Yariv Kanfi
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Publication number: 20050266009Abstract: The present invention provides antibodies or fragments thereof that bind to co-receptor CCR5 or CXCR4.Type: ApplicationFiled: June 27, 2005Publication date: December 1, 2005Inventors: Daniel Plaksin, Avigdor Levanon, Esther Szanton, Yocheved Hagay, Rachel Ben-Levy, Yael Nisgav, Yariv Kanfi
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Publication number: 20050152906Abstract: The present invention provides antibodies that bind an epitope of PSGL-1 comprising the motif D-X-Y-D, wherein X represents any amino acid or the covalent linkage between D and Y, and Y is sulfated, which antibody can be complexed with one or more copies of an agent. The antibodies of the invention can be used in a method of inducing antibody-dependent cell cytotoxicity and/or stimulating natural killer (NK) cells or T cells. In addition, by administering these antibodies to a patient in need thereof, a method of inducing cell death is provided. A method of preventing infection by a virus (e.g., HIV) by administering to a patient in need thereof an antibody of the present invention is also provided. The, present invention also provides a method of introducing an agent into a cell that expresses sulfated PSGL-1 by coupling or complexing an agent to an antibody of the present invention and administering the complex to the cell.Type: ApplicationFiled: June 30, 2004Publication date: July 14, 2005Inventors: Avigdor Levanon, Tikva Vogel, Daniel Plaksin, Tuvia Peretz, Boaz Amit, Lena Cooperman, Yocheved Hagay, Esther Szanton, Yariv Kanfi, Rachel Ben-Levy, Tali Szrajber
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Publication number: 20050069955Abstract: The present invention provides antibodies or fragments thereof that bind to cancer cells and is important in physiological phenomena, such as cell rolling and metastasis. Therapeutic and diagnostic methods and compositions using such antibody fragments thereof are also provided. The methods and compositions according to the present invention can be used in targeting therapeutic agents and in diagnosis, prognosis, and staging of and therapy for such diseases as cancer, including tumor growth and metastasis, leukemia, auto-immune disease, and inflammatory disease. Also provided is a library of immunoglobulin binding domains having a diverse antigen-binding domain for complementary binding, wherein the library has diversity only in heavy chain CDR3.Type: ApplicationFiled: June 30, 2004Publication date: March 31, 2005Inventors: Daniel Plaksin, Avigdor Levanon, Esther Szanton, Yocheved Hagay, Rachel Ben-Levy, Yael Nisgav, Yariv Kanfi